Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Alison E. Casey"'
Autor:
Yu-Jia Shiah, Pirashaanthy Tharmapalan, Alison E. Casey, Purna A. Joshi, Trevor D. McKee, Hartland W. Jackson, Alexander G. Beristain, Michelle A. Chan-Seng-Yue, Gary D. Bader, John P. Lydon, Paul D. Waterhouse, Paul C. Boutros, Rama Khokha
Publikováno v:
Stem Cell Reports, Vol 4, Iss 3, Pp 313-322 (2015)
Progesterone drives mammary stem and progenitor cell dynamics through paracrine mechanisms that are currently not well understood. Here, we demonstrate that CXCR4, the receptor for stromal-derived factor 1 (SDF-1; CXC12), is a crucial instructor of h
Externí odkaz:
https://doaj.org/article/7ef44eb58c7349ed8180897fb814a2db
Autor:
Ankit Sinha, Hyeyeon Kim, Jennifer Cruickshank, Mina Alam, Marianne Koritzinsky, Mar Garcia-Valero, Curtis W McCloskey, Rama Khokha, Ravi N. Vellanki, Mathepan Mahendralingam, Luis Palomero, Vid Stambolic, Alison E. Casey, Ronak Shetty, Aaron D. Schimmer, Pirashaanthy Tharmapalan, Miquel Angel Pujana, Davide Pellacani, Vladimir Ignatchenko, Connie J. Eaves, Thomas Kislinger, Kazeera Aliar, Hal K. Berman
Publikováno v:
Nature Metabolism. 3:665-681
Cancer metabolism adapts the metabolic network of its tissue of origin. However, breast cancer is not a disease of a single origin. Multiple epithelial populations serve as the culprit cell of origin for specific breast cancer subtypes, yet our knowl
Autor:
Miquel Angel Pujana, Michael J. Parsons, Hal K. Berman, Alison E. Casey, Luis Palomero, Kazeera Aliar, Thomas Kislinger, Swami R. Narala, Hyun-Chul Kim, Paul Waterhouse, Hofer S, Rama Khokha, Francesca Mateo, Mathepan Mahendralingam
It has long been assumed that all normal cells have the same capacity to engage homologous recombination (HR) and non-homologous end joining (NHEJ) to repair DNA double-strand breaks (DSBs), a concept exploited for DNA-damaging chemotherapeutics. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b8196882f05813d0581edeca35c6e37
https://doi.org/10.1101/2021.05.14.444217
https://doi.org/10.1101/2021.05.14.444217
Autor:
Hal K. Berman, Thomas Kislinger, Mathepan Mahendralingam, Kazeera Aliar, Vid Stambolic, Rama Khokha, Mar Garcia Valero, Miquel Angel Pujana, Aaron D. Schimmer, Connie J. Eaves, Alison E. Casey, Mina Alam, Davide Pellacani, Luis Palomero, Ankit Sinha, Hyeyeon Kim, Vladimir Ignatchenko
Cancer metabolism adapts the metabolic network of its tissue-of-origin. However, breast cancer is not a disease of a singular origin. Multiple epithelial populations serve as the culprit cell-of-origin for specific breast cancer subtypes, yet knowled
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5561e93cc995df4d47f2f435cc109833
Autor:
Dalia Barsyte-Lovejoy, Julie Livingstone, Ruth Isserlin, Geneviève Deblois, Hui Fang, Daniel D. De Carvalho, Tiago Medina, Thomas Kislinger, Paul C. Boutros, Pirashaanthy Tharmapalan, Alison E. Casey, Stefan Hofer, Swneke D. Bailey, Erik Drysdale, Hal K. Berman, Gary D. Bader, Mona Shehata, Rama Khokha, Mathieu Lupien, Yu-Jia Shiah, Rajat Singhania, Cheryl H. Arrowsmith, Stefan Knapp, Paul Waterhouse, Ankit Sinha, Hyeyeon Kim, Jennifer Cruickshank
Publikováno v:
The Journal of cell biology, vol 217, iss 8
The Journal of Cell Biology
The Journal of Cell Biology
Casey et al. integrate epigenomic, transcriptomic, and proteomic profiling of primary basal and luminal mammary cells to identify master epigenetic regulators of the mammary epithelium and uncover stem and progenitor cell vulnerabilities. They develo
Autor:
Mathepan Mahendralingam, Marianne Koritzinsky, Paul Waterhouse, Rama Khokha, Ravi N. Vellanki, Mona Shehata, Hyeyeon Kim, Alison E. Casey
Publikováno v:
Communications Biology
Communications Biology, Vol 2, Iss 1, Pp 1-11 (2019)
Communications Biology, Vol 2, Iss 1, Pp 1-11 (2019)
The heterogeneity of breast cancer makes current therapies challenging. Metformin, the anti-diabetic drug, has shown promising anti-cancer activities in epidemiological studies and breast cancer models. Yet, how metformin alters the normal adult brea
Publikováno v:
Communications Biology, Vol 1, Iss 1, Pp 1-10 (2018)
Breast cancer is the most common cancer in females. The number of years menstruating and length of an individual menstrual cycle have been implicated in increased breast cancer risk. At present, the proliferative changes within an individual reproduc
Autor:
Rama Khokha, John P. Lydon, Trevor D. McKee, Yu Jia Shiah, Pirashaanthy Tharmapalan, Purna A. Joshi, Paul Waterhouse, Michelle Chan-Seng-Yue, Paul C. Boutros, Hartland W. Jackson, Alison E. Casey, Alexander G. Beristain, Gary D. Bader
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 4, Iss 3, p 529 (2015)
Stem Cell Reports, Vol 4, Iss 3, Pp 313-322 (2015)
Stem cell reports, vol 4, iss 3
Stem Cell Reports, Vol 4, Iss 3, p 529 (2015)
Stem Cell Reports, Vol 4, Iss 3, Pp 313-322 (2015)
Stem cell reports, vol 4, iss 3
Summary Progesterone drives mammary stem and progenitor cell dynamics through paracrine mechanisms that are currently not well understood. Here, we demonstrate that CXCR4, the receptor for stromal-derived factor 1 (SDF-1; CXC12), is a crucial instruc