Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Alison, Falconer"'
Autor:
Amarnath Challapalli, Tara D. Barwick, Suraiya R. Dubash, Marianna Inglese, Matthew Grech-Sollars, Kasia Kozlowski, Henry Tam, Neva H. Patel, Mathias Winkler, Penny Flohr, Azeem Saleem, Amit Bahl, Alison Falconer, Johann S. De Bono, Eric O. Aboagye, Stephen Mangar
Publikováno v:
Molecules, Vol 28, Iss 24, p 8018 (2023)
Malignant transformation is characterised by aberrant phospholipid metabolism of cancers, associated with the upregulation of choline kinase alpha (CHKα). Due to the metabolic instability of choline radiotracers and the increasing use of late-imagin
Externí odkaz:
https://doaj.org/article/74674289d27f44588c3184f2bea4b18b
Autor:
Martin J. Connor, Mesfin G. Genie, David Burns, Edward J. Bass, Michael Gonzalez, Naveed Sarwar, Alison Falconer, Stephen Mangar, Tim Dudderidge, Vincent Khoo, Mathias Winkler, Hashim U. Ahmed, Verity Watson
Publikováno v:
European Urology Open Science, Vol 36, Iss , Pp 9-18 (2022)
Context: Advances in systemic agents have increased overall survival for men diagnosed with metastatic prostate cancer. Additional cytoreductive prostate treatments and metastasis-directed therapies are under evaluation. These confer toxicity but may
Externí odkaz:
https://doaj.org/article/c5858afe4257417b8ca022687f6a4f2d
Autor:
Martin John Connor, Johanna Sukumar, Naveed Sarwar, Michael Gonzalez, Alison Falconer, Natalia Klimowska-Nassar, Kamalram Thippu Jayaprakash, Dolan Basak, Gail Horan, Bhavan Rai, Stephen Mangar, Vincent Khoo, Tim Dudderidge, Mathias Winkler, Hashim Uddin Ahmed, Mesfin G Genie, Verity Watson, Tzveta Pokrovska, Feargus Hosking-Jervis, Angus Robinson, Mark Beresford
Publikováno v:
BMJ Open, Vol 11, Iss 11 (2021)
Introduction Systemic therapy with androgen deprivation therapy (ADT) and intensification with agents such as docetaxel, abiraterone acetate and enzalutamide has resulted in improved overall survival in men with de novo synchronous metastatic hormone
Externí odkaz:
https://doaj.org/article/a235c0be59294643acac82c308b7dc0a
Autor:
Gerhardt Attard, Laura Murphy, Noel W Clarke, Ashwin Sachdeva, Craig Jones, Alex Hoyle, William Cross, Robert J Jones, Christopher C Parker, Silke Gillessen, Adrian Cook, Chris Brawley, Clare Gilson, Hannah Rush, Hoda Abdel-Aty, Claire L Amos, Claire Murphy, Simon Chowdhury, Zafar Malik, J Martin Russell, Nazia Parkar, Cheryl Pugh, Carlos Diaz-Montana, Carmel Pezaro, Warren Grant, Helen Saxby, Ian Pedley, Joe M O'Sullivan, Alison Birtle, Joanna Gale, Narayanan Srihari, Carys Thomas, Jacob Tanguay, John Wagstaff, Prantik Das, Emma Gray, Mymoona Alzouebi, Omi Parikh, Angus Robinson, Amir H Montazeri, James Wylie, Anjali Zarkar, Richard Cathomas, Michael D Brown, Yatin Jain, David P Dearnaley, Malcolm D Mason, Duncan Gilbert, Ruth E Langley, Robin Millman, David Matheson, Matthew R Sydes, Louise C Brown, Mahesh K B Parmar, Nicholas D James, Elin Jones, Katherine Hyde, Hilary Glen, Sarah Needleman, Ursula McGovern, Denise Sheehan, Sangeeta Paisey, Richard Shaffer, Mark Beresford, Emilio Porfiri, David Fackrell, Ling Lee, Thiagarajan Sreenivasan, Sue Brock, Simon Brown, Amit Bahl, Mike Smith-Howell, Cathryn Woodward, Mau-Don Phan, Danish Mazhar, Krishna Narahari, Fiona Douglas, Anil Kumar, Abdel Hamid, Azman Ibrahim, Dakshinamoorthy Muthukumar, Matthew Simms, Jane Worlding, Anna Tran, Mohammed Kagzi, Virgil Sivoglo, Benjamin Masters, Pek Keng-Koh, Caroline Manetta, Duncan McLaren, Nishi Gupta, Stergios Boussios, Henry Taylor, John Graham, Carla Perna, Lucinda Melcher, Ami Sabharwal, Uschi Hofmann, Robert Dealey, Neil McPhail, Robert Brierly, Lisa Capaldi, Norma Sidek, Peter Whelan, Peter Robson, Alison Falconer, Sarah Rudman, Sindu Vivekanandan, Vinod Mullessey, Maria Vilarino-Varela, Vincent Khoo, Karen Tipples, Mehran