Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Alison D. Clark"'
Autor:
Mikko Turunen, Jason M. Spaeth, Salla Keskitalo, Min Ju Park, Teemu Kivioja, Alison D. Clark, Netta Mäkinen, Fangjian Gao, Kimmo Palin, Helka Nurkkala, Anna Vähärautio, Mervi Aavikko, Kati Kämpjärvi, Pia Vahteristo, Chongwoo A. Kim, Lauri A. Aaltonen, Markku Varjosalo, Jussi Taipale, Thomas G. Boyer
Publikováno v:
Cell Reports, Vol 7, Iss 3, Pp 654-660 (2014)
Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at very high frequency (∼70%) in uterine leiomyomas. However, the influence of these mutations on Mediator function and the molecular basis for their
Externí odkaz:
https://doaj.org/article/59206a3393054e17a8c174a02fdf6b30
Autor:
Ralf Bützow, Pia Vahteristo, Salla Keskitalo, Susanna Lintula, Kristina Hotakainen, Tuomas Heikkinen, Heli Nevanlinna, Markku Varjosalo, Jussi Taipale, Thomas G. Boyer, Tapio Visakorpi, Alison D. Clark, Netta Mäkinen, Peter Hokland, Jan Böhm, Nam Hee Kim, Kati Kämpjärvi, Min Ju Park, Pernilla von Nandelstadh, Jukka-Pekka Mecklin, Mika Kontro, Tom Böhling, Kati Kivinummi, Mikko P. Turunen, Heikki Järvinen
Publikováno v:
The Prostate. 76:22-31
Background Mediator is a multiprotein interface between eukaryotic gene-specific transcription factors and RNA polymerase II. Mutations in exon 2 of the gene encoding MED12, a key subunit of the regulatory kinase module in Mediator, are extremely fre
Autor:
Alison D. Clark, Suleman S. Hussain, Shih-Bo Huang, Roble G. Bedolla, Mohammad A. Obeidat, Niko Papanikolaou, Chun Lin Lin, Tim H. Huang, Yogesh Gupta, Yidong Chen, Hiroshi Miyamoto, Rita Ghosh, Addanki P. Kumar
Publikováno v:
Cancer Research. 79:3943-3943
Radiation therapy (RT) is a standard treatment for organ confined prostate cancer (PCa). Although dose escalation increases local control, further escalation hampers effectiveness due to toxicity. Additionally, intrinsic and acquired resistance to ra
Autor:
Tom Böhling, Thomas G. Boyer, Heikki Järvinen, Jari Sjöberg, Pia Vahteristo, Kati Kämpjärvi, Ralf Bützow, Miika Mehine, Min Ju Park, Jan Böhm, Nam Hee Kim, Alison D. Clark, Jukka-Pekka Mecklin, Ian Tomlinson, Zephne M van der Spuy
Mediator regulates transcription by connecting gene-specific transcription factors to the RNA polymerase II initiation complex. We recently discovered by exome sequencing that specific exon 2 mutations in mediator complex subunit 12 (MED12) are extre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17698ebb2cd3bdf60f8ba49de28dd39f
https://ora.ox.ac.uk/objects/uuid:db178340-2489-4264-8657-901c72b89f52
https://ora.ox.ac.uk/objects/uuid:db178340-2489-4264-8657-901c72b89f52
Autor:
Kati, Kämpjärvi, Nam Hee, Kim, Salla, Keskitalo, Alison D, Clark, Pernilla, von Nandelstadh, Mikko, Turunen, Tuomas, Heikkinen, Min Ju, Park, Netta, Mäkinen, Kati, Kivinummi, Susanna, Lintula, Kristina, Hotakainen, Heli, Nevanlinna, Peter, Hokland, Tom, Böhling, Ralf, Bützow, Jan, Böhm, Jukka-Pekka, Mecklin, Heikki, Järvinen, Mika, Kontro, Tapio, Visakorpi, Jussi, Taipale, Markku, Varjosalo, Thomas G, Boyer, Pia, Vahteristo
Publikováno v:
