Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alison E. Twelvetrees"'
Publikováno v:
F1000Research, Vol 6 (2017)
Axonal transport is the active process whereby neurons transport cargoes such as organelles and proteins anterogradely from the cell body to the axon terminal and retrogradely in the opposite direction. Bi-directional transport in axons is absolutely
Externí odkaz:
https://doaj.org/article/67906cf1793f4b709f21dca5e2d12a01
The Kinesin-1 family contains the founding members of the kinesin superfamily. Members of this family are general purpose motor proteins for movement towards the plus end of microtubules. The motor domains consist of a core domain of approximately 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2746b0a52373f24d6149a2a76c240f4
https://doi.org/10.1201/9780429491559-2
https://doi.org/10.1201/9780429491559-2
Autor:
Alison E. Twelvetrees
Publikováno v:
Seminars in celldevelopmental biology. 107
Neurons are incredibly reliant on their cytoskeletal transport machinery. During development the cytoskeleton is the primary driver of growth and remodelling. In mature neurons the cytoskeleton keeps all components in a constant state of movement, al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae0f0403cc571560b9caae2fdf69a6bc
https://pubmed.ncbi.nlm.nih.gov/32173271
https://pubmed.ncbi.nlm.nih.gov/32173271
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
The challenges facing a new independent group leader, principal investigator (PI) or university lecturer are formidable: secure funding, recruit staff and students, establish a research programme, give lectures, and carry out various administrative d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb79c834fee03db732528852107bed23
https://elifesciences.org/articles/46827
https://elifesciences.org/articles/46827
Publikováno v:
bioRxiv
BioRxiv
BioRxiv
The data in this report summarises the responses gathered from 365 principal investigators of academic laboratories, who started their independent positions in the UK within the last 6 years up to 2018. We find that too many new investigators express
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09339b37fa1b3cb574eb9edd5b13c3ec
Publikováno v:
Journal of Cell Science
Binding of motor proteins to cellular cargoes is regulated by adaptor proteins. HAP1 and GRIP1 are kinesin-1 adaptors that have been implicated individually in the transport of vesicular cargoes in the dendrites of neurons. We find that HAP1a and GRI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d37b810d1d2f8813c3f05865b089b2d
https://doi.org/10.1242/jcs.215822
https://doi.org/10.1242/jcs.215822
Autor:
Sebastian Amigorena, Michael S. Marks, Adriana R. Mantegazza, Allison L. Zajac, Alison E. Twelvetrees, Erika L.F. Holzbaur
Publikováno v:
Proceedings of the National Academy of Sciences. 111:15508-15513
Dendritic cells (DCs) phagocytose large particles like bacteria at sites of infection and progressively degrade them within maturing phagosomes. Phagosomes in DCs are also signaling platforms for pattern recognition receptors, such as Toll-like recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60c17ba3e3997a2789481cbbd8cd1ce
https://doi.org/10.1073/pnas.1412998111
https://doi.org/10.1073/pnas.1412998111
Autor:
Kiev R. Blasier, Jun Zhang, Jacob E. Lazarus, Alison E. Twelvetrees, Xin Xiang, Xuanli Yao, Nirja A. Inamdar, Erika L.F. Holzbaur, K. Kevin Pfister
Publikováno v:
Cytoskeleton. 70:215-227
Cytoplasmic dynein plays important roles in mitosis and the intracellular transport of organelles, proteins, and mRNAs. Dynein function is particularly critical for survival of neurons, as mutations in dynein are linked to neurodegenerative diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fa3e192bfca02faa77901b8f41bb006
https://doi.org/10.1002/cm.21102
https://doi.org/10.1002/cm.21102
Autor:
Xiao-Jiang Li, Eunice Y. Yuen, Ping Zhong, Shihua Li, Jing Wei, Alison E. Twelvetrees, Wenhua Liu, Lara J. Duffney, Jia Cheng, Madhuchhanda Mandal, Josef T. Kittler, Zhen Yan
Publikováno v:
Journal of Biological Chemistry. 286:33719-33728
Emerging evidence from studies of Huntington disease (HD) pathophysiology suggests that huntingtin (htt) and its associated protein HAP1 participate in intracellular trafficking and synaptic function. However, it is largely unknown whether AMPA recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1ccff33ff5048933d845c4186b7dde
https://doi.org/10.1074/jbc.m111.236521
https://doi.org/10.1074/jbc.m111.236521