Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Alison, Maloney"'
Autor:
Daniel J. Lightwood, Rebecca J. Munro, John Porter, David McMillan, Bruce Carrington, Alison Turner, Anthony Scott-Tucker, Elizabeth S. Hickford, Antje Schmidt, David Fox, Alison Maloney, Tom Ceska, Tim Bourne, James O’Connell, Alastair D. G. Lawson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
TNF can be inhibited by small molecules that stabilize the TNF trimer in an asymmetric conformation. Here, the authors develop a monoclonal antibody that selectively binds this inactive form of TNF, enabling both target engagement assessment and stru
Externí odkaz:
https://doaj.org/article/a700e6f6d0e341fa8bbbdf0203d53866
Autor:
James O’Connell, John Porter, Boris Kroeplien, Tim Norman, Stephen Rapecki, Rachel Davis, David McMillan, Tracy Arakaki, Alex Burgin, David Fox III, Tom Ceska, Fabien Lecomte, Alison Maloney, Alex Vugler, Bruce Carrington, Benjamin P Cossins, Tim Bourne, Alastair Lawson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
While biologics have been successfully applied in TNF antagonist treatments, there are no clinically approved small molecules that target TNF. Here, the authors discover potent small molecule inhibitors of TNF, elucidate their molecular mechanism, an
Externí odkaz:
https://doaj.org/article/cd8aea08c83948d3a69fc5302494dedc
Autor:
Elizabeth S Hickford, James O'Connell, Alison Maloney, Peter Florian, Geoffrey I Johnston, Chiara Carla Rospo, Matthias Herrmann, Sara Wright, Tim Bourne
Publikováno v:
Bioanalysis. 15:343-359
Background: An antibody specific to small-molecule inhibitor-bound TNF has enabled the development of target occupancy biomarker assays to support the development of novel treatments for autoimmune disorders. Materials & methods: ELISAs were develope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8fcae5a6bab11622857b928b40ee7d4b
https://doi.org/10.4155/bio-2022-0231
https://doi.org/10.4155/bio-2022-0231
Autor:
Bethan L. Thomas, Suzanne E. Eldridge, Babak Nosrati, Mario Alvarez, Anne‐Sophie Thorup, Giovanna Nalesso, Sara Caxaria, Aida Barawi, James G. Nicholson, Mauro Perretti, Carles Gaston‐Massuet, Costantino Pitzalis, Alison Maloney, Adrian Moore, Ray Jupp, Francesco Dell'Accio
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 7, Pp n/a-n/a (2021)
Abstract Cartilage defects repair poorly. Recent genetic studies suggest that WNT3a may contribute to cartilage regeneration, however the dense, avascular cartilage extracellular matrix limits its penetration and signalling to chondrocytes. Extracell
Externí odkaz:
https://doaj.org/article/1e6db36139a04cbf8ffe4756c472fec6
Autor:
Paul Workman, Edward McDonald, Wynne Aherne, Sue Eccles, Laurence Pearl, Richard Marais, Florence Raynaud, Angela Hayes, Karen Ball, Kwai-Ming J. Cheung, Thomas P. Matthews, Lisa Patterson, Sharon Sanderson, Gary Box, Paul A. Clarke, Marissa Powers, Alison Maloney, S. Mark Roe, Chrisostomos Prodromou, Martin Rowlands, Kathy Boxall, Swee Y. Sharp
Supplementary Materials, Table 1 and Figures 1-3 from In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3067455caa50cedcd39bdbcf66eeee
https://doi.org/10.1158/0008-5472.22368564
https://doi.org/10.1158/0008-5472.22368564
Autor:
Paul Workman, Michael Waterfield, Al Burlingame, Michael Walton, Joanne Salmons, Emmanuel deBilly, Marissa Powers, Swee Sharp, Ian Judson, Udai Banerji, Wynne Aherne, Lindsay Stimson, Rainer Cramer, Marketa Zvelebil, Alice Yang, Akunna Akpan, Jens-Oliver Koopman, Rob Stein, Soren Naaby-Hansen, Paul A. Clarke, Alison Maloney
Supplementary Data URL from Gene and Protein Expression Profiling of Human Ovarian Cancer Cells Treated with the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb4b4ebae9087b2c2c46e29324919a96
https://doi.org/10.1158/0008-5472.22368576.v1
https://doi.org/10.1158/0008-5472.22368576.v1
Autor:
Paul Workman, Michael Waterfield, Al Burlingame, Michael Walton, Joanne Salmons, Emmanuel deBilly, Marissa Powers, Swee Sharp, Ian Judson, Udai Banerji, Wynne Aherne, Lindsay Stimson, Rainer Cramer, Marketa Zvelebil, Alice Yang, Akunna Akpan, Jens-Oliver Koopman, Rob Stein, Soren Naaby-Hansen, Paul A. Clarke, Alison Maloney
Supplementary Figure 1 from Gene and Protein Expression Profiling of Human Ovarian Cancer Cells Treated with the Heat Shock Protein 90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1456e7090b27bfeb595dd22afa87203f
https://doi.org/10.1158/0008-5472.22368573
https://doi.org/10.1158/0008-5472.22368573
Autor:
Paul Workman, Edward McDonald, Wynne Aherne, Sue Eccles, Laurence Pearl, Richard Marais, Florence Raynaud, Angela Hayes, Karen Ball, Kwai-Ming J. Cheung, Thomas P. Matthews, Lisa Patterson, Sharon Sanderson, Gary Box, Paul A. Clarke, Marissa Powers, Alison Maloney, S. Mark Roe, Chrisostomos Prodromou, Martin Rowlands, Kathy Boxall, Swee Y. Sharp
The molecular chaperone heat shock protein 90 (HSP90) has emerged as an exciting molecular target. Derivatives of the natural product geldanamycin, such as 17-allylamino-17-demethoxy-geldanamycin (17-AAG), were the first HSP90 ATPase inhibitors to en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1541e1c805f7ce1cf638b201ed10da6e
https://doi.org/10.1158/0008-5472.c.6496002.v1
https://doi.org/10.1158/0008-5472.c.6496002.v1
Autor:
Paul Workman, Michael Waterfield, Al Burlingame, Michael Walton, Joanne Salmons, Emmanuel deBilly, Marissa Powers, Swee Sharp, Ian Judson, Udai Banerji, Wynne Aherne, Lindsay Stimson, Rainer Cramer, Marketa Zvelebil, Alice Yang, Akunna Akpan, Jens-Oliver Koopman, Rob Stein, Soren Naaby-Hansen, Paul A. Clarke, Alison Maloney
The promising antitumor activity of 17-allylamino-17-demethoxygeldanamycin (17AAG) results from inhibition of the molecular chaperone heat shock protein 90 (HSP90) and subsequent degradation of multiple oncogenic client proteins. Gene expression micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e8d9964da35d5835cf227d7436ec80
https://doi.org/10.1158/0008-5472.c.6496011.v1
https://doi.org/10.1158/0008-5472.c.6496011.v1
Publikováno v:
International Journal of Technology Assessment in Health Care. 35:384-392
ObjectivesThis study's intent was to determine if a qualitative benefit risk framework could be used or modified to further enable Health Technology Reassessment (HTR) of prescription medicine recommendations. The purpose of this research was to unde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fbc07d418b5022e7dd3efb80e90733c
https://doi.org/10.1017/s026646231900062x
https://doi.org/10.1017/s026646231900062x