Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Alison, Finnegan"'
Autor:
Margaret Veselits, Azusa Tanaka, Stanley Lipkowitz, Shannon O'Neill, Roger Sciammas, Alison Finnegan, Jian Zhang, Marcus R Clark
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e89792 (2014)
Casitas B-lineage lymphoma-b (Cbl-b) is a ubiquitin ligase (E3) that modulates signaling by tagging molecules for degradation. It is a complex protein with multiple domains and binding partners that are not involved in ubiquitinating substrates. Here
Externí odkaz:
https://doaj.org/article/0c08a800468f46e6b666ed36631589c0
Autor:
Amanda L. Marzo, Eliseo F. Castillo, Yanxia Cao, Zurisaday Quiles, Ryan T. Sowell, Magdalena Rogozinska, Alison Finnegan, Josef W. Goldufsky
Publikováno v:
The Journal of Immunology. 199:2536-2546
IL-15 is an essential cytokine known to promote T cell survival and activate the effector function of memory phenotype CD8 T cells. Blocking IL-15 signals also significantly impacts tissue-specific effector and memory CD8 T cell formation. In this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc2c6d46b4fd6b1d1dce06ae6de0f803
https://doi.org/10.4049/jimmunol.1501638
https://doi.org/10.4049/jimmunol.1501638
Autor:
Harold L. Steiner, Daniel H. Zimmerman, Roy E. Carambula, Tibor T. Glant, Katalin Mikecz, Alison Finnegan, Ken S. Rosenthal
Publikováno v:
Expert Review of Vaccines. 14:891-908
The current status of therapeutic vaccines for autoimmune diseases is reviewed with rheumatoid arthritis as the focus. Therapeutic vaccines for autoimmune diseases must regulate or subdue responses to common self-antigens. Ideally, such a vaccine wou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f19f2a9dd6a826ce7bcc5f6bfe074e6
https://doi.org/10.1586/14760584.2015.1026330
https://doi.org/10.1586/14760584.2015.1026330
Publikováno v:
Arthritis & Rheumatology. 66:60-67
Objective Inducible costimulator (ICOS)–ICOSL interactions are necessary for activation of Teff cells and follicular helper T (Tfh) cells. ICOSL is expressed on B cells, macrophages, and dendritic cells and can be induced on nonhematopoietic cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::549448900855ec3e0f007305600a4f70
https://doi.org/10.1002/art.38207
https://doi.org/10.1002/art.38207
Autor:
Anjali Nair, Charles A. Bush-Joseph, Carla R. Scanzello, Veero Kanda, Anne-Marie Malfait, Nikhil N. Verma, Mary K. Crow, Alison Finnegan, Susan Chubinskaya, Katalin Mikecz, G T Spear, Tibor T. Glant
Publikováno v:
Arthritis & Rheumatism. 64:2268-2277
Synovial inflammation, a feature of both osteoarthritis (OA) and meniscal injury, is hypothesized to be triggered in part via stimulation of Toll-like receptors (TLRs). We undertook this study to test whether a TLR-2- or TLR-4-stimulating factor in s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b05551162957132356046fa2a7835cf
https://doi.org/10.1002/art.34495
https://doi.org/10.1002/art.34495
Autor:
Joel A. Block, Lewis Fogg, Alison Finnegan, Anna Plaas, Rediet Kokebie, Rachel A. Mikolaitis, Winston Sequeira, Rohit Aggarwal, Meenakshi Jolly
Publikováno v:
Arthritis Care & Research. 63:891-898
Objective To evaluate serum free light chains (FLC) as a putative biomarker of systemic lupus erythematosus (SLE) activity. Methods Seventy-five SLE patients and 41 age- and sex-matched rheumatoid arthritis (RA) controls were enrolled. Disease activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82d8668aa717160ffd4a9c7d1a57985
https://doi.org/10.1002/acr.20446
https://doi.org/10.1002/acr.20446
Autor:
Katalin Olasz, Anna Laszlo, Katalin Mikecz, Ferenc Boldizsár, Akos Hegyi, Alison Finnegan, Gyorgy Nagyeri, Tibor T. Glant, Marianna Radacs
Publikováno v:
Arthritis & Rheumatism. 63:1312-1321
Objective To develop a simplified and relatively inexpensive version of cartilage proteoglycan–induced arthritis (PGIA), an autoimmunity model of rheumatoid arthritis (RA), and to evaluate the extent to which this new model replicates the disease p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dd02c98f9fa86d4efe98850d88e6eab
https://doi.org/10.1002/art.30261
https://doi.org/10.1002/art.30261
Autor:
Tamás Kobezda, Yumei Wang, Yanxia Cao, Alison Finnegan, Rachel Rodeghero, Lieping Chen, Keith M. Hamel
Publikováno v:
European Journal of Immunology. 40:3117-3127
The immune system has developed several regulatory mechanisms to maintain homeostasis of adaptive immune responses. T-cell programmed death (PD)-1 recognition of B7-H1 (PD-L1) expressed on APC and non-lymphoid tissue regulates T-cell activation. We s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ad74c05afc0a6a0f1912077891dc617
https://doi.org/10.1002/eji.201040690
https://doi.org/10.1002/eji.201040690
Autor:
Alison Finnegan, Keith M. Hamel, Katalin Mikecz, Tibor T. Glant, Paul D. Doodes, Yoichiro Iwakura, Yumei Wang, Yanxia Cao, Rachel Rodeghero
Publikováno v:
The Journal of Immunology. 184:1552-1559
The contribution of the proinflammatory cytokines IFN-gamma and IL-17 to the pathogenesis of experimental arthritis is controversial. In proteoglycan (PG)-induced arthritis (PGIA), severe arthritis is dependent on the production of IFN-gamma, whereas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7644805af9490effd4421f613e78a15c
https://doi.org/10.4049/jimmunol.0902907
https://doi.org/10.4049/jimmunol.0902907
Publikováno v:
AIDS Research and Human Retroviruses. 25:1157-1164
The goal of this study was to develop an in vivo murine model that can be used to study the influence of HSV-2 on HIV infection. Mice expressing transgenes for human CD4, CCR5, and Cyclin T1 were infected intravaginally with HSV-2 and 3–7 days late
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c60a077fb114eb476cc57964bac4b044
https://doi.org/10.1089/aid.2009.0035
https://doi.org/10.1089/aid.2009.0035