Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alison C. Savage"'
Autor:
Rahul P. Bakshi, Lee M. Tatham, Alison C. Savage, Abhai K. Tripathi, Godfree Mlambo, Matthew M. Ippolito, Elizabeth Nenortas, Steve P. Rannard, Andrew Owen, Theresa A. Shapiro
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Long-acting antimalarials could provide improved prophylaxis and treatment options in the field. Here, Bakshi et al. develop a long-acting injectable atovaquone nanomedicine that prevents malaria infection prophylactically for up to 4 weeks in mice w
Externí odkaz:
https://doaj.org/article/e2bbca833b9043c393d3ffbbdc23b805
Publikováno v:
Toxins, Vol 7, Iss 5, Pp 1544-1555 (2015)
Botulinum neurotoxin is one of the deadliest biological toxins known to mankind and is able to cause the debilitating disease botulism. The rapid detection of the different serotypes of botulinum neurotoxin is essential for both diagnosis of botulism
Externí odkaz:
https://doaj.org/article/729f4c80c2a04853a61ec01c45709b9a
Publikováno v:
Sensing and Bio-Sensing Research, Vol 2, Iss C, Pp 12-15 (2014)
The standard method for the detection of botulinum neurotoxin is currently the mouse bioassay which is considered to be the most reliable method for the detection of the active form of this toxin. Despite this it is a time-consuming and expensive ass
Externí odkaz:
https://doaj.org/article/e3f21f039d1a486e9397ba966e81d98e
Autor:
Marco Siccardi, Paul Curley, Steve P. Rannard, Andrew Owen, Alison C. Savage, James J. Hobson, Charles Flexner, Amer Al-khouja, Caren L. Freel Meyers
Publikováno v:
Nanoscale Advances. 1:4301-4307
The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ad4baa319f4588d7efe05db0c90d011
https://doi.org/10.1039/c9na00529c
https://doi.org/10.1039/c9na00529c
Autor:
James J. Hobson, Paul Curley, A. B. Dwyer, Usman Arshad, Helen Box, Andrew Owen, Henry Pertinez, Christopher David, Tom O. McDonald, Neill J. Liptrott, Jonathan Massam, Alison C. Savage, Joanne Sharp, Steve P. Rannard, Rajith K. R. Rajoli, Megan Neary, Anthony Valentijn, Catherine Unsworth, Lee Tatham
Publikováno v:
Nanoscale. 13(13)
The control of COVID-19 across the world requires the formation of a range of interventions including vaccines to elicit an immune response and immunomodulatory or antiviral therapeutics. Here, we demonstrate the nanoparticle formulation of a highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c545d76f781bdecb39e3ee00816ac39e
https://pubmed.ncbi.nlm.nih.gov/33885522
https://pubmed.ncbi.nlm.nih.gov/33885522
Autor:
Steve P. Rannard, Matthew M. Ippolito, Abhai K. Tripathi, Lee Tatham, Alison C. Savage, Andrew Owen, Elizabeth Nenortas, Godfree Mlambo, Rahul P. Bakshi, Theresa A. Shapiro
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
Nature Communications
Nature Communications
Chemoprophylaxis is currently the best available prevention from malaria, but its efficacy is compromised by non-adherence to medication. Here we develop a long-acting injectable formulation of atovaquone solid drug nanoparticles that confers long-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a839c29fb5193edfb368f24ebd83090e
https://doaj.org/article/e2bbca833b9043c393d3ffbbdc23b805
https://doaj.org/article/e2bbca833b9043c393d3ffbbdc23b805
Autor:
Andrew Owen, Lee Tatham, Trevor Scott, Steven Paul Rannard, Marco Siccardi, A. B. Dwyer, Andrew Clark, Alison C. Savage, Manoli Vourvahis
Publikováno v:
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Suboptimal adherence to antiretroviral (ARV) therapy can lead to insufficient drug exposure leading to viral rebound and increased likelihood of resistance. This has driven the development of long-acting injectable (LAI) formulations which may mitiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a6f1e631de49ae4ea532590204b701
Autor:
Andrew Owen, Manoli Vourvahis, Alison C. Savage, Steve P. Rannard, Andrew Clark, Lee Tatham, Trevor Scott, Marco Siccardi
Publikováno v:
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
Oral drug administration remains the preferred approach for treatment of HIV in most patients. Maraviroc (MVC) is the first in class co-receptor antagonist, which blocks HIV entry into host cells. MVC has an oral bioavailability of approximately 33%,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d970030930c8f96c28b30972971afe92
https://pubmed.ncbi.nlm.nih.gov/29777772
https://pubmed.ncbi.nlm.nih.gov/29777772
Publikováno v:
Toxins
Volume 7
Issue 5
Pages 1544-1555
Toxins, Vol 7, Iss 5, Pp 1544-1555 (2015)
Volume 7
Issue 5
Pages 1544-1555
Toxins, Vol 7, Iss 5, Pp 1544-1555 (2015)
Botulinum neurotoxin is one of the deadliest biological toxins known to mankind and is able to cause the debilitating disease botulism. The rapid detection of the different serotypes of botulinum neurotoxin is essential for both diagnosis of botulism
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e44f9ae3acf10b2a9bfab6cdebe3573
http://europepmc.org/articles/PMC4448162
http://europepmc.org/articles/PMC4448162
Publikováno v:
Sensing and Bio-Sensing Research, Vol 2, Iss C, Pp 12-15 (2014)
The standard method for the detection of botulinum neurotoxin is currently the mouse bioassay which is considered to be the most reliable method for the detection of the active form of this toxin. Despite this it is a time-consuming and expensive ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::416d6a2e41d4798974297c6060410590
https://doi.org/10.1016/j.sbsr.2014.08.002
https://doi.org/10.1016/j.sbsr.2014.08.002