Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alison E. Bretnall"'
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 96
Spray Dried Dispersions (SDD) are uniform mixtures of a specific ratio of amorphous active pharmaceutical ingredient (API) and polymer prepared via a spray drying process. Volatile solvents are employed during spray drying to facilitate the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec23cbac1b89368e20e65254d9d93d1
https://pubmed.ncbi.nlm.nih.gov/24721204
https://pubmed.ncbi.nlm.nih.gov/24721204
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 92
This work describes the development and validation of an analytical method to determine residual trace levels of 2-Hydroxypyridine-1-Oxide (HOPO) in an active pharmaceutical ingredient (API). A method was required to be specific and sensitive enough
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f58a8498ca0710dc34c57cf6e6a9c0af
https://pubmed.ncbi.nlm.nih.gov/24525561
https://pubmed.ncbi.nlm.nih.gov/24525561
Publikováno v:
British Journal of Haematology. 95:654-659
A hamster model has been developed for studying desferrioxamine. The hamster shows many similarities to man in terms of plasma stability and metabolites formed from desferrioxamine. The [59Fe]ferritin derived from rats has been shown to be sequestere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea34834bb3efc69a7c2c679bf5bbfe9
https://doi.org/10.1046/j.1365-2141.1996.d01-1956.x
https://doi.org/10.1046/j.1365-2141.1996.d01-1956.x
Autor:
Graham S. Clarke, Alison E. Bretnall
Publikováno v:
Journal of Chromatography A. 745:145-154
Examples of several classes of cardiovascular drugs have been separated using capillary electrophoresis and its associated application, micellar electrokinetic chromatography. The therapeutic classes of drug investigated include β-blockers, antiarrh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e8f2190c5e5aa5a3f95159aac1c0ec8
https://doi.org/10.1016/0021-9673(96)00243-9
https://doi.org/10.1016/0021-9673(96)00243-9
Autor:
Graham S. Clarke, Alison E. Bretnall
Publikováno v:
Journal of Chromatography A. 716:49-55
The effect of organic modifiers (methanol, ethanol, propan-2-ol, butan-1-ol, butan-2-ol, acetone, methyl ethyl ketone and acetonitrile) on the micellar electrokinetic chromatographic (MEKC) resolution and migration time of seven model compounds has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17eef8411879ed0ad62d6550d2bcd9fa
https://doi.org/10.1016/0021-9673(95)00374-v
https://doi.org/10.1016/0021-9673(95)00374-v
Autor:
Alison E. Bretnall, Graham S. Clarke
The generation of high-quality analytical data is imperative in the effective knowledge generation and development of new medicines. Analytical methods are the tools that generate data are used to make fundamental development decisions, and validatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c6f1e1f6314ef7283d8a0e6a985b314
https://doi.org/10.1016/b978-0-12-375680-0.00011-5
https://doi.org/10.1016/b978-0-12-375680-0.00011-5
Autor:
H. Abdel-Aleem, Lisa Aditama, Omar A. Al Deeb, Eugene S. Barabas, F. Belal, Alison E. Bretnall, Harry G. Brittain, Marvin A. Brooks, Zui Lin Chang, Graham S. Clarke, Alekha K. Dash, A.A. El-Amam, M.B. El-Ashmawy, Hussein I. El-Subbagh, Klaus Florey, Nagwa H. Foda, Lee T. Grady, Gunawan Indrayanto, Dominic P. Ip, Tjiang Lianawati, George S. Mahler, David J. Mazzo, Michael J. McLeish, null Moegihardjo, Claudia C. Okeke, Mahasen A. Radwan, Christopher T. Riley, Amal Shervington, Leroy A. Shervington, null Soeharyono, V. Srini Srinivasan, Achmad Syahrani, Iis Wahyuningsih, Timothy J. Wozniak
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec0f588fc93950e28448e190d2f5e968
https://doi.org/10.1016/s0099-5428(08)60749-2
https://doi.org/10.1016/s0099-5428(08)60749-2
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 15(8)
This study describes a specific, linear, precise, accurate and sensitive method for the determination of a developmental cholesterol-lowering drug formulated in capsules. The method can also determine two known hydrolytic degradants of the drug. Samp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1bc1e2a1f5f154718e9989faf17190
https://pubmed.ncbi.nlm.nih.gov/9215959
https://pubmed.ncbi.nlm.nih.gov/9215959
Autor:
Graham S. Clarke, Alison E. Bretnall
Publikováno v:
Journal of chromatography. A. 700(1-2)
A micellar electrokinetic chromatography method was optimised for the separation of the six cardiovascular drugs atenolol, nicardipine, nifedipine, diltiazem, verapamil, and amlodipine by investigating the effects of pH, sodium dodecyl sulphate (SDS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::273b4e92ed363ee012e026e840dcfd90
https://pubmed.ncbi.nlm.nih.gov/7767462
https://pubmed.ncbi.nlm.nih.gov/7767462