Salivary glands regenerate after radiation injury through SOX2‐mediated secretory cell replacement

Autor: Elaine Emmerson, Alison J May, Lionel Berthoin, Noel Cruz‐Pacheco, Sara Nathan, Aaron J Mattingly, Jolie L Chang, William R Ryan, Aaron D Tward, Sarah M Knox

Publikováno v: EMBO Molecular Medicine, Vol 10, Iss 3, Pp 1-18 (2018)

Abstract Salivary gland acinar cells are routinely destroyed during radiation treatment for head and neck cancer that results in a lifetime of hyposalivation and co‐morbidities. A potential regenerative strategy for replacing injured tissue is the

Externí odkaz: https://doaj.org/article/4176d4197b9e49dfbb2cac3c79cfc025

Functional Specialization of Human Salivary Glands and Origins of Proteins Intrinsic to Human Saliva

Autor: Marie Saitou, Eliza A. Gaylord, Erica Xu, Alison J. May, Lubov Neznanova, Sara Nathan, Anissa Grawe, Jolie Chang, William Ryan, Stefan Ruhl, Sarah M. Knox, Omer Gokcumen

Publikováno v: Cell Reports, Vol 33, Iss 7, Pp 108402- (2020)

Summary: Salivary proteins are essential for maintaining health in the oral cavity and proximal digestive tract, and they serve as potential diagnostic markers for monitoring human health and disease. However, their precise organ origins remain uncle

Externí odkaz: https://doaj.org/article/06a14fb0acde454e88472ef286d8730f

A mechanism of gene evolution generating mucin function

Autor: Petar Pajic, Shichen Shen, Jun Qu, Alison J. May, Sarah Knox, Stefan Ruhl, Omer Gokcumen

Publikováno v: Science advances, vol 8, iss 34

How novel gene functions evolve is a fundamental question in biology. Mucin proteins, a functionally but not evolutionarily defined group of proteins, allow the study of convergent evolution of gene function. By analyzing the genomic variation of muc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a8069a02b8033ec988c79fa617c977
https://doi.org/10.1126/sciadv.abm8757

Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling

Autor: Alison J. May, Aaron J. Mattingly, Eliza A. Gaylord, Nathan Griffin, Sonia Sudiwala, Noel Cruz-Pacheco, Elaine Emmerson, Seayar Mohabbat, Sara Nathan, Hanan Sinada, Isabelle M.A. Lombaert, Sarah M. Knox

Publikováno v: May, A J, Mattingly, A J, Gaylord, E A, Griffin, N, Sudiwala, S, Cruz-Pacheco, N, Emmerson, E, Mohabbat, S, Nathan, S, Sinada, H, Lombaert, I & Knox, S M 2022, ' Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling ', Developmental Cell, vol. 57, no. 22, pp. 2550-2565.e5 . https://doi.org/10.1016/j.devcel.2022.10.011

Acinar cells are the principal secretory units of multiple exocrine organs. A single-cell, layered, lumenized acinus forms from a large cohort of epithelial progenitors that must initiate and coordinate three cellular programs of acinar specification

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3218b114ab6b7307b65f96a6a14d4e60
https://pubmed.ncbi.nlm.nih.gov/36413949

FGF10 is an essential regulator of tracheal submucosal gland morphogenesis

Autor: Alison J May, Alistair Noble, Abigail S. Tucker, Tathyane Hn Teshima

Publikováno v: May, A J, Teshima, T HN, Noble, A & Tucker, A S 2019, ' FGF10 is an essential regulator of tracheal submucosal gland morphogenesis ', Developmental Biology, vol. 451, no. 2, pp. 158-166 . https://doi.org/10.1016/j.ydbio.2019.03.017

Mucus secretion and mucociliary clearance are crucial processes required to maintain pulmonary homeostasis. Inthe trachea and nasal passages, mucus is secreted by submucosal glands (SMGs) that line the airway, with anadditional contribution from gobl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f10aa1cb54f8f990d82a78a699723e
https://pubmed.ncbi.nlm.nih.gov/30965042