Výsledky vyhledávání - "Alison Cartwright"

Is Chemokine Receptor CCR9 Required for Synovitis in Rheumatoid Arthritis? Deficiency of CCR9 in a Murine Model of Antigen-Induced Arthritis

Autor: Jim Middleton, Oksana Kehoe, Alison Cartwright, Sophie King

Publikováno v: Open Journal of Rheumatology and Autoimmune Diseases. :77-84

Objectives: Monocytes/macrophages accumulate in the synovial membrane in rheumatoid arthritis and play a key role in disease pathogenesis, contributing to inflammation, cartilage destruction and bone erosion. Identification of molecules involved in m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::569f5314e9a6463c43786004ee73cb29
https://doi.org/10.4236/ojra.2012.24015

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Role of Coordination Geometry in Dictating the Barrier to Hydride Migration in d6 Square-Pyramidal Iridium and Rhodium Pincer Complexes

Autor: Cynthia K. Schauer, Michael Findlater, Maurice Brookhart, Alison Cartwright-Sykes, Peter S. White

Publikováno v: Journal of the American Chemical Society. 133:12274-12284

Syntheses of the olefin hydride complexes [(POCOP)M(H)(olefin)][BAr(f)(4)] (6a-M, M = Ir or Rh, olefin = C(2)H(4); 6b-M, M = Ir or Rh, olefin = C(3)H(6); POCOP = 2,6-bis(di-tert-butylphosphinito)benzene; BAr(f) = tetrakis(3,5-trifluoromethylphenyl)bo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec439f70f36e85ac79e89264ba0e5fdc
https://doi.org/10.1021/ja204851x

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Differential expression of syndecans and glypicans in chronically inflamed synovium

Autor: Guido David, Alison Cartwright, Angela M. Patterson, Barry Bresnihan, B A Ashton, Jim Middleton, Oliver FitzGerald

Publikováno v: Annals of the Rheumatic Diseases

Background: Membrane-bound heparan sulphate proteoglycans (HSPGs) act as coreceptors and presenters of cytokines and are involved in cell-matrix and cell-cell adhesion. Objective: To investigated which HSPGs are expressed in knee joint synovia from p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4746ed196ec2d0b4d01af71251a050e2
https://doi.org/10.1136/ard.2006.063875

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Effects of High Molecular Weight Hyaluronan on Chondrocytes Cultured within a Resorbable Gelatin Sponge

Autor: B A Ashton, Nicola J. Goodstone, Alison Cartwright

Publikováno v: Tissue Engineering. 10:621-631

Freshly isolated bovine articular chondrocytes were seeded into a resorbable gelatin sponge and cultured in the absence or presence of extrinsic high molecular weight hyaluronan (HA) for up to 1 month. The gelatin sponge could be uniformly and reprod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1054aaffa7d657ace931a4161e8563
https://doi.org/10.1089/107632704323061979

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Intra-articular injection of mesenchymal stem cells leads to reduced inflammation and cartilage damage in murine antigen-induced arthritis

Autor: Oksana, Kehoe, Alison, Cartwright, Ayman, Askari, Alicia J, El Haj, Jim, Middleton

Publikováno v: Journal of Translational Medicine

Background Rheumatoid arthritis (RA) is a debilitating and painful disease leading to increased morbidity and mortality and novel therapeutic approaches are needed. The purpose of this study was to elucidate if mesenchymal stem cells (MSCs) injected

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f838a059d3cbb26c9c3d03cdf95e22d9
https://pubmed.ncbi.nlm.nih.gov/24893776

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Orphan receptor GPR15/BOB is up-regulated in rheumatoid arthritis

Autor: Alison, Cartwright, Caroline, Schmutz, Ayman, Askari, Jan-Herman, Kuiper, Jim, Middleton

Publikováno v: Cytokine

Highlights • Expression of orphan receptor GPR15/BOB was examined in RA and non-RA subjects. • GPR15/BOB protein was observed on macrophages in synovia and increased in RA. • GPR15/BOB messenger RNA was detected in all RA and a minority of non-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f7987ba9ba8dab7703f315dbb3231b3
https://pubmed.ncbi.nlm.nih.gov/24725539

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Dihydrogen complexes of iridium and rhodium

Autor: Katherine M. Schultz, Wesley H. Bernskoetter, Michael Findlater, Alison Cartwright-Sykes, D. Michael Heinekey, Maurice Brookhart

Publikováno v: Inorganic chemistry. 51(8)

A series of iridium and rhodium pincer complexes have been synthesized and characterized: [(POCOP)Ir(H)(H(2))] [BAr(f)(4)] (1-H(3)), (POCOP)Rh(H(2)) (2-H(2)), [(PONOP)Ir(C(2)H(4))] [BAr(f)(4)] (3-C(2)H(4)), [(PONOP)Ir(H)(2))] [BAr(f)(4)] (3-H(2)), [(

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d19b7ed08e761d3098655316f03fc56d
https://pubmed.ncbi.nlm.nih.gov/22364621

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Reactions of Anilines and Benzamides with a 14-Electron Iridium(I) Bis(phosphinite) Complex: N−H Oxidative Addition versus Lewis Base Coordination

Autor: Sykes, Alison Cartwright, White, Peter, Brookhart, Maurice

Anilines react with (POCOP)Ir(C6H5)(H), 12, (POCOP = 2,6-(OPtBu2)2C6H3) to yield equilibrium mixtures of 12, the Ir(I) σ-complexes (POCOP)Ir(NH2Ar), 13, and the Ir(III) oxidative addition adducts (POCOP)Ir(H)(NHAr), 14. Quantitative studies of these

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::396e59af744cf1f2d6314855285f8821

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Investigations of C-H and N-H activation with electron deficient iridium pincer complexes

Autor: Sykes, Alison Cartwright

Transition metal reactions that involve C-H and N-H bond activation provide a potential method for functionalizing hydrocarbons and amines. For the past three decades there have been numerous advances in this field; however, developing new approaches

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eff3c36abf34ca79170f1d7d64fe0347

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