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Autor:
Ayyoub Selka, Sandra Turcotte, Pierre J. Lyons, Alison Chiasson, Marc E. Surette, Mohamed Touaibia, Marc Cormier, Sonia Dastous, Jérémie A. Doiron
Publikováno v:
European Journal of Medicinal Chemistry. 179:347-357
The inhibition of 5-lipoxygenase (5-LO), the key enzyme for the biosynthesis of leukotrienes (LTs), has generated increasing enthusiasm as anti-inflammatory and antitumor strategies in recent years. Based on our previous studies, we synthesized a ser