Clearance and toxicity of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHu GDNF) following acute convection-enhanced delivery into the striatum.

Autor: Hannah Taylor, Neil Barua, Alison Bienemann, Marcella Wyatt, Emma Castrique, Rebecca Foster, Matthias Luz, Christian Fibiger, Erich Mohr, Steven Gill

Publikováno v: PLoS ONE, Vol 8, Iss 3, p e56186 (2013)

BACKGROUND: Despite promising early results, clinical trials involving the continuous delivery of recombinant methionyl human glial cell line-derived neurotrophic factor (r-metHuGDNF) into the putamen for the treatment of Parkinson's disease have sho

Externí odkaz: https://doaj.org/article/da51f87d44c14703ae57bb88d2c36b1e

Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue

Autor: Lyudmila Turyanska, Vahid Heravi Shargh, Tracey D. Bradshaw, Stephen Lowis, William G B Singleton, Kaouthar Bouzinab, Malcolm F. G. Stevens, Beth Coyle, Stephen J. Paisey, Jeni Luckett, Alison Bienemann, Pavel Gershkovich

Publikováno v: Heravi Shargh, V, Luckett, J, Bouzinab, K, Paisey, S, Turyanska, L, Singleton, W G B, Lowis, S, Gershkovich, P, Bradshaw, T D, Stevens, M F G, Bienemann, A & Coyle, B 2021, ' Chemosensitization of Temozolomide-Resistant Pediatric Diffuse Midline Glioma Using Potent Nanoencapsulated Forms of a N(3)-Propargyl Analogue ', ACS Applied Materials and Interfaces, vol. 13, no. 30, pp. 35266-35280 . https://doi.org/10.1021/acsami.1c04164

The lack of clinical response to the alkylating agent temozolomide (TMZ) in pediatric diffuse midline/intrinsic pontine glioma (DIPG) has been associated with O6-methylguanine-DNA-methyltransferase (MGMT) expression and mismatch repair deficiency. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6e679b6a242c9fb83cebef85c9453ba
https://hdl.handle.net/1983/745b798e-33b5-4584-be14-1e222fa29cc9

Maximising coverage of brain structures using controlled reflux, convection-enhanced delivery and the recessed step catheter

Autor: Julia Fletcher, Owen Lewis, Mariusz Pietrzyk, David Johnson, Max Woolley, Alison Bienemann, Steven S Gill, Neil U Barua, Johnathan Fenech, Samuel Lewin Evans, William G B Singleton

Publikováno v: Lewis, O, Woolley, M, Johnson, D E, Fletcher, J, Fenech, J, Pietrzyk, M W, Barua, N U, Bienemann, A S, Singleton, W, Evans, S L & Gill, S S 2018, ' Maximising coverage of brain structures using controlled reflux, convection-enhanced delivery and the recessed step catheter ', Journal of Neuroscience Methods, vol. 308, pp. 337-345 . https://doi.org/10.1016/j.jneumeth.2018.08.029

BACKGROUND: The design and use of convection-enhanced delivery catheters remains an active field as clinical trials have highlighted suboptimal distribution as a contributory factor to the failure of those studies. Recent studies indicate limitations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db63a317aca20c963b9268da7e46e02
https://doi.org/10.1016/j.jneumeth.2018.08.029

An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against MDR Gram-negative bacteria: an in vitro and in vivo study

Autor: Ian Scott, William G B Singleton, Katherine Fowkes, Waheed Ashraf, Roger Bayston, Ivan Pelegrin, Alison Bienemann

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Journal of Antimicrobial Chemotherapy
Bayston, R, Ashraf, W, Pelegrin, I, Fowkes, K, Bienemann, A S, Singleton, W G B & Scott, I S 2019, ' An external ventricular drainage catheter impregnated with rifampicin, trimethoprim and triclosan, with extended activity against MDR Gram-negative bacteria : an in vitro and in vivo study ', Journal of Antimicrobial Chemotherapy, vol. 74, no. 10, dkz293, pp. 2959-2964 . https://doi.org/10.1093/jac/dkz293

Background External ventricular drainage (EVD) carries a high risk of ventriculitis, increasingly caused by MDR Gram-negative bacteria such as Escherichia coli and Acinetobacter baumannii. Existing antimicrobial EVD catheters are not effective agains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da10fe84dc060efbca8e0e7550a1cfb2
http://hdl.handle.net/2445/171215

Combined use of CDK4/6 and mTOR inhibitors induce synergistic growth arrest of diffuse intrinsic pontine glioma cells via mutual downregulation of mTORC1 activity

Autor: Neil U Barua, Lisa J. Boulter, Steven S Gill, Daniel J. Asby, Alison Bienemann, Claire Asby, Marcella J Wyatt, Clare L Killick-Cole, William G B Singleton

Publikováno v: Asby, D, Killick-Cole, C, Boulter, L, Singleton, W, Asby, C, Wyatt, M, Barua, N, Bienemann, A & Gill, S 2018, ' Combined use of CDK4/6 and mTOR inhibitors induce synergistic growth arrest of diffuse intrinsic pontine glioma cells via mutual downregulation of mTORC1 activity ', Cancer Management and Research, vol. 10, pp. 3483-3500 . https://doi.org/10.2147/CMAR.S167095

Daniel J Asby,1 Clare L Killick-Cole,1 Lisa J Boulter,1 William GB Singleton,1,2 Claire A Asby,3 Marcella J Wyatt,1 Neil U Barua,1,2 Alison S Bienemann,1 Steven S Gill1,2 1Functional Neurosurgery Research Group, Translational Health Sciences, Bristol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fdb65448a5314dd7979fcf12de3c849
https://www.dovepress.com/combined-use-of-cdk46-and-mtor-inhibitors-induce-synergistic-growth-ar-peer-reviewed-article-CMAR