Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Alison F Brading"'
Autor:
Anant B. Parekh
Publikováno v:
The Journal of Physiology. 589:1871-1872
Alison Frances Brading, physiologist and pharmacologist: born Bexhill-on-Sea 26 February 1939; University Lecturer in Pharmacology, Oxford 1972–1995; Professor of Pharmacology, University of Oxford; Fellow of Lady Margaret Hall Oxford 1972–2005 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7547425c1bd8695c4b5a2b8a09b6b457
https://doi.org/10.1113/jphysiol.2011.207589
https://doi.org/10.1113/jphysiol.2011.207589
Akademický článek
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Publikováno v:
Canadian Journal of Gastroenterology, Vol 16, Iss 4, Pp 249-257 (2002)
Recent research into the physiology and pharmacology of the internal anal sphincter has elucidated the importance of this structure in health and disease. Its pharmacological manipulation for therapeutic gain has focused mainly on agents to reduce in
Externí odkaz:
https://doaj.org/article/b6edd9639a1e42b7ae3138c040c14fe9
Publikováno v:
Diseases of the Colon & Rectum. 57:370-377
Background Interstitial cells of Cajal, expressing the proto-oncogene c-kit, have been shown to regulate the spontaneous activity of the gastrointestinal tract. They have been described in the human internal anal sphincter; however, their function is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2fedc1b44ee263fb7766b2f1bfb69f
https://doi.org/10.1097/01.dcr.0000442896.47732.e8
https://doi.org/10.1097/01.dcr.0000442896.47732.e8
Publikováno v:
Diseases of the Colon & Rectum. 55:465-472
Background Neoadjuvant chemoradiotherapy is recommended in the treatment of locally advanced rectal cancer. Studies have suggested that chemoradiotherapy adversely affects anorectal function. However, the functional implication and the underlying neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d147d1499beae1168a59bf0eea35a368
https://doi.org/10.1097/dcr.0b013e31824154a0
https://doi.org/10.1097/dcr.0b013e31824154a0
Publikováno v:
Neurourology and Urodynamics. 31:572-578
Aims We investigated the roles of neuronal-derived nitric oxide (NO) in the modulation of spontaneous activity of mouse detrusor smooth muscle. Methods Detrusor smooth muscle strips were isolated from nNOS gene knock-out (nNOS ) mice and their wild t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4d615c5167c88a023552af3f3ff1ac0
https://doi.org/10.1002/nau.21247
https://doi.org/10.1002/nau.21247
Autor:
Margarida Ruas, Alison F. Brading, John Parrington, Kai-Ting Chuang, Antony Galione, Nezahat Tugba Durlu-Kandilci
Publikováno v:
The Journal of Biological Chemistry
Agonists such as those acting at muscarinic receptors are thought to induce contraction of smooth muscle primarily through inositol 1,4,5-trisphosphate production and release of Ca(2+) from sarcoplasmic reticulum. However, the additional Ca(2+)-mobil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0638adb490146bf1599b9d2130b6ba7
https://doi.org/10.1074/jbc.m110.129833
https://doi.org/10.1074/jbc.m110.129833
Publikováno v:
Neurourology and Urodynamics. 29:1326-1331
Aims Smooth muscles from the urethra and internal anal sphincter (IAS) play an essential role in the maintenance of urinary and fecal continence. Any damage in these muscles may cause serious problems. The aim of this study was to directly compare th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2598551a52d28c909037e52a51660e37
https://doi.org/10.1002/nau.20863
https://doi.org/10.1002/nau.20863
Publikováno v:
British Journal of Pharmacology. 152:1228-1238
Background and purpose: We have investigated the mechanisms underlying the paradoxical ability of the antispasmodic, alverine, to enhance spontaneous activity in smooth muscles while suppressing evoked activity. Experimental approach: The effects of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::abe6e90393aef006c1aed958db5590d5
https://doi.org/10.1038/sj.bjp.0707496
https://doi.org/10.1038/sj.bjp.0707496
Autor:
Alison F. Brading, Bikram P. Choudhary, Charalambos Antoniades, David P. Taggart, Keith M. Channon, Antony Galione
Publikováno v:
Journal of the American College of Cardiology. 50(11):1047-1053
OBJECTIVES: Our purpose was to examine the impact of diabetes mellitus (DM) on vasoreactivity and endothelial function of radial artery (RA) grafts ex vivo. BACKGROUND: The arteriopathy associated with DM may influence the surgeon's choice of conduit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063c35bf25fd74aa40bca257257272c7