Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alison A. Beharka"'
Autor:
Simin Nikbin Meydan, Alison A. Beharka
Publikováno v:
Nutrition Reviews. 56:S49-S58
Autor:
Cecilia D. Gaynor, Alison A. Beharka, Larry S. Schlesinger, Francis X. McCormack, Dennis R. Voelker, Byoung K. Kang
Publikováno v:
The Journal of Immunology. 169:3565-3573
Inhaled particulates and microbes are continually cleared by a complex array of lung innate immune determinants, including alveolar macrophages (AMs). AMs are unique cells with an enhanced capacity for phagocytosis that is due, in part, to increased
Autor:
Alison A. Beharka, Simin Nikbin Meydani, Mariana Nikolova-Karakashian, Helen J. Palmer, K. Eric Paulson, Dayong Wu, Kate J. Claycombe
Publikováno v:
Journal of Biological Chemistry. 277:30784-30791
Previously, we showed that macrophages (MØ) from old mice have significantly higher levels of lipopolysaccharide (LPS)-induced prostaglandin E(2) (PGE(2)) production than young mice, due to increased cyclooxygenase-2 (COX-2) mRNA levels. The aim of
Publikováno v:
Free Radical Biology and Medicine. 32:503-511
Vitamin E inhibits cyclooxygenase activity in macrophages from old mice by reducing peroxynitrite production. PGE(2) is a proinflammatory mediator that has been linked to a variety of age-associated diseases such as cancer, arthritis, and cardiovascu
Autor:
Sung Nim Han, Dayong Wu, D.E. Smith, Bradley S. Bender, W K Ha, Simin Nikbin Meydani, Alison A. Beharka
Publikováno v:
Immunology. 100:487-493
Compared with young mice, old mice infected with influenza virus have significantly higher pulmonary viral titres, although these can be reduced significantly with dietary vitamin E supplementation. T helper 1 (Th1) cytokines, especially interferon-g
Autor:
Guohua Cao, Ruth D. Lipman, D.E. Smith, Alison A. Beharka, Sung Nim Han, Mohsen Meydani, Simin Nikbin Meydani, Dayong Wu, Oskar Adolfsson
Publikováno v:
Nutrition Research. 20:281-296
Although macrophage (Mo)-derived compounds, including proinflammatory cytokines, prostaglandins (PG), and nitric oxide (NO), play important roles in host defense, excessive or inappropriate production of them has been implicated in the pathogenesis o
Autor:
Ruth D. Lipman, Keith R Martin, Roderick E. Bronson, Alison A. Beharka, Simin Nikbin Meydani, D.E. Smith, Mohsen Meydani, Dayong Wu, Guohua Cao, Sung Nim Han
Publikováno v:
Annals of the New York Academy of Sciences. 854:352-360
The impact of diet and specific food groups on aging and age-associated degenerative diseases has been widely recognized in recent years. The modern concept of the free radical theory of aging takes as its basis a shift in the antioxidant/prooxidant
Autor:
Simin Nikbin Meydani, Sung Nim Han, Dayong Wu, Casilda V. Mura, Alison A. Beharka, Daniel H. Hwang, K. Eric Paulson
Publikováno v:
American Journal of Physiology-Cell Physiology. 275:C661-C668
We previously showed that increased macrophage and PGE2production with age is due to enhanced cyclooxygenase (COX) activity and COX-2 expression. This study determined the effect of vitamin E supplementation on macrophage PGE2synthesis in young and o
Publikováno v:
The American Journal of Clinical Nutrition. 68:164-170
We showed previously that natural killer (NK) cell activity is significantly greater in elderly men supplemented with b-carotene than in those taking placebo. In an attempt to determine the mechanism of b-carotene's effect, we analyzed the production
Autor:
Alison A. Beharka, Stephen K. Chapes
Publikováno v:
Journal of Leukocyte Biology. 63:297-304
We examined the pathogenesis of the facultative intracellular bacterium, Salmonella typhimurium in MHCII-/-, C2D knock-out mice, and wild-type C57BL/6J mice. The MHCII knock-out shortened the kinetics of animal death and reduced the dose of S. typhim