Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alison J. Weston"'
Autor:
Steven J. Moss, Vidya Math, Alison J. Weston, Carlos Olano, Barrie Wilkinson, Rose Mary Sheridan, Peter F. Leadlay, José A. Salas, Alfredo F. Braña, Carmen Méndez
Publikováno v:
Molecular Microbiology. 52:1745-1756
The 18-membered polyketide macrolide borrelidin exhibits a number of important biological activities, including potent angiogenesis inhibition. This has prompted two recent total syntheses as well as the cloning of the biosynthetic gene cluster from
Autor:
Markiyan Oliynyk, Carlos Olano, Rose Mary Sheridan, Peter F. Leadlay, Steven J. Moss, Cesar Sanchez, Carmen Méndez, Vidya Math, Alfredo F. Braña, José A. Salas, Barrie Wilkinson, Alison J. Weston, Christine Martin
Publikováno v:
Chemistry & Biology. 11(1):87-97
The biosynthetic gene cluster for the angiogenesis inhibitor borrelidin has been cloned from Streptomyces parvulus Tu4055. Sequence analysis indicates that the macrolide ring of borrelidin is formed by a modular polyketide synthase (PKS) (borA1-A6),
Autor:
Carlos, Olano, Steven J, Moss, Alfredo F, Braña, Rose M, Sheridan, Vidya, Math, Alison J, Weston, Carmen, Méndez, Peter F, Leadlay, Barrie, Wilkinson, José A, Salas
Publikováno v:
Molecular microbiology. 52(6)
The 18-membered polyketide macrolide borrelidin exhibits a number of important biological activities, including potent angiogenesis inhibition. This has prompted two recent total syntheses as well as the cloning of the biosynthetic gene cluster from
Autor:
Sabine Gaisser, Matthew Alan Gregory, James Staunton, Hui Hong, Rachel E. Lill, Alison J. Weston, Rose Mary Sheridan, Isabelle Carletti, Peter F. Leadlay, Barrie Wilkinson, Huai-Lo Lee, Hrvoje Petković
Publikováno v:
Angewandte Chemie (International ed. in English). 43(19)
Autor:
Carlos, Olano, Barrie, Wilkinson, César, Sánchez, Steven J, Moss, Rose, Sheridan, Vidya, Math, Alison J, Weston, Alfredo F, Braña, Christine J, Martin, Markiyan, Oliynyk, Carmen, Méndez, Peter F, Leadlay, José A, Salas
Publikováno v:
Chemistrybiology. 11(1)
The biosynthetic gene cluster for the angiogenesis inhibitor borrelidin has been cloned from Streptomyces parvulus Tü4055. Sequence analysis indicates that the macrolide ring of borrelidin is formed by a modular polyketide synthase (PKS) (borA1-A6),
Autor:
Barrie Wilkinson, Steven G. Kendrew, Lindsey Low, Rose Mary Sheridan, James Staunton, Rachel E. Lill, Peter F. Leadlay, Alison J. Weston, Ian S. Galloway, Gabriele Wirtz, Sabine Gaisser, Kim Jonelle Stutzman-Engwall, Hamish A. I. McArthur, Andrew L. Kaja, Laurenz Kellenberger
Publikováno v:
Organicbiomolecular chemistry. 1(16)
Ivermectin™, a mixture of 22,23-dihydroavermectin B1a 9 with minor amounts of 22,23-dihydroavermectin B1b 10, is one of the most successful veterinary antiparasitic drugs ever produced. In humans, ivermectin has been used for the treatment of Afric
Autor:
Sabine, Gaisser, Christine J, Martin, Barrie, Wilkinson, Rose M, Sheridan, Rachel E, Lill, Alison J, Weston, Sarah J, Ready, Clive, Waldron, Gary D, Crouse, Peter F, Leadlay, James, Staunton
Publikováno v:
Chemical communications (Cambridge, England). (6)
Novel spinosyns have been prepared by biotransformation, using a genetically engineered strain of Saccharopolyspora erythraea, in which the beta-D-forosamine moiety in glycosidic linkage to the hydroxy group at C17 is replaced by alpha-L-mycarose.
Autor:
Barrie Wilkinson, Hrvoje Petković, Iain R. Challis, Sarah J. Ready, Peter F. Leadlay, Isabelle Carletti, Michael Ward, Hui Hong, Alison J. Weston, Lindsey Low, Rose Mary Sheridan, Rachel E. Lill, Christine Martin, Sabine Gaisser, Matthew Alan Gregory, Andrew L. Kaja, Lesley S. Sheehan
Publikováno v:
Organic & Biomolecular Chemistry. 4:3565
The function of gene products involved in the biosynthesis of the clinically important polyketide rapamycin were elucidated by biotransformation and gene complementation.
Autor:
Matthew A. Gregory, Sabine Gaisser, Rachel E. Lill, Hui Hong, Rose M. Sheridan, Barrie Wilkinson, Hrvoje Petkovic, Alison J. Weston, Isabelle Carletti, Huai-Lo Lee, James Staunton, Peter F. Leadlay
Publikováno v:
Angewandte Chemie; May2003, Vol. 116 Issue 19, p2605-2607, 3p