Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Alison F Feder"'
Autor:
Iris Yousaf, William W Hannon, Ryan C Donohue, Christian K Pfaller, Kalpana Yadav, Ryan J Dikdan, Sanjay Tyagi, Declan C Schroeder, Wun-Ju Shieh, Paul A Rota, Alison F Feder, Roberto Cattaneo
Publikováno v:
PLoS Pathogens, Vol 19, Iss 12, p e1011817 (2023)
It is increasingly appreciated that pathogens can spread as infectious units constituted by multiple, genetically diverse genomes, also called collective infectious units or genome collectives. However, genetic characterization of the spatial dynamic
Externí odkaz:
https://doaj.org/article/45dc155a609f44e6a3b8340c1ffbda95
Publikováno v:
eLife, Vol 10 (2021)
Triple-drug therapies have transformed HIV from a fatal condition to a chronic one. These therapies should prevent HIV drug resistance evolution, because one or more drugs suppress any partially resistant viruses. In practice, such therapies drastica
Externí odkaz:
https://doaj.org/article/68ca2701fe2d4c6da909973361d1453d
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009050 (2021)
HIV can evolve remarkably quickly in response to antiretroviral therapies and the immune system. This evolution stymies treatment effectiveness and prevents the development of an HIV vaccine. Consequently, there has been a great interest in using pop
Externí odkaz:
https://doaj.org/article/c9ba7632934242ce8d89a292cbefba1e
Publikováno v:
PLoS Genetics, Vol 14, Iss 12, p e1007855 (2018)
[This corrects the article DOI: 10.1371/journal.pgen.1007420.].
Externí odkaz:
https://doaj.org/article/d9aa9e751943493d90e76581fd9ef90d
Publikováno v:
PLoS Genetics, Vol 14, Iss 6, p e1007420 (2018)
HIV has a high mutation rate, which contributes to its ability to evolve quickly. However, we know little about the fitness costs of individual HIV mutations in vivo, their distribution and the different factors shaping the viral fitness landscape. W
Externí odkaz:
https://doaj.org/article/7aff9f29ed0147fe985f882a1265aec8
Autor:
Alison F Feder, Christopher Kline, Patricia Polacino, Mackenzie Cottrell, Angela D M Kashuba, Brandon F Keele, Shiu-Lok Hu, Dmitri A Petrov, Pleuni S Pennings, Zandrea Ambrose
Publikováno v:
PLoS Pathogens, Vol 13, Iss 5, p e1006358 (2017)
The process by which drug-resistant HIV-1 arises and spreads spatially within an infected individual is poorly understood. Studies have found variable results relating how HIV-1 in the blood differs from virus sampled in tissues, offering conflicting
Externí odkaz:
https://doaj.org/article/de0d502e01e8481392fecc0520d5a69f
Autor:
Alison F Feder, Soo-Yon Rhee, Susan P Holmes, Robert W Shafer, Dmitri A Petrov, Pleuni S Pennings
Publikováno v:
eLife, Vol 6 (2017)
Externí odkaz:
https://doaj.org/article/bc7a43c9ce3b4e98993be938df7019d4
Autor:
Alison F Feder, Soo-Yon Rhee, Susan P Holmes, Robert W Shafer, Dmitri A Petrov, Pleuni S Pennings
Publikováno v:
eLife, Vol 5 (2016)
In the early days of HIV treatment, drug resistance occurred rapidly and predictably in all patients, but under modern treatments, resistance arises slowly, if at all. The probability of resistance should be controlled by the rate of generation of re
Externí odkaz:
https://doaj.org/article/5458245ada0f46a3b6e0a43f08a63d28
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48588 (2012)
High-throughput pooled resequencing offers significant potential for whole genome population sequencing. However, its main drawback is the loss of haplotype information. In order to regain some of this information, we present LDx, a computational too
Externí odkaz:
https://doaj.org/article/aba66f144fde4a108bede6ba43d11ac3
Autor:
Kirk E Lohmueller, Anders Albrechtsen, Yingrui Li, Su Yeon Kim, Thorfinn Korneliussen, Nicolas Vinckenbosch, Geng Tian, Emilia Huerta-Sanchez, Alison F Feder, Niels Grarup, Torben Jørgensen, Tao Jiang, Daniel R Witte, Annelli Sandbæk, Ines Hellmann, Torsten Lauritzen, Torben Hansen, Oluf Pedersen, Jun Wang, Rasmus Nielsen
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002326 (2011)
A major question in evolutionary biology is how natural selection has shaped patterns of genetic variation across the human genome. Previous work has documented a reduction in genetic diversity in regions of the genome with low recombination rates. H
Externí odkaz:
https://doaj.org/article/56808897fcc548ae9546e571d9bbcc4b