Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alison J. Gillespie"'
Autor:
Jeffrey J. James, Alison J. Gillespie, Yuko Ogata, J. Alaina Floyd, Jeremy M. Shaver, Nancy S. Nightlinger, Richard S. Rogers, Unjy Park, Bruce A. Kerwin
Publikováno v:
Journal of Pharmaceutical Sciences
Formulation screening for biotherapeutics can cover a vast array of excipients and stress conditions. These studies consume quantities of limited material and, with higher concentrated therapeutics, more material is needed. Here, we evaluate the use
Autor:
Chelsey Bennett, Mcclure Megan J, Georgia D. Tomaras, Michael S. Seaman, Clark Rutilio H, Randal R. Ketchem, J. Alaina Floyd, Kelly E. Seaton, Christine C. Siska, Yan Brodsky, Jeremy M. Shaver, Bryan T. Mayer, Nicole L. Yates, Bruce A. Kerwin, Alison J. Gillespie
Publikováno v:
Journal of Pharmaceutical Sciences
The broadly neutralizing anti-HIV antibody, 10-1074, is a highly somatically hypermutated IgG1 being developed for prophylaxis in sub-Saharan Africa. A series of algorithms were applied to identify potentially destabilizing residues in the framework
Autor:
Dean Pettit, Kevin J. Whaley, Jane Ennis, Michael T. Trentalange, Richard S. Rogers, Danielle Pace, Alison J. Gillespie, Brittney Livingston, Edith Nalbandian, Chris Crowell, Kelly K. Arthur, Ron Gillespie, Michael H. Pauly, Yan Brodsky, Ken Timmons, James N Thomas, Larry Zeitlin, Smidt Pauline S, Clark Rutilio H
Publikováno v:
mAbs. 8:347-357
From March 2014 through February 2015, the Ebola virus spread rapidly in West Africa, resulting in almost 30,000 infections and approximately 10,000 deaths. With no approved therapeutic options available, an experimental antibody cocktail known as ZM
Publikováno v:
Journal of Chromatography A. 1409:60-69
This work examines the binding of 15 different VH3 IgGs and their corresponding F(ab')2 fragments to two different protein A chromatography resins: MabSelect(®), which utilizes a recombinant protein A ligand, and MabSelect SuRe(®) (SuRe), which uti
Autor:
Richard S. Rogers, Yuling Zhang, Alison J. Gillespie, Nancy S Nightlinger, Alain Balland, Robert Bailey
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 997
In this communication, a high-throughput method for automated data analysis of cysteine-related product quality attributes (PQAs) in IgG2 antibodies is reported. This method leverages recent advances in the relative quantification of PQAs to facilita