Afshar, Patryk Brulinski, Vijay Sangar, Clive Peedell, Ashraf Azzabi, Peter Hoskin, Viwod Mullassery, Santhanam Sundar, Yakhub Khan, Ruth Conroy, Andrew Protheroe, Judith Carser, Paul Rogers, Kathryn Tarver, Stephanie Gibbs, Mohammad Muneeb Khan, Mohan Hingorani, Simon Crabb, Manal Alameddine, Neeraj Bhalla, Robert Hughes, John Logue, Darren Leaning, Salil Vengalil, Daniel Ford, Georgina Walker, Ahmed Shaheen, Omar Khan, Andrew Chan, Imtiaz Ahmed, Serena Hilman, Ian Sayers, Ashok Nikapota, David Bloomfield, Tim Porter, Joji Joseph, Cyrill Rentsch, Ricardo Pereira Mestre, Enrico Roggero, Jörg Beyer, Markus Borner, Raeto Strebel, Dominik Berthold, Daniel Engeler, Hubert John, Razvan Popescu, Donat Durr
Publikováno v:
STAMPEDE investigators, Attard, G, Murphy, L, Clarke, N W, Sachdeva, A, Jones, C, Hoyle, A, Cross, W, Jones, R J, Parker, C C, Gillessen, S, Cook, A, Brawley, C, Gilson, C, Rush, H, Abdel-Aty, H, Amos, C L, Murphy, C, Chowdhury, S, Malik, Z, Russell, J M, Parkar, N, Pugh, C, Diaz-Montana, C, Pezaro, C, Grant, W, Saxby, H, Pedley, I, O'Sullivan, J M, Birtle, A, Gale, J, Srihari, N, Thomas, C, Tanguay, J, Wagstaff, J, Das, P, Gray, E, Alzouebi, M, Parikh, O, Robinson, A, Montazeri, A H, Wylie, J, Zarkar, A, Cathomas, R, Brown, M D, Jain, Y, Dearnaley, D P, Mason, M D, Gilbert, D, Langley, R E & Millman, R 2023, ' Abiraterone acetate plus prednisolone with or without enzalutamide for patients with metastatic prostate cancer starting androgen deprivation therapy: final results from two randomised phase 3 trials of the STAMPEDE platform protocol ', Lancet Oncology, vol. 24, no. 5, pp. 443-456 . https://doi.org/10.1016/S1470-2045(23)00148-1
Attard, G, Murphy, L, Clarke, N W, Sachdeva, A, Jones, C, Hoyle, A, Cross, W, Jones, R J, Parker, C C, Gillessen, S, Cook, A, Brawley, C, Gilson, C, Rush, H, Abdel-Aty, H, Amos, C L, Murphy, C, Chowdhury, S, Malik, Z, Russell, J M, Parkar, N, Pugh, C, Diaz-Montana, C, Pezaro, C, Grant, W, Saxby, H, Pedley, I, O'Sullivan, J M, Birtle, A, Gale, J, Srihari, N, Thomas, C, Tanguay, J, Wagstaff, J, Das, P, Gray, E, Alzouebi, M, Parikh, O, Robinson, A, Montazeri, A H, Wylie, J, Zarkar, A, Cathomas, R, Brown, M D, Jain, Y, Dearnaley, D P, Mason, M D, Gilbert, D, Langley, R E & Millman, R 2023, ' Abiraterone acetate plus prednisolone with or without enzalutamide for patients with metastatic prostate cancer starting androgen deprivation therapy : final results from two randomised phase 3 trials of the STAMPEDE platform protocol ', The Lancet. Oncology, vol. 24, no. 5, pp. 443-456 . https://doi.org/10.1016/S1470-2045(23)00148-1
Attard, G, Murphy, L, Clarke, N W, Sachdeva, A, Jones, C, Hoyle, A, Cross, W, Jones, R J, Parker, C C, Gillessen, S, Cook, A, Brawley, C, Gilson, C, Rush, H, Abdel-Aty, H, Amos, C L, Murphy, C, Chowdhury, S, Malik, Z, Russell, J M, Parkar, N, Pugh, C, Diaz-Montana, C, Pezaro, C, Grant, W, Saxby, H, Pedley, I, O'Sullivan, J M, Birtle, A, Gale, J, Srihari, N, Thomas, C, Tanguay, J, Wagstaff, J, Das, P, Gray, E, Alzouebi, M, Parikh, O, Robinson, A, Montazeri, A H, Wylie, J, Zarkar, A, Cathomas, R, Brown, M D, Jain, Y, Dearnaley, D P, Mason, M D, Gilbert, D, Langley, R E & Millman, R 2023, ' Abiraterone acetate plus prednisolone with or without enzalutamide for patients with metastatic prostate cancer starting androgen deprivation therapy : final results from two randomised phase 3 trials of the STAMPEDE platform protocol ', The Lancet. Oncology, vol. 24, no. 5, pp. 443-456 . https://doi.org/10.1016/S1470-2045(23)00148-1
Background: Abiraterone acetate plus prednisolone (herein referred to as abiraterone) or enzalutamide added at the start of androgen deprivation therapy improves outcomes for patients with metastatic prostate cancer. Here, we aimed to evaluate long-t
Autor:
