Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

Autor: Kiran Musunuru, Aldons J. Lusis, Juan Fernández-Tajes, Michelle Simon, Lydia Quaye, Peter Arner, Jordana T. Bell, Momoko Horikoshi, Avanthi Raghavan, Andrew P. Morris, Ana Viñuela, Xiao Wang, Nam Che, Ingrid Dahlman, Qiurong Ding, Mete Civelek, Matt J. Neville, Fredrik Karpe, Siddharth Sethi, Unnur Thorsteinsdottir, Calvin Pan, Kerrin S. Small, Gudmar Thorleifsson, Pei-Chien Tsai, Mark I. McCarthy, Markku Laakso, Marianne Yon, Alison Hugill, Anubha Mahajan, Anna L. Gloyn, Marijana Todorčević, Kari Stefansson, Roger D. Cox, Julia S. El-Sayed Moustafa, Alfonso Buil, Abhishek Nag, Craig A. Glastonbury

Publikováno v: Small, K S, Marijana, M, Civelek, M, El-Sayed Moustafa, J S, Wang, X, Simon, M M, Tajes, J F, Mahajan, A, Horikoshi, M, Hugill, A, Glastonbury, C A, Quaye, L, Neville, M J, Sethi, S, Yon, M, Pan, C, Che, N, Vinuela, A, Tsai, P-C, Nag, A, Buil, A, Thorleifsson, G, Raghavan, A, Ding, Q, Morris, A P, Bell, J T, Thorsteinsdottir, U, Stefansson, K, Laakso, M, Dahlman, I, Arner, P, Gloyn, A L, Musunuru, K, Lusis, A J, Cox, R D, Karpe, F & McCarthy, M I 2018, ' Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition ', Nature Genetics, vol. 50, pp. 572–580 . https://doi.org/10.1038/s41588-018-0088-x
Nature Genetics
Small, K S, Todorčević, M, Civelek, M, El-Sayed Moustafa, J S, Wang, X, Simon, M M, Fernandez-Tajes, J, Mahajan, A, Horikoshi, M, Hugill, A, Glastonbury, C A, Quaye, L, Neville, M J, Sethi, S, Yon, M, Pan, C, Che, N, Viñuela, A, Tsai, P-C, Nag, A, Buil, A, Thorleifsson, G, Raghavan, A, Ding, Q, Morris, A P, Bell, J T, Thorsteinsdottir, U, Stefansson, K, Laakso, M, Dahlman, I, Arner, P, Gloyn, A L, Musunuru, K, Lusis, A J, Cox, R D, Karpe, F & McCarthy, M I 2018, ' Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition ', Nature Genetics, vol. 50, no. 4, pp. 572-580 . https://doi.org/10.1038/s41588-018-0088-x

Individual risk of type 2 diabetes (T2D) is modified by perturbations of adipose mass, distribution and function. To investigate mechanisms responsible, we explored the molecular, cellular, and whole-body effects of T2D-associated alleles near KLF14.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2a48142a73254b78b7f405200b5b31
https://doi.org/10.1038/s41588-018-0088-x

Loss of arylformamidase with reduced thymidine kinase expression leads to impaired glucose tolerance

Autor: Fay Probert, Tertius Hough, Roger D. Cox, I. Jane Cox, Gary Wall, Marianne Yon, Alison Hugill, Cheryl L. Scudamore, Liz Bentley, Michelle Stewart, Sara Wells

Publikováno v: Biology Open, Vol 4, Iss 11, Pp 1367-1375 (2015)
Biology Open

Tryptophan metabolites have been linked in observational studies with type 2 diabetes, cognitive disorders, inflammation and immune system regulation. A rate-limiting enzyme in tryptophan conversion is arylformamidase (Afmid), and a double knockout o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231e22eacf9264305029e688ebee359f
http://bio.biologists.org/content/4/11/1367

RNA‐sequencing of WFS1‐deficient pancreatic islets

Autor: Sulev Kõks, Marilin Ivask, Alison Hugill

Publikováno v: Physiological Reports
Physiological reports

Wolfram syndrome, an autosomal recessive disorder characterized by juvenile‐onset diabetes mellitus and optic atrophy, is caused by mutations in the WFS1 gene. WFS1 encodes an endoplasmic reticulum resident transmembrane protein. The Wfs1‐null mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aec23061f9061d3d1c90fd2e0ab00953
http://europepmc.org/articles/PMC4831324

Politics by Other Means : Selected Criticism From Review 31

Autor: Houman Barekat, Alison Hugill

Launched in October 2011, the online literary journal Review 31 - www.review31.co.uk - enjoys a growing reputation as one of the most intelligent and thoughtful literary resources on the web. Publishing accessible and informed reviews of the most int

Deletion of Nicotinamide Nucleotide Transhydrogenase

Autor: Neil Dear, Alison Hugill, Frances M. Ashcroft, Roger D. Cox, Helen Freeman

Publikováno v: Diabetes. 55:2153-2156

The C57BL/6J mouse displays glucose intolerance and reduced insulin secretion. The genetic locus underlying this phenotype was mapped to nicotinamide nucleotide transhydrogenase (Nnt) on mouse chromosome 13, a nuclear-encoded mitochondrial protein in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0056156e20a744c22519d2939b8b0a09
https://doi.org/10.2337/db06-0358