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pro vyhledávání: '"Alison Geerdes"'
Publikováno v:
American Journal of Physiology-Renal Physiology. 264:F907-F916
Preceding ischemia or concurrent hypotension is known to enhance aminoglycoside nephrotoxicity; however, the underlying mechanisms responsible have not been determined. To investigate the effect of preceding mild ischemia on cellular gentamicin handl
Autor:
Christopher Meyer, Ruben M. Sandoval, Rolf Dahl, Bruce A. Molitoris, Alison Geerdes, David P. Sundin
Publikováno v:
The American journal of physiology. 272(4 Pt 1)
In the rat, nephrotoxicity results from uptake of gentamicin at the apical membrane of proximal tubule (PT) cells. However, during continuous gentamicin treatment, the PT epithelium has been shown to recover. The mechanism(s) of cellular recovery and