Výsledky vyhledávání - "Alison Barkhymer"

Akademický článek

SARS-CoV-2 spike protein-mediated cardiomyocyte fusion may contribute to increased arrhythmic risk in COVID-19.

Autor: Daniel J Clemens, Dan Ye, Wei Zhou, C S John Kim, David R Pease, Chanakha K Navaratnarajah, Alison Barkhymer, David J Tester, Timothy J Nelson, Roberto Cattaneo, Jay W Schneider, Michael J Ackerman

Publikováno v: PLoS ONE, Vol 18, Iss 3, p e0282151 (2023)

BackgroundSARS-CoV-2-mediated COVID-19 may cause sudden cardiac death (SCD). Factors contributing to this increased risk of potentially fatal arrhythmias include thrombosis, exaggerated immune response, and treatment with QT-prolonging drugs. However

Externí odkaz: https://doaj.org/article/440f5ef93d77450fb80863bb29fc0742

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Primary infection with Zika virus provides one-way heterologous protection against Spondweni virus infection in rhesus macaques

Autor: Anna S. Jaeger, Chelsea M. Crooks, Andrea M. Weiler, Mason I. Bliss, Sierra Rybarczyk, Alex Richardson, Morgan Einwalter, Eric Peterson, Saverio Capuano, Alison Barkhymer, Jordan T. Becker, Joseph T. Greene, Tanya S. Freedman, Ryan A. Langlois, Thomas C. Friedrich, Matthew T. Aliota

Spondweni virus (SPONV) is the closest known relative of Zika virus (ZIKV). SPONV pathogenesis resembles that of ZIKV in pregnant mice, and both viruses are transmitted byAedes aegyptimosquitoes. We aimed to develop a translational model to further u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ef5a09d6a66444880fd070933b6fec4
https://doi.org/10.1101/2022.12.16.520792

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Highly Efficient SARS-CoV-2 Infection of Human Cardiomyocytes: Spike Protein-Mediated Cell Fusion and Its Inhibition

Autor: Chanakha K. Navaratnarajah, Trace A. Christensen, Jon E. Charlesworth, Roberto Cattaneo, Yoshihiro Kawaoka, Alison Barkhymer, Peter Halfmann, Kyle G. Howell, David R. Pease, Jay W. Schneider, Biruhalem Taye

Publikováno v: Journal of Virology

Severe cardiovascular complications can occur in coronavirus disease of 2019 (COVID-19) patients. Cardiac damage is attributed mostly to the aberrant host response to acute respiratory infection. However, direct infection of cardiac tissue by severe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb6fe7174a17f18c9ac9f38bdc0d675
http://europepmc.org/articles/PMC8610601

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Highly efficient SARS-CoV-2 infection of human cardiomyocytes: spike protein-mediated cell fusion and its inhibition

Autor: Alison Barkhymer, Frank J. Secreto, Boyd Rasmussen Timothy J. Nelson, David R. Pease, Chanakha K. Navaratnarajah, Kyle G. Howell, Jay W. Schneider, Trace A. Christensen, Yoshihiro Kawaoka, Jon E. Charlesworth, Wanek Family Program for HLHS-Stem Cell Pipeline, Biruhalem Taye, Roberto Cattaneo, Peter Halfmann

Severe cardiovascular complications can occur in coronavirus disease of 2019 (COVID-19) patients. Cardiac damage is attributed mostly to a bystander effect: the aberrant host response to acute respiratory infection. However, direct infection of cardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6272bfb68d5c3040a37c85ade3f35e2f
https://doi.org/10.1101/2021.07.30.454437

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SARS-CoV-2 direct cardiac damage through spike-mediated cardiomyocyte fusion

Viruses spread between hosts through particles, but within hosts, viral genomes can spread from cell to cell through fusion, evading antiviral defenses and obviating costly infectious virion production1-3. Billions of electromechanically coupled card

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abd2b3bd52248609f5c69dc47033c120
https://doi.org/10.21203/rs.3.rs-95587/v1

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