Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Alison D. O'Brien"'
Autor:
Jocelyn R. Hauser, Rama R. Atitkar, Courtney D. Petro, Rebecca L. Lindsey, Nancy Strockbine, Alison D. O'Brien, Angela R. Melton-Celsa
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
In this study we compared nine Shiga toxin (Stx)-producing Escherichia coli O157:H7 patient isolates for Stx levels, stx-phage insertion site(s), and pathogenicity in a streptomycin (Str)-treated mouse model. The strains encoded stx2a, stx1a and stx2
Externí odkaz:
https://doaj.org/article/41d84196df414fd5a58a616245bdd075
Autor:
Nadia Boisen, Angela R. Melton-Celsa, Anne-Marie Hansen, Tonia Zangari, Mark A. Smith, Lisa M. Russo, Flemming Scheutz, Alison D. O’Brien, James P. Nataro
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
An O104:H4 Shiga toxin (Stx)-producing enteroaggregative Escherichia coli (EAEC) strain caused a large outbreak of bloody diarrhea and the hemolytic uremic syndrome in 2011. We previously developed an ampicillin (Amp)-treated C57BL/6 mouse model to m
Externí odkaz:
https://doaj.org/article/6e447c252dc643c2b11faf40247e6fc8
Publikováno v:
Toxins, Vol 7, Iss 6, Pp 2306-2320 (2015)
Shiga toxin (Stx) is an AB5 ribotoxin made by Stx-producing Escherichia coli (STEC). These organisms cause diarrhea, hemorrhagic colitis and the hemolytic uremic syndrome. STEC make two types of Stxs, Stx1 and/or Stx2. Stx2 has one prototype (a) and
Externí odkaz:
https://doaj.org/article/cf9e0ffa42d5448091014797f8f09e4b
Publikováno v:
Toxins, Vol 5, Iss 11, Pp 2074-2092 (2013)
Shiga toxin type 2dact (Stx2dact), an Stx2 variant originally identified from Escherichia coli O91:H21 strain B2F1, displays increased cytotoxicity after activation by elastase present in intestinal mucus. Activation is a result of cleavage of two am
Externí odkaz:
https://doaj.org/article/52e016e3c7c74d66abb701a48a88a5e1
Publikováno v:
Emerging Infectious Diseases, Vol 5, Iss 2, Pp 224-234 (1999)
Many emerging and reemerging bacterial pathogens synthesize toxins that serve as primary virulence factors. We highlight seven bacterial toxins produced by well-established or newly emergent pathogenic microbes. These toxins, which affect eukaryotic
Externí odkaz:
https://doaj.org/article/0e647ffa13c24495bbb977a672ba212c
Autor:
Jocelyn R, Hauser, Rama R, Atitkar, Courtney D, Petro, Rebecca L, Lindsey, Nancy, Strockbine, Alison D, O'Brien, Angela R, Melton-Celsa
Publikováno v:
Frontiers in Cellular and Infection Microbiology
In this study we compared nine Shiga toxin (Stx)-producing Escherichia coli O157:H7 patient isolates for Stx levels, stx-phage insertion site(s), and pathogenicity in a streptomycin (Str)-treated mouse model. The strains encoded stx2a, stx1a and stx2
Autor:
Zhi-Mei Liu, Angela R. Melton-Celsa, Mark A. Smith, Alison D. O'Brien, Eszter Trojnar, James F. Sinclair, Courtney D. Petro
Publikováno v:
Infection and Immunity. 87
Shiga toxin (Stx)-producing Escherichia coli (STEC) causes foodborne outbreaks of bloody diarrhea. There are two major types of immunologically distinct Stxs: Stx1a and Stx2a. Stx1a is more cytotoxic to Vero cells than Stx2a, but Stx2a has a lower 50
Autor:
Yuliya I. Seldina, Malik J. Raynor, Theresa M. Koehler, Christy L. Ventura, Jennifer M. Scarff, Alison D. O'Brien
Publikováno v:
Molecular Microbiology. 102:545-561
Summary AtxA is a critical transcriptional regulator of plasmid-encoded virulence genes in Bacillus anthracis. Bacillus cereus G9241, which caused an anthrax-like infection, has two virulence plasmids, pBCXO1 and pBC210, that each harbor toxin genes
Publikováno v:
Journal of Food Protection. 78:2085-2088
Shiga toxin (Stx)-producing Escherichia coli (STEC) strains are food- and waterborne pathogens that are often transmitted via beef products or fresh produce. STEC strains cause both sporadic infections and outbreaks, which may result in hemorrhagic c
Autor:
Christy L. Ventura, James M. Vergis, Stephanie L. Servetas, Courtney D. Petro, Yuliya I. Seldina, D. Scott Merrell, Alison D. O'Brien
Publikováno v:
Infection and Immunity. 86
Bacillus cereus G9241 caused a life-threatening anthrax-like lung infection in a previously healthy human. This strain harbors two large virulence plasmids, pBCXO1 and pBC210, that are absent from typical B. cereus isolates. The pBCXO1 plasmid is nea