Kämpjärvi, K, Kim, N H, Keskitalo, S, Clark, A D, von Nandelstadh, P, Turunen, M, Heikkinen, T, Park, M J, Mäkinen, N, Kivinummi, K, Lintula, S, Hotakainen, K, Nevanlinna, H, Hokland, P, Böhling, T, Bützow, R, Böhm, J, Mecklin, J-P, Järvinen, H, Kontro, M, Visakorpi, T, Taipale, J, Varjosalo, M, Boyer, T G & Vahteristo, P 2016, ' Somatic MED12 mutations in prostate cancer and uterine leiomyomas promote tumorigenesis through distinct mechanisms ', The Prostate, vol. 76, no. 1, pp. 22-31 . https://doi.org/10.1002/pros.23092
BACKGROUND: Mediator is a multiprotein interface between eukaryotic gene-specific transcription factors and RNA polymerase II. Mutations in exon 2 of the gene encoding MED12, a key subunit of the regulatory kinase module in Mediator, are extremely fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1584d9a1c9fc0651174c453f597f10d3
https://pure.au.dk/portal/da/publications/somatic-med12-mutations-in-prostate-cancer-and-uterine-leiomyomas-promote-tumorigenesis-through-distinct-mechanisms(7c0357f9-9a21-4af7-8e33-fbae6ab1fe2d).html
https://pure.au.dk/portal/da/publications/somatic-med12-mutations-in-prostate-cancer-and-uterine-leiomyomas-promote-tumorigenesis-through-distinct-mechanisms(7c0357f9-9a21-4af7-8e33-fbae6ab1fe2d).html
Publikováno v:
Cancer Research. 77:349-349
Eribulin provides a survival advantage for breast cancer patients, particularly those with triple-negative and HER2-negative subtypes.1,2 Mechanistically, eribulin was shown to reverse epithelial-to-mesenchymal transition (EMT) in breast cancer model
Autor:
Pia Vahteristo, Salla Keskitalo, Fangjian Gao, Kati Kämpjärvi, Netta Mäkinen, Chongwoo A. Kim, Jussi Taipale, Thomas G. Boyer, Anna Vähärautio, Alison D. Clark, Jason M. Spaeth, Markku Varjosalo, Mervi Aavikko, Helka Nurkkala, Mikko P. Turunen, Lauri A. Aaltonen, Kimmo Palin, Min Ju Park, Teemu Kivioja
Publikováno v:
Cell Reports
Cell Reports, Vol 7, Iss 3, Pp 654-660 (2014)
Cell Reports, Vol 7, Iss 3, Pp 654-660 (2014)
SummarySomatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at very high frequency (∼70%) in uterine leiomyomas. However, the influence of these mutations on Mediator function and the molecular basis for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64917591b3aa291da6835361da54187
http://hdl.handle.net/10138/165432
http://hdl.handle.net/10138/165432
The MED12/Cyclin C Interface as a Therapeutic Target in Oncogenic Wnt/Beta‐catenin signaling (LB285)
Publikováno v:
The FASEB Journal. 28
CDK8 is a colorectal cancer oncoprotein whose amplification-dependent overexpression identifies a significant subset of colorectal cancer patients with poor prognosis. Mechanistically, Cyclin C (CycC)-dependent CDK8 kinase drives tumorigenesis by reg
Autor:
Fangjian Gao, Marieke Oldenbroek, Alison D. Clark, Victor X. Jin, Yao Wang, Thomas G. Boyer, Jason M. Spaeth
Publikováno v:
Cancer Research. 76:4607-4607
Dysregulation of Wnt/β-catenin signaling promotes colorectal cancer (CRC) and other types of malignancies through unprogrammed changes in gene transcription that drive tumorigenesis. CDK8 is a CRC oncoprotein whose amplification-dependent overexpres