Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Alison Capolino"'
Autor:
Richard M. Nelson, Emeigh Jonathan Emilian, Terence A. Kelly, Gregory W. Peet, Eugene R. Hickey, Jiang-Ping Wu, Jun Li, Clare Zimmitti, Janice R. Brickwood, John D. Ginn, Charles L. Cywin, Melissa Foerst, David Stefany, Erika Scouten, Roman Wolfgang Fleck, Zhidong Chen, Mohammed A. Kashem, Daniel Richard Marshall, Steve M. Weldon, Ming-Hong Hao, Weimin Liu, Matt Hrapchak, Catron Katrina Mary, Ian Potocki, Tina Morwick, Peter Allen Nemoto, Michel Liuzzi, Leslie Martin, Denise Spero, Alison Capolino, Michael Robert Turner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5547-5551
An SAR study that identified a series of thienopyridine-based potent IkappaB Kinase beta (IKKbeta) inhibitors is described. With focuses on the structural optimization at C4 and C6 of structure 1 (Fig. 1), the study reveals that small alkyl and certa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bf342a17513439f8b8c45db25f9d37
https://doi.org/10.1016/j.bmcl.2009.08.054
https://doi.org/10.1016/j.bmcl.2009.08.054
Autor:
Jessi Wildeson Jones, Gregory W. Peet, Joseph R. Woska, Anthony Shrutkowski, Lore Gruenbaum, Alison Capolino, Christopher Pargellis, Racheline Schwartz, Rodney P. DeLeon, Maurice M. Morelock, Lisa Mara, Thomas C. Warren
Publikováno v:
Biochemical pharmacology. 77(3)
The characterization of the potent p38 inhibitor BIRB796 as a dual inhibitor of p38/Jun N-terminal kinases (JNK) mitogen-activated protein kinases (EC 2.7.11.24) has complicated the interpretation of its reported anti-inflammatory activity. To better
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d98ce811f8fcdaf671f3c3094154b94
https://pubmed.ncbi.nlm.nih.gov/19027720
https://pubmed.ncbi.nlm.nih.gov/19027720
Autor:
Paul Kaplita, Lisa Liu, Richard M. Nelson, Gilmore Thomas A, Gerald Nabozny, Donna Terenzio, Susan E. Goldrick, Alison Capolino, John R. Proudfoot, Ji Wang, David S. Thomson, Younes Bekkali, Hidenori Takahashi, Ljiljana Zuvela-Jelaska
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(18)
We have recently reported the discovery of a novel class of glucocorticoid receptor (GR) antagonists, exemplified by 3, containing a 1,2-dihydroquinoline molecular scaffold. Further SAR studies of these antagonists uncovered chemical modifications co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5b69ff5b2ebee4dc86945c3bb7e0dc
https://pubmed.ncbi.nlm.nih.gov/17681466
https://pubmed.ncbi.nlm.nih.gov/17681466