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pro vyhledávání: '"Alison K. Berger"'
Publikováno v:
Biological Psychiatry. 69:288-294
Background Prepulse inhibition (PPI) is a cross-species measure of sensorimotor gating. PPI deficits are observed in humans and rats upon acute treatment with dopamine D 2 -like receptor agonists and in patients with schizophrenia. Repeated treatment
Autosomal recessive loss-of-function mutations within the PARK2 gene functionally inactivate the E3 ubiquitin ligase parkin, resulting in neurodegeneration of catecholaminergic neurons and a familial form of Parkinson disease. Current evidence sugges
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf5119d5d80c93023c30a88eb2179e7
https://europepmc.org/articles/PMC3341078/
https://europepmc.org/articles/PMC3341078/
Autor:
Andreas Weihofen, Alison K. Berger, Giuseppe P. Cortese, Katherine D. Amodeo, Anthony Letai, Matthew J. LaVoie
Publikováno v:
Human molecular genetics. 18(22)
Autosomal-recessive mutations in the Parkin gene are the second most common cause of familial Parkinson's disease (PD). Parkin deficiency leads to the premature demise of the catecholaminergic neurons of the ventral midbrain in familial PD. Thus, a b