Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Alison D, Findlay"'
Autor:
Nutan Chaudhari, Alison D. Findlay, Andrew W. Stevenson, Tristan D. Clemons, Yimin Yao, Amar Joshi, Sepidar Sayar, Gordon Wallace, Suzanne Rea, Priyanka Toshniwal, Zhenjun Deng, Philip E. Melton, Nicole Hortin, K. Swaminathan Iyer, Wolfgang Jarolimek, Fiona M. Wood, Mark W. Fear
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Scars are a significant problem caused by excess collagen in the skin. Here the authors develop a topical drug that reduces collagen stability and leads to improved scar appearance and stiffness in preclinical models.
Externí odkaz:
https://doaj.org/article/c8f42b004a044203b08d7a2b33f65895
Autor:
Nutan Chaudhari, Alison D. Findlay, Andrew W. Stevenson, Tristan D. Clemons, Yimin Yao, Amar Joshi, Sepidar Sayyar, Gordon Wallace, Suzanne Rea, Priyanka Toshniwal, Zhenjun Deng, Philip E. Melton, Nicole Hortin, K. Swaminathan Iyer, Wolfgang Jarolimek, Fiona M. Wood, Mark W. Fear
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/6ec0d2fc95844e03a9d3ce21271b20a1
Autor:
Zhou Wenbin, Mary Brock, Heidi Schilter, Mandar Deodhar, Lara Perryman, Jessica Stolp, Craig Ivan Turner, Dieter Hamprecht, Brett Charlton, Yimin Yao, Wolfgang Jarolimek, Christina Raso, Ross Hamilton, Jonathan Stuart Foot, Marie Galati, Alison D. Findlay, Amna Zahoor
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 11, Pp n/a-n/a (2021)
Clinical and Translational Medicine
Clinical and Translational Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3de0ce4b9cdc8a367fdf85379b88be7
https://doaj.org/article/c99b1b5618214a2193bedd33dab46b7d
https://doaj.org/article/c99b1b5618214a2193bedd33dab46b7d
Autor:
Jonathan S, Foot, Alberto, Buson, Mandar, Deodhar, Alison D, Findlay, Alan D, Robertson, Craig I, Turner, Tin, Yow, Wenbin, Zhou, Wolfgang, Jarolimek
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 74:128942
The discovery of a dual MAO-B/SSAO inhibitor PXS-5131 is reported. The compound offers a compact and rigid three-dimensional structure with superior selectivity over MAO-A. Potency and selectivity are linked to both the double bond geometry and stere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4c64f7cbe0681ee40033a81278070c
https://doi.org/10.1016/j.bmcl.2022.128942
https://doi.org/10.1016/j.bmcl.2022.128942
Autor:
Orly Leiva, Alison D. Findlay, Shinobu Matsuura, Vipul C. Chitalia, Hector A. Lucero, Seng Kah Ng, Wolfgang Jarolimek, Katya Ravid, Craig Ivan Turner
Publikováno v:
Int J Hematol
Primary myelofibrosis (PMF) is a chronic myeloproliferative neoplasm (MPN) that usually portends a poor prognosis with limited therapeutic options available. Currently only allogeneic stem cell transplantation is curative in those who are candidates,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6106c3bc6f8f56a4e1b8a78e82cca5a0
https://doi.org/10.1007/s12185-019-02751-6
https://doi.org/10.1007/s12185-019-02751-6
Publikováno v:
Anti-fibrotic Drug Discovery ISBN: 9781788015103
The hallmark of fibrosis is the accumulation of excessive collagen in tissue as a result of an imbalance between collagen formation and degradation. A key step in collagen formation is its stabilization – and with this, slowing of its degradation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d159c3af0e387ba4e968c189bceb4887
https://doi.org/10.1039/9781788015783-00145
https://doi.org/10.1039/9781788015783-00145
Autor:
