Výsledky vyhledávání - "Alison F. Chalker"

A genomic analysis of two-component signal transduction in Streptococcus pneumoniae

Autor: Kristin K. Koretke, Andrea Marra, Martin Rosenberg, David J. Holmes, Karen A. Ingraham, Martin Karl Russel Burnham, Nicola G. Wallis, John P. Throup, Yigong Ge, Alexander P. Bryant, Alison F. Chalker, James R. Brown

Publikováno v: Molecular Microbiology. 35:566-576

A genomics-based approach was used to identify the entire gene complement of putative two-component signal transduction systems (TCSTSs) in Streptococcus pneumoniae. A total of 14 open reading frames (ORFs) were identified as putative response regula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71142cedbebac125617ad247aa7f25a1
https://doi.org/10.1046/j.1365-2958.2000.01725.x

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Identification, Evolution, and Essentiality of the Mevalonate Pathway for Isopentenyl Diphosphate Biosynthesis in Gram-Positive Cocci

Autor: E. Imogen Wilding, Serban Iordanescu, Michael N. Gwynn, David J. Holmes, Karen A. Ingraham, Alison F. Chalker, James R. Brown, Chi Y. So, Martin Rosenberg, Alexander P. Bryant

Publikováno v: Journal of Bacteriology. 182:4319-4327

The mevalonate pathway and the glyceraldehyde 3-phosphate (GAP)–pyruvate pathway are alternative routes for the biosynthesis of the central isoprenoid precursor, isopentenyl diphosphate. Genomic analysis revealed that the staphylococci, streptococc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a25759c53263559af49a612c74074256
https://doi.org/10.1128/jb.182.15.4319-4327.2000

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The bacA gene, which determines bacitracin susceptibility in Streptococcus pneumoniae and Staphylococcus aureus, is also required for virulence The GenBank accession number for the sequence reported in this paper is AF228662

Autor: David J. Holmes, Nicola G. Wallis, Alexander P. Bryant, Karen A. Ingraham, John Broskey, Stewart C. Pearson, Alison F. Chalker, Joanna Bryant, R. Dwayne Lunsford

Publikováno v: Microbiology. 146:1547-1553

Homologues of Escherichia coli bacA, encoding extremely hydrophobic proteins, were identified in the genomes of Staphylococcus aureus and Streptococcus pneumoniae. Allelic replacement mutagenesis demonstrated that the gene is not essential for in vit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e0c8d587950bdffb6d3b1b9625212ca
https://doi.org/10.1099/00221287-146-7-1547

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Characterization of Streptococcus pneumoniae 5-enolpyruvylshikimate 3-phosphate synthase and its activation by univalent cations

Autor: Marie J. Mazzulla, Lily Zhang, Wu-Schyong Liu, Wensheng Du, David J. Payne, Alison F. Chalker, Howard Kallender, Nicola G. Wallis

Publikováno v: European Journal of Biochemistry. 267:222-227

The aroA gene (Escherichia coli nomenclature) encoding 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase from the gram-positive pathogen Streptococcus pneumoniae has been identified, cloned and overexpressed in E. coli, and the enzyme purified to ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::314936bcca85e9131c2656a909204bed
https://doi.org/10.1046/j.1432-1327.2000.00994.x

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The Staphylococcus aureus ileS gene, encoding isoleucyl-tRNA synthetase, is a member of the T-box family

Autor: Tina M. Henkin, Margaret T. Haldeman, Gillian M. Hornblow, Judith M. Ward, Frank J. Grundy, Alison F. Chalker

Publikováno v: Journal of Bacteriology. 179:3767-3772

The Staphylococcus aureus ileS gene, encoding isoleucyl-tRNA synthetase (IleRS), contains a long mRNA leader region. This region exhibits many of the features of the gram-positive synthetase gene family, including the T box and leader region terminat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80304b01484670ab6eb58cae661e783
https://doi.org/10.1128/jb.179.11.3767-3772.1997

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The effects of central asymmetry on the propagation of palindromic DNA in bacteriophage lambda are consistent with cruciform extrusion in vivo

Autor: David R. F. Leach, Angus Davison, Ewa A. Okely, Alison F. Chalker

Publikováno v: Scopus-Elsevier

The propagation of lambda phages carrying long perfect palindromes has been compared with that of phages carrying imperfect palindromes with small regions of central asymmetry. The perfect palindromes confer a more deleterious phenotype than those wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d8c8ab4de555bb8735ece2c3e81f7fa
https://doi.org/10.1093/genetics/133.2.143

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A global approach to identify novel broad-spectrum antibacterial targets among proteins of unknown function

Publikováno v: Journal of molecular microbiology and biotechnology. 6(2)

Attempted allelic replacement of 144 Streptococcus pneumoniae open reading frames of previously uncharacterized function led to the identification of 36 genes essential for growth under laboratory conditions. Of these, 14 genes (obg, spoIIIJ2, trmU,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::204cbc08cec079f27f6af9185a09ca9d
https://pubmed.ncbi.nlm.nih.gov/15044829

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Rational identification of new antibacterial drug targets that are essential for viability using a genomics-based approach

Autor: Alison F Chalker, R. Dwayne Lunsford

Publikováno v: Pharmacologytherapeutics. 95(1)

In the last two decades, the search for completely novel antibacterial agents has acquired a new sense of urgency due to the remarkable rise of antibiotic resistance among key bacterial pathogens. More recently, the advent of bacterial genomics has p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a34daeb1224f2b1f8c187c392b14d93b
https://pubmed.ncbi.nlm.nih.gov/12163125

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