Výsledky vyhledávání - "Alison Dumont"

Akademický článek

ChemR23 activation reprograms macrophages toward a less inflammatory phenotype and dampens carcinoma progression

Autor: Margot Lavy, Vanessa Gauttier, Alison Dumont, Florian Chocteau, Sophie Deshayes, Judith Fresquet, Virginie Dehame, Isabelle Girault, Charlène Trilleaud, Stéphanie Neyton, Caroline Mary, Philippe Juin, Nicolas Poirier, Sophie Barillé-Nion, Christophe Blanquart

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionTumor Associated Macrophages (TAM) are a major component of the tumor environment and their accumulation often correlates with poor prognosis by contributing to local inflammation, inhibition of anti-tumor immune response and resistance t

Externí odkaz: https://doaj.org/article/d99530eb600e4897901d77bbb348a2e0

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Akademický článek

STING-dependent paracriny shapes apoptotic priming of breast tumors in response to anti-mitotic treatment

Autor: Steven Lohard, Nathalie Bourgeois, Laurent Maillet, Fabien Gautier, Aurélie Fétiveau, Hamza Lasla, Frédérique Nguyen, Céline Vuillier, Alison Dumont, Agnès Moreau-Aubry, Morgane Frapin, Laurent David, Delphine Loussouarn, Olivier Kerdraon, Mario Campone, Pascal Jézéquel, Philippe P. Juin, Sophie Barillé-Nion

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Antimitotic compounds, such as paclitaxel, induce cell death in cycling cancer cells only. Here, the authors show that paclitaxel-targeted breast cancer cells prime neighboring cells to apoptosis through a STING-mediated paracrine signaling pathway.

Externí odkaz: https://doaj.org/article/0aa8ad60806d444b913612a87eb4037b

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Noxa the BCL-2 Family Member behind the Scenes in Cancer Treatment

Autor: Alison Dumont, Sophie Barillé-Nion, Laurent Maillet, Steven Lohard, Philippe Juin

Publikováno v: Journal of Cellular Signaling
Journal of Cellular Signaling, 2020, 1 (4), pp.127
Journal of Cellular Signaling, Scientific Archives, 2020, 1 (4), pp.127

International audience; NOXA is a critical mediator of stress responses to anticancer drugs. This BH3-only protein sets the apoptotic threshold in cancer cells in response to chemotherapies by counteracting the prosurvival BCL-2 family protein MCL-1.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a14d918c6ef2ee551a847b396de159f
https://www.hal.inserm.fr/inserm-03171678

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