Wolfgang Jarolimek, Andrew G. Jarnicki, Heidi Schilter, Jonathan Stuart Foot, Philip M. Hansbro, Craig Ivan Turner, Zhou Wenbin, Mandar Deodhar, Gang Liu, Alison D. Findlay, Alberto Buson
Publikováno v:
Journal of medicinal chemistry. 62(21)
Lysyl oxidase-like 2 (LOXL2) is a secreted enzyme that catalyzes the formation of cross-links in extracellular matrix proteins, namely, collagen and elastin, and is indicated in fibrotic diseases. Herein, we report the identification and subsequent o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75af825d7a51df8d8363f42172222091
https://pubmed.ncbi.nlm.nih.gov/31580073
https://pubmed.ncbi.nlm.nih.gov/31580073
Autor:
Amna Zahoor, Craig Ivan Turner, Heidi Schilter, Greco Angelique Elsa, Joshua Moses, Tin T Yow, Wolfgang Jarolimek, Zhou Wenbin, Mandar Deodhar, Alberto Buson, Sarah Townsend, Lara Perryman, Benjamin S. Rayner, Jonathan Stuart Foot, Alison D. Findlay, Amar Joshi
Publikováno v:
Journal of Cellular and Molecular Medicine
Fibrosis is characterized by the excessive deposition of extracellular matrix and crosslinked proteins, in particular collagen and elastin, leading to tissue stiffening and disrupted organ function. Lysyl oxidases are key players during this process,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245fc3c8e82e47bdc6eb220ffe538eb3
https://pubmed.ncbi.nlm.nih.gov/30536539
https://pubmed.ncbi.nlm.nih.gov/30536539
Autor:
Brett D. Schwartz, Jiri Mikusek, Jeremy Nugent, Jonathan Stuart Foot, Martin G. Banwell, Alison D. Findlay, Jas S. Ward
Publikováno v:
Organic letters. 20(13)
The synthesis of the structure, 1, assigned to the anti-inflammatory natural product myrsinoic acid F is reported together with a means for preparing its Z-isomer 21. While neither of these compounds corresponds to the natural product, both of them a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66502d0a7833d9f98e8bc43b239fe701
https://pubmed.ncbi.nlm.nih.gov/29888922
https://pubmed.ncbi.nlm.nih.gov/29888922
Autor:
Thomas R. Cox, Paul Timpson, Lidia E. Leonte, Lukram Babloo Singh, Wolfgang Jarolimek, Joan Chang, Janine T. Erler, Morghan C. Lucas, Jonathan S. Foot, Mandar Deodhar, Marc Garcia-Montolio, Alison D. Findlay
Publikováno v:
Chang, J, Lucas, M C, Leonte, L E, Garcia-Montolio, M, Singh, L B, Findlay, A D, Deodhar, M, Foot, J S, Jarolimek, W, Timpson, P, Erler, J T & Cox, T R 2017, ' Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer ', Oncotarget . https://doi.org/10.18632/oncotarget.15257
Chang, J, Lucas, M C, Leonte, L E, Garcia-Montolio, M, Singh, L B, Findlay, A D, Deodhar, M, Foot, J S, Jarolimek, W, Timpson, P, Erler, J T & Cox, T R 2017, ' Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer ', OncoTarget, vol. 8, no. 16, pp. 26066-26078 . https://doi.org/10.18632/oncotarget.15257
Oncotarget
Chang, J, Lucas, M C, Leonte, L E, Garcia-Montolio, M, Singh, L B, Findlay, A D, Deodhar, M, Foot, J S, Jarolimek, W, Timpson, P, Erler, J T & Cox, T R 2017, ' Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer ', OncoTarget, vol. 8, no. 16, pp. 26066-26078 . https://doi.org/10.18632/oncotarget.15257
Oncotarget
// Joan Chang 1 , Morghan C. Lucas 2 , Lidia E. Leonte 1 , Marc Garcia-Montolio 1 , Lukram Babloo Singh 1 , Alison D. Findlay 3 , Mandar Deodhar 3 , Jonathan S. Foot 3 , Wolfgang Jarolimek 3 , Paul Timpson 2 , Janine T. Erler 1 , Thomas R. Cox 1, 2 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d1ecaaf3616c775c04eb52cde9a905
https://doi.org/10.18632/oncotarget.15257
https://doi.org/10.18632/oncotarget.15257