Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Alison E. Fox-Robichaud"'
Autor:
Neha Sharma, Alex Chen, Leah Heinen, Ruth Liu, Dhruva J. Dwivedi, Ji Zhou, Manoj M. Lalu, Asher A. Mendelson, Braedon McDonald, Colin A. Kretz, Alison E. Fox-Robichaud, Patricia C. Liaw
Publikováno v:
Intensive Care Medicine Experimental, Vol 12, Iss 1, Pp 1-13 (2024)
Abstract Introduction Despite older adults being more vulnerable to sepsis, most preclinical research on sepsis has been conducted using young animals. This results in decreased scientific validity since age is an independent predictor of poor outcom
Externí odkaz:
https://doaj.org/article/27fd2b1cf7f24f92a98ec9a101867c38
Autor:
Shannon M. Fernando, MD, Alexandre Tran, MD, Karim Soliman, MD, Barbara Flynn, BScRN, Thomas Oommen, PharmD, Li Wenzhe, MD, Neill K.J. Adhikari, MDCM, Salmaan Kanji, PharmD, Andrew J.E. Seely, MD, PhD, Alison E. Fox-Robichaud, MD, Randy S. Wax, MD, FCCM, Deborah J. Cook, MD, François Lamontagne, MD, Bram Rochwerg, MD, FCCM
Publikováno v:
Critical Care Explorations, Vol 6, Iss 7, p e1110 (2024)
OBJECTIVES:. Although clinicians may use methylene blue (MB) in refractory septic shock, the effect of MB on patient-important outcomes remains uncertain. We conducted a systematic review and meta-analysis to investigate the benefits and harms of MB
Externí odkaz:
https://doaj.org/article/ae52b02a10dd4d4f8d7e87e5cd01a8f6
Autor:
Neha Sharma, Damian Chwastek, Dhruva J. Dwivedi, Jared Schlechte, Ian-Ling Yu, Braedon McDonald, Jaskirat Arora, Erblin Cani, Mikaela Eng, Doreen Engelberts, Eva Kuhar, Sarah K. Medeiros, Stephane L. Bourque, Gediminas Cepinskas, Sean E. Gill, Forough Jahandideh, Kimberly F. Macala, Sareh Panahi, Cynthia Pape, David Sontag, Janet Sunohara-Neilson, Dean A. Fergusson, Alison E. Fox-Robichaud, Patricia C. Liaw, Manoj M. Lalu, Asher A. Mendelson, for the National Preclinical Sepsis Platform, Sepsis Canada
Publikováno v:
Intensive Care Medicine Experimental, Vol 11, Iss 1, Pp 1-17 (2023)
Abstract Background Preclinical sepsis models have been criticized for their inability to recapitulate human sepsis and suffer from methodological shortcomings that limit external validity and reproducibility. The National Preclinical Sepsis Platform
Externí odkaz:
https://doaj.org/article/2a7fa924fb5b4658b0da38387de75a6e
Publikováno v:
Canadian Journal of Bioethics, Vol 6, Iss 1 (2023)
The COVID-19 pandemic has had a global effect. The disproportionate impact on Indigenous peoples and racialized groups has brought ethical challenges to the forefront in research and clinical practice. In Canada, the Tri-Council Policy Statement (TCP
Externí odkaz:
https://doaj.org/article/9aaa03c4d4f941a0bdbc27744d096c26
Publikováno v:
Critical Care, Vol 26, Iss 1, Pp 1-12 (2022)
Abstract Background Sepsis, the dysregulated host response to infection, triggers abnormal pro-coagulant and pro-inflammatory host responses. Limitations in early disease intervention highlight the need for effective diagnostic and prognostic biomark
Externí odkaz:
https://doaj.org/article/470ea39e251247e2a798faec1b95ceda
Autor:
Fatima Sheikh, BSc, William Douglas, BHSc, Vanessa Catenacci, BSc, Christina Machon, BHSc, Alison E. Fox-Robichaud, MSc, MD, FRCPC
Publikováno v:
Critical Care Explorations, Vol 4, Iss 7, p e0731 (2022)
OBJECTIVE:. Evaluating risk for sepsis is complicated due to limited understanding of how social determinants of health (SDoH) influence the occurence of the disease. This scoping review aims to identify gaps and summarize the existing literature on
Externí odkaz:
https://doaj.org/article/5a1c5f25e25748a08d75ca5c829d8085
Autor:
Asher A. Mendelson, Casey Lansdell, Alison E. Fox-Robichaud, Patricia Liaw, Jaskirat Arora, Jean-François Cailhier, Gediminas Cepinskas, Emmanuel Charbonney, Claudia dos Santos, Dhruva Dwivedi, Christopher G. Ellis, Dean Fergusson, Kirsten Fiest, Sean E. Gill, Kathryn Hendrick, Victoria T. Hunniford, Paulina M. Kowalewska, Karla Krewulak, Christian Lehmann, Kimberly Macala, John C. Marshall, Laura Mawdsley, Braedon McDonald, Ellen McDonald, Sarah K. Medeiros, Valdirene S. Muniz, Marcin Osuchowski, Justin Presseau, Neha Sharma, Sahar Sohrabipour, Janet Sunohara-Neilson, Gloria Vázquez-Grande, Ruud A. W. Veldhuizen, Donald Welsh, Brent W. Winston, Ryan Zarychanski, Haibo Zhang, Juan Zhou, Manoj M. Lalu, Sepsis Canada’s National Preclinical Sepsis Platform
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-19 (2021)
Abstract Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of translation include poor representation by precl
Externí odkaz:
https://doaj.org/article/9aeed005c2d54e4888a280f7bf96c4a3
Publikováno v:
Pilot and Feasibility Studies, Vol 6, Iss 1, Pp 1-10 (2020)
Abstract Background Critically ill patients in the intensive care unit (ICU) are at risk for central line-associated bloodstream infection (CLABSI) with an incidence up to 6.9 per 1000 catheter days. CLABSI has a significant attributable mortality an
Externí odkaz:
https://doaj.org/article/150d2f2543f04e138337dc4ccb7f61b5
Autor:
Nicholas L. Jackson Chornenki, Robert Coke, Andrew C. Kwong, Dhruva J. Dwivedi, Michael K. Xu, Ellen McDonald, John C. Marshall, Alison E. Fox-Robichaud, Emmanuel Charbonney, Patricia C. Liaw
Publikováno v:
Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-10 (2019)
Abstract Background Circulating cell-free DNA (cfDNA) may contribute to the pathophysiology of post-injury inflammation and coagulation in trauma. However, the source and mechanism of release of cfDNA in trauma is not well understood. One potential s
Externí odkaz:
https://doaj.org/article/4ea7ab47ada3402ea7852e9c3d0b0cde
Autor:
Shannon M. Fernando, Alison E. Fox-Robichaud, Bram Rochwerg, Pierre Cardinal, Andrew J. E. Seely, Jeffrey J. Perry, Daniel I. McIsaac, Alexandre Tran, Steven Skitch, Benjamin Tam, Michael Hickey, Peter M. Reardon, Peter Tanuseputro, Kwadwo Kyeremanteng
Publikováno v:
Critical Care, Vol 23, Iss 1, Pp 1-8 (2019)
Abstract Background Rapid response teams (RRTs) respond to hospitalized patients experiencing clinical deterioration and help determine subsequent management and disposition. We sought to evaluate and compare the prognostic accuracy of the Hamilton E
Externí odkaz:
https://doaj.org/article/e00e52ac91ba4e319e4fa25b4bc1e7ed