Francesca Fiorentino, Iqbal Shergill, Manal Kumar, Martin John Connor, Taimur Tariq Shah, Katarzyna Smigielska, Emily Day, Johanna Sukumar, Naveed Sarwar, Michael Gonzalez, Alison Falconer, Natalia Klimowska-Nassar, Martin Evans, Olivia Frances Naismith, Kamalram Thippu Jayaprakash, Derek Price, Shiva Gayadeen, Dolan Basak, Gail Horan, Denise Sheehan, Azman Ibrahim, Cathryn Brock, Rachel A. Pearson, Nicola Anyamene, Catherine Heath, Bhavan Rai, Giles Hellawell, Stuart McCracken, Bijan Khoubehi, Stephen Mangar, Vincent Khoo, Tim Dudderidge, John Nicholas Staffurth, Mathias Winkler, Hashim Uddin Ahmed
Publikováno v:
BMJ Open, Vol 11, Iss 2 (2021)
Introduction Survival in men diagnosed with de novo synchronous metastatic prostate cancer has increased following the use of upfront systemic treatment, using chemotherapy and other novel androgen receptor targeted agents, in addition to standard an
Externí odkaz:
https://doaj.org/article/5990ac2cc8ae4ff48516b35753c3f048
Autor:
Colin S. Cooper, Ian Judson, Cyril Fisher, J. Meirion Thomas, D. Chas Mangham, Robert J. Grimer, Janet Shipley, Rubin Wang, Toby Roe, Penny Flohr, Jeremy Clark, Sandra Edwards, Alison Falconer, Megan John, Yin-Fai Lee
Supplementary Figure 1 from A Gene Expression Signature Associated with Metastatic Outcome in Human Leiomyosarcomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6944ad100d94d8cf57373b987582f2b9
https://doi.org/10.1158/0008-5472.22363353
https://doi.org/10.1158/0008-5472.22363353
Autor:
Colin S. Cooper, Ian Judson, Cyril Fisher, J. Meirion Thomas, D. Chas Mangham, Robert J. Grimer, Janet Shipley, Rubin Wang, Toby Roe, Penny Flohr, Jeremy Clark, Sandra Edwards, Alison Falconer, Megan John, Yin-Fai Lee
Supplementary Tables 2 and 3 from A Gene Expression Signature Associated with Metastatic Outcome in Human Leiomyosarcomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9a49e2c17c66804b55a439feb7fa85
https://doi.org/10.1158/0008-5472.22363347
https://doi.org/10.1158/0008-5472.22363347
Autor:
Colin S. Cooper, Ian Judson, Cyril Fisher, J. Meirion Thomas, D. Chas Mangham, Robert J. Grimer, Janet Shipley, Rubin Wang, Toby Roe, Penny Flohr, Jeremy Clark, Sandra Edwards, Alison Falconer, Megan John, Yin-Fai Lee
Supplementary Table 1 from A Gene Expression Signature Associated with Metastatic Outcome in Human Leiomyosarcomas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::084c4048afa1d81b8717076cde1e9725
https://doi.org/10.1158/0008-5472.22363350.v1
https://doi.org/10.1158/0008-5472.22363350.v1
Autor:
Colin S. Cooper, Ian Judson, Cyril Fisher, J. Meirion Thomas, D. Chas Mangham, Robert J. Grimer, Janet Shipley, Rubin Wang, Toby Roe, Penny Flohr, Jeremy Clark, Sandra Edwards, Alison Falconer, Megan John, Yin-Fai Lee
Metastasis is a major factor associated with poor prognosis in cancer, but little is known of its molecular mechanisms. Although the clinical behavior of soft tissue sarcomas is highly variable, few reliable determinants of outcome have been identifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7de05b616532059edccef099fd84a182
https://doi.org/10.1158/0008-5472.c.6493665
https://doi.org/10.1158/0008-5472.c.6493665
Autor:
Deepika Reddy, Raj Persad, Manit Arya, R. Hindley, Mark Emberton, Raj Nigam, M. Winkler, Jochem R. N. van der Voort van Zyp, Hashim U. Ahmed, A. Emara, Clement Orczyk, Caroline M. Moore, Taimur T. Shah, Tim Dudderidge, Stephen Robinson, Stephen Mangar, Feargus Hosking-Jervis, Marieke J. van Son, Stuart McCracken, Alison Falconer, Jaspal Virdi, Henry Lewi, Jan J. W. Lagendijk, Max Peters
Publikováno v:
Prostate Cancer and Prostatic Diseases. 24:1120-1128
For localised prostate cancer, focal therapy offers an organ-sparing alternative to radical treatments (radiotherapy or prostatectomy). Currently, there is no randomised comparative effectiveness data evaluating cancer control of both strategies. Fol