Výsledky vyhledávání - "Alison, Bendele"

Akademický článek

Viscosupplementation may preserve tibial cartilage and collagen in osteoarthritis: findings from a preclinical model of osteoarthritis

Autor: John Lokhnauth, Kevin E. Driscoll, Alison Bendele, Faizan Niazi, Alfred Liang, Crilles C. Larsen

Publikováno v: Journal of Experimental Orthopaedics, Vol 7, Iss 1, Pp 1-11 (2020)

Abstract Purpose Intraarticular (IA) hyaluronic acid (HA) injection is used to reduce pain and improve mobility in knee osteoarthritis (OA). Little is known about histopathological changes underlying HA efficacy. This study investigated dose-related

Externí odkaz: https://doaj.org/article/4dbf1cf1d9314118b7ed3ebb072c477f

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Viscosupplementation may preserve tibial cartilage and collagen in osteoarthritis: findings from a preclinical model of osteoarthritis

Autor: Crilles Casper Larsen, Kevin E. Driscoll, Alison Bendele, Alfred Chi-Yeh Liang, John Lokhnauth, Faizan Niazi

Publikováno v: Journal of Experimental Orthopaedics, Vol 7, Iss 1, Pp 1-11 (2020)
Journal of Experimental Orthopaedics

Purpose Intraarticular (IA) hyaluronic acid (HA) injection is used to reduce pain and improve mobility in knee osteoarthritis (OA). Little is known about histopathological changes underlying HA efficacy. This study investigated dose-related effects o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1919382ff57de89fd70137d7b8b6a9
http://link.springer.com/article/10.1186/s40634-020-00256-4

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Akademický článek

Neurostimulation of the cholinergic anti-inflammatory pathway ameliorates disease in rat collagen-induced arthritis.

Autor: Yaakov A Levine, Frieda A Koopman, Michael Faltys, April Caravaca, Alison Bendele, Ralph Zitnik, Margriet J Vervoordeldonk, Paul Peter Tak

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e104530 (2014)

The inflammatory reflex is a physiological mechanism through which the nervous system maintains immunologic homeostasis by modulating innate and adaptive immunity. We postulated that the reflex might be harnessed therapeutically to reduce pathologica

Externí odkaz: https://doaj.org/article/f0dbe7fdd1be435e9848ec2bb20e1423

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Human blood-based anti-inflammatory solution inhibits osteoarthritis progression in a meniscal-tear rat study

Autor: Taylor Marohl, Alison Bendele, Jennifer E. Woodell-May, William P. King

Publikováno v: Journal of Orthopaedic Research. 35:2260-2268

Current osteoarthritis (OA) research searches for treatments that modify the course of disease progression. Autologous Protein Solution (APS) is derived from whole blood and is a unique autologous therapy that contains high concentrations of white bl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d9b341e18c2a284dcd78bb0853a6431
https://doi.org/10.1002/jor.23528

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RVX-297, a BET Bromodomain Inhibitor, Has Therapeutic Effects in Preclinical Models of Acute Inflammation and Autoimmune Disease

Autor: Alison Bendele, Narmada Shenoy, Suzana Marusic, Raymond Yu, Gregory S. Wagner, Ravi Jahagirdar, Karen Norek, Dean Gilham, Jennifer Tobin, Kevin G. McLure, Henrik C. Hansen, Ewelina Kulikowski, Peter Young, Sarah Attwell, Norman C.W. Wong

Publikováno v: Molecular pharmacology. 92(6)

Bromodomain (BD) and extra-terminal domain containing proteins (BET) are chromatin adapters that bind acetylated histone marks via two tandem BDs, BD1 and BD2, to regulate gene transcription. BET proteins are involved in transcriptional reprogramming

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13938f005c87ac17258bfce31797ed78
https://pubmed.ncbi.nlm.nih.gov/28974538

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Intra-articular (IA) Ropivacaine Microparticle Suspensions Reduce Pain, Inflammation, Cytokine, and Substance P Levels Significantly More than Oral or IA Celecoxib in a Rat Model of Arthritis

Autor: Alison Bendele, Roy Bogseth, Jerome H. Gass, Paul W. Valaitis, Sabine Graham, Audrey M. Hutchcraft, Kelly Balla, Jane Werling, Barrett E. Rabinow

Publikováno v: Inflammation. 38:40-60

Current therapeutic treatment options for osteoarthritis entail significant safety concerns. A novel ropivacaine crystalline microsuspension for bolus intra-articular (IA) delivery was thus developed and studied in a peptidoglycan polysaccharide (PGP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79bf3386ab37c65aa91216e8092d0037
https://doi.org/10.1007/s10753-014-0006-z

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Comparison of the effect of intra-tendon applications of recombinant human platelet-derived growth factor-BB, platelet-rich plasma, steroids in a rat achilles tendon collagenase model

Autor: Christopher K. Hee, Luis A. Solchaga, Joshua S. Dines, Alison Bendele, Vivek Shah, Leo B. Snel, Hans K. Kestler

Publikováno v: Journal of Orthopaedic Research. 32:145-150

This study compared the effect of intra-tendon (IT) delivery of recombinant human platelet-derived growth factor-BB (rhPDGF-BB), platelet-rich plasma (PRP) and corticosteroids in a rat tendinopathy model. Seven days after collagenase induction of ten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4a54ff0f564a89d3d254f5b7f30b75ad
https://doi.org/10.1002/jor.22483

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Human blood-based anti-inflammatory solution inhibits osteoarthritis progression in a meniscal-tear rat study

Autor: William, King, Alison, Bendele, Taylor, Marohl, Jennifer, Woodell-May

Publikováno v: Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 35(10)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3fc707cee56555abe3abac3f803a01b1
https://pubmed.ncbi.nlm.nih.gov/28139016

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