Immune correlates analysis of the Imbokodo (HVTN 705/HPX2008) efficacy trial of a mosaic HIV-1 vaccine regimen evaluated in Southern African people assigned female sex at birth: a two-phase case-control studyResearch in context

Autor: Avi Kenny, Janine van Duijn, One Dintwe, Jack Heptinstall, Randy Burnham, Sheetal Sawant, Lu Zhang, Dieter Mielke, Sharon Khuzwayo, Faatima Laher Omar, Sherry Stanfield-Oakley, Taylor Keyes, Brooke Dunn, Derrick Goodman, Youyi Fong, David Benkeser, Rodger Zou, John Hural, Ollivier Hyrien, Michal Juraska, Alex Luedtke, Lars van der Laan, Elena E. Giorgi, Craig Magaret, Lindsay N. Carpp, Laura Pattacini, Tom van de Kerkhof, Bette Korber, Wouter Willems, Leigh H. Fisher, Hanneke Schuitemaker, Edith Swann, James G. Kublin, Maria G. Pau, Susan Buchbinder, Frank Tomaka, Steven Nijs, Ludo Lavreys, Huub C. Gelderblom, Lawrence Corey, Kathryn Mngadi, Glenda E. Gray, Erica Borducchi, Jenny Hendriks, Kelly E. Seaton, Susan Zolla-Pazner, Dan H. Barouch, Guido Ferrari, Stephen C. De Rosa, M Juliana McElrath, Erica Andersen-Nissen, Daniel J. Stieh, Georgia D. Tomaras, Peter B. Gilbert, Jon Allagappen, Jessica Andriesen, Alison Ayres, Saman Baral, Linda-Gail Bekker, Asiphe Besethi, Caroline Borremans, Esmee Braams, Caroline Brackett, William Brumskine, Roma Chilengi, Rachel Choi, Thozama Dubula, Jaiden Seongmi Dumas, Radhika Etikala, Zelda Euler, Sarah Everett, Nigel Garrett, Huub Gelderblom, Katherine Gill, Kevin Gillespie, Dimitri Goedhart, Erik Goosmann, Shannon Grant, Ellie Hands, Barton Haynes, Bronwill Herringer, Zaheer Hoosain, Mina Hosseinipour, Portia Hunidzarira, Julia Hutter, Mubiana Inambao, Craig Innes, William Kilembe, Philippus Kotze, Sheena Kotze, Fatima Laher, Imre Laszlo, Erica Lazarus, Hua-Xin Liao, Yong Lin, Helen Lu, Judith Lucas, Mookho Malahleha, Tara McNair, Peter Meerts, Zinhle Mgaga, Mahlodi Montlha, Boitumelo Mosito, Andrew Moultrie, Sarah Mudrak, Valérie Oriol-Mathieu, Marcella Sarzotti-Kelsoe, Matson Tso Mathebula, Mitch Matoga, Rachael McClennen, Pamela Mda, Vimla Naicker, Logashvari Naidoo, Cindy-Ann Okkers, Saleha Omarjee, Hella Pasmans, Tricia Philip, Abraham Pinter, Annah Pitsi, Ornelia Ramos, April Randhawa, Sanne Roels, Shamiska Rohith, Lucy Rutten, Jerald Sadoff, Gabriela Salinas, Yvonne Salzgeber, Lorenz Scheppler, Katharine Schwedhelm, Nicolette Schuller, Angelina Sharak, Carrie Sopher, Terence Tafatatha, Simbarashe G. Takuva, Chan Tang, An Vandebosch, Edna Viegas, Valentin Voillet, Frank Wegmann, Mo Weijtens, Stephany Wilcox, Anthony Williams, Chenchen Yu, Pei-Chun Yu, Olive Yuan, Xuehan Zhang

Publikováno v: EBioMedicine, Vol 108, Iss , Pp 105320- (2024)

Summary: Background: The HVTN 705 Imbokodo trial of 2636 people without HIV and assigned female sex at birth, conducted in southern Africa, evaluated a heterologous HIV-1 vaccine regimen: mosaic adenovirus 26-based vaccine (Ad26.Mos4.HIV) at Months 0

Externí odkaz: https://doaj.org/article/f41b2bdf77344ddab5c165f46025f8a4

White Matter Hyperintensities and Blood Pressure Lowering in Acute Intracerebral Hemorrhage: A Secondary Analysis of the ATACH-2 Trial

Autor: Andrea, Morotti, Ashkan, Shoamanesh, Jamary, Oliveira-Filho, Frieder, Schlunk, Javier M, Romero, Michael, Jessel, Alison, Ayres, Anastasia, Vashkevich, Kristin, Schwab, Christy, Cassarly, Renee' Hebert, Martin, Steven M, Greenberg, Adnan I, Qureshi, Jonathan, Rosand, Joshua N, Goldstein

Publikováno v: Neurocritical care. 32(1)

It is not clear whether subsets of patients with intracerebral hemorrhage (ICH) benefit from intensive blood pressure (BP) lowering. We evaluated whether white matter hyperintensities (WMH) burden influences response to this therapy.Retrospective sec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::62ec8637fa0c187efb9d3f3f150acf87
https://pubmed.ncbi.nlm.nih.gov/31218636

Mixed-location cerebral hemorrhage/microbleeds: Underlying microangiopathy and recurrence risk

Autor: Eitan Auriel, Steven M. Greenberg, Leonardo Pantoni, Marco Pasi, Jonathan Rosand, Gregoire Boulouis, Anand Viswanathan, M. Edip Gurol, Alison Ayres, Kristin Schwab, Andreas Charidimou, Joshua N. Goldstein

Publikováno v: Neurology. 90(2)

ObjectiveTo assess the predominant type of cerebral small vessel disease (SVD) and recurrence risk in patients who present with a combination of lobar and deep intracerebral hemorrhage (ICH)/microbleed locations (mixed ICH).MethodsOf 391 consecutive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525fb09f624ad6aebe98be924a38e21e
https://pubmed.ncbi.nlm.nih.gov/29247077

Abstract 85: Small Vessel Disease and Stroke During Sleep

Autor: Arne Lauer, Hakan Ay, Andreas Charidimou, Matt Bianchi, Alison Ayres, Kristin Schwab, Anand Viswanathan, Jonathan Rosand, Steven Greenberg, Edip M Gurol

Publikováno v: Stroke. 47

Introduction/Hypothesis: Stroke onset during sleep is common and sleep related pathologies have been associated with increased stroke risk. Based on available preliminary data, we tested the hypothesis that stroke during sleep is associated with smal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f6b61c197a88f5089bc236ca05683984
https://doi.org/10.1161/str.47.suppl_1.85

Abstract WP174: Prestroke Selective Serotonin Reuptake Inhibitor Use and Functional Outcomes in Ischemic Stroke

Autor: Mark Etherton, Khawja A Siddiqui, Alison Ayres, Lee H Schwamm

Publikováno v: Stroke. 47

Introduction: Selective serotonin reuptake inhibitors (SSRIs) have been implicated in contributing to recovery after acute ischemic stroke. In particular, post stroke initiation of an SSRI has been demonstrated to improve motor recovery. The role of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d72ea1c61c18b99c93b54743043117b7
https://doi.org/10.1161/str.47.suppl_1.wp174