Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Alison F Brading"'
Publikováno v:
Canadian Journal of Gastroenterology, Vol 16, Iss 4, Pp 249-257 (2002)
Recent research into the physiology and pharmacology of the internal anal sphincter has elucidated the importance of this structure in health and disease. Its pharmacological manipulation for therapeutic gain has focused mainly on agents to reduce in
Externí odkaz:
https://doaj.org/article/b6edd9639a1e42b7ae3138c040c14fe9
Publikováno v:
Diseases of the Colon & Rectum. 57:370-377
Background Interstitial cells of Cajal, expressing the proto-oncogene c-kit, have been shown to regulate the spontaneous activity of the gastrointestinal tract. They have been described in the human internal anal sphincter; however, their function is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2fedc1b44ee263fb7766b2f1bfb69f
https://doi.org/10.1097/01.dcr.0000442896.47732.e8
https://doi.org/10.1097/01.dcr.0000442896.47732.e8
Publikováno v:
Diseases of the Colon & Rectum. 55:465-472
Background Neoadjuvant chemoradiotherapy is recommended in the treatment of locally advanced rectal cancer. Studies have suggested that chemoradiotherapy adversely affects anorectal function. However, the functional implication and the underlying neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d147d1499beae1168a59bf0eea35a368
https://doi.org/10.1097/dcr.0b013e31824154a0
https://doi.org/10.1097/dcr.0b013e31824154a0
Publikováno v:
Neurourology and Urodynamics. 31:572-578
Aims We investigated the roles of neuronal-derived nitric oxide (NO) in the modulation of spontaneous activity of mouse detrusor smooth muscle. Methods Detrusor smooth muscle strips were isolated from nNOS gene knock-out (nNOS ) mice and their wild t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d615c5167c88a023552af3f3ff1ac0
https://doi.org/10.1002/nau.21247
https://doi.org/10.1002/nau.21247
Autor:
Margarida Ruas, Alison F. Brading, John Parrington, Kai-Ting Chuang, Antony Galione, Nezahat Tugba Durlu-Kandilci
Publikováno v:
The Journal of Biological Chemistry
Agonists such as those acting at muscarinic receptors are thought to induce contraction of smooth muscle primarily through inositol 1,4,5-trisphosphate production and release of Ca(2+) from sarcoplasmic reticulum. However, the additional Ca(2+)-mobil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0638adb490146bf1599b9d2130b6ba7
https://doi.org/10.1074/jbc.m110.129833
https://doi.org/10.1074/jbc.m110.129833
Publikováno v:
Neurourology and Urodynamics. 29:1326-1331
Aims Smooth muscles from the urethra and internal anal sphincter (IAS) play an essential role in the maintenance of urinary and fecal continence. Any damage in these muscles may cause serious problems. The aim of this study was to directly compare th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2598551a52d28c909037e52a51660e37
https://doi.org/10.1002/nau.20863
https://doi.org/10.1002/nau.20863
Publikováno v:
British Journal of Pharmacology. 152:1228-1238
Background and purpose: We have investigated the mechanisms underlying the paradoxical ability of the antispasmodic, alverine, to enhance spontaneous activity in smooth muscles while suppressing evoked activity. Experimental approach: The effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abe6e90393aef006c1aed958db5590d5
https://doi.org/10.1038/sj.bjp.0707496
https://doi.org/10.1038/sj.bjp.0707496
Autor:
Alison F. Brading, Bikram P. Choudhary, Charalambos Antoniades, David P. Taggart, Keith M. Channon, Antony Galione
Publikováno v:
Journal of the American College of Cardiology. 50(11):1047-1053
OBJECTIVES: Our purpose was to examine the impact of diabetes mellitus (DM) on vasoreactivity and endothelial function of radial artery (RA) grafts ex vivo. BACKGROUND: The arteriopathy associated with DM may influence the surgeon's choice of conduit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063c35bf25fd74aa40bca257257272c7
Publikováno v:
European Journal of Pharmacology. 566:172-180
Intracellular Ca2+ stores in rat and guinea-pig bladders and taenia caecum were studied in beta-escin skinned smooth muscle strips. 30 min of skinning with 40 microM and 80 microM beta-escin were the best parameters found to obtain good calcium respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffcda023fb0ba6a2fd16098ade5c448
https://doi.org/10.1016/j.ejphar.2007.03.041
https://doi.org/10.1016/j.ejphar.2007.03.041
Publikováno v:
Neurourology and Urodynamics. 27:79-87
Aims: To characterize the detrusor muscle of the mouse urinary bladder in order to understand more precisely spontaneous contractile behavior of this organ. This study examined the spontaneous electrical activity and Ca 2þ dynamics of the detrusor s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f55add6b54754a8bdfe92bacfaca78e
https://doi.org/10.1002/nau.20456
https://doi.org/10.1002/nau.20456