Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Alisha M Gruntman"'
Autor:
Motahareh Arjomandnejad, Katelyn Sylvia, Meghan Blackwood, Thomas Nixon, Qiushi Tang, Manish Muhuri, Alisha M. Gruntman, Guangping Gao, Terence R. Flotte, Allison M. Keeler
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 490-506 (2021)
Immune responses to adeno-associated virus (AAV) capsids limit the therapeutic potential of AAV gene therapy. Herein, we model clinical immune responses by generating AAV capsid-specific chimeric antigen receptor (AAV-CAR) T cells. We then modulate i
Externí odkaz:
https://doaj.org/article/1d3794b4a1154ad0b895efd390f57d2a
Autor:
Alisha M. Gruntman, Gwladys Gernoux, Qiushi Tang, Guo-Jie Ye, Dave R. Knop, Gensheng Wang, Janet Benson, Kristen E. Coleman, Allison M. Keeler, Christian Mueller, Louis G. Chicoine, Jeffrey D. Chulay, Terence R. Flotte
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 233-242 (2019)
Phase 1 and phase 2 gene therapy trials using intramuscular (IM) administration of a recombinant adeno-associated virus serotype 1 (rAAV1) for replacement of serum alpha-1 antitrypsin (AAT) deficiency have shown long-term (5-year) stable transgene ex
Externí odkaz:
https://doaj.org/article/ece0ba0412444a99888e9c8c1783ad84
Publikováno v:
Expert Opinion on Biological Therapy. 23:283-291
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f80121546f4ac57ab801e8f8fee166c7
https://doi.org/10.1080/14712598.2023.2183771
https://doi.org/10.1080/14712598.2023.2183771
Autor:
Thomas Nixon, Alisha M. Gruntman, Manish Muhuri, Katelyn Sylvia, Qiushi Tang, Meghan Blackwood, Motahareh Arjomandnejad, Terence R. Flotte, Guangping Gao, Allison M. Keeler
Publikováno v:
Molecular Therapy. Methods & Clinical Development
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 490-506 (2021)
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss, Pp 490-506 (2021)
Immune responses to adeno-associated virus (AAV) capsids limit the therapeutic potential of AAV gene therapy. Herein, we model clinical immune responses by generating AAV capsid-specific chimeric antigen receptor (AAV-CAR) T cells. We then modulate i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70860c21c999b963e59a951bdf35895
https://doi.org/10.1016/j.omtm.2021.10.010
https://doi.org/10.1016/j.omtm.2021.10.010
Autor:
Minwook Shin, Io Long Chan, Yuming Cao, Alisha M Gruntman, Jonathan Lee, Jacquelyn Sousa, Tomás C Rodríguez, Dimas Echeverria, Gitali Devi, Alexandre J Debacker, Michael P Moazami, Pranathi Meda Krishnamurthy, Julia M Rembetsy-Brown, Karen Kelly, Onur Yukselen, Elisa Donnard, Teagan J Parsons, Anastasia Khvorova, Erik J Sontheimer, René Maehr, Manuel Garber, Jonathan K Watts
Publikováno v:
Nucleic acids research. 50(15)
The lung is a complex organ with various cell types having distinct roles. Antisense oligonucleotides (ASOs) have been studied in the lung, but it has been challenging to determine their effectiveness in each cell type due to the lack of appropriate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fe664d47226164e85fab160012845d
https://pubmed.ncbi.nlm.nih.gov/35920332
https://pubmed.ncbi.nlm.nih.gov/35920332
Autor:
Denise Kelley, Jacob Michael Froehlich, Melissa R. Mazan, Mary Anna Labato, Trisha J. Oura, Alisha M. Gruntman, Claire E Dixon
Publikováno v:
Journal of Veterinary Emergency and Critical Care. 31:521-524
Objective To describe the use of therapeutic plasma exchange (TPE) in the treatment of flunixin meglumine overdose in a cria. Case summary A 3-day-old alpaca cria was diagnosed with ureteral obstruction and agenesis resulting in severe bilateral hydr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c74f111de0c10a989939a5f45f1323b
https://doi.org/10.1111/vec.13071
https://doi.org/10.1111/vec.13071
Autor:
Gwladys Gernoux, Marina Zieger, Terence R. Flotte, Christian Mueller, Alisha M. Gruntman, Meghan Blackwood
Publikováno v:
Molecular Therapy
With the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) approvals for Zolgensma, Luxturna, and Glybera, recombinant adeno-associated viruses (rAAVs) are considered efficient tools for gene transfer. However, studies in anim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e987d236ce1c220739cc6dee31e27fdb
http://europepmc.org/articles/PMC7054721
http://europepmc.org/articles/PMC7054721
Autor:
Qiushi Tang, Gensheng Wang, Christian Mueller, Gwladys Gernoux, Dave R. Knop, Louis G. Chicoine, Terence R. Flotte, Kristen E. Coleman, Allison M. Keeler, Alisha M. Gruntman, Guo-jie Ye, Janet M. Benson, Jeffrey D. Chulay
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 13, Iss, Pp 233-242 (2019)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Phase 1 and phase 2 gene therapy trials using intramuscular (IM) administration of a recombinant adeno-associated virus serotype 1 (rAAV1) for replacement of serum alpha-1 antitrypsin (AAT) deficiency have shown long-term (5-year) stable transgene ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95d4a2cb02817c18dc255b4bf3f9bb1
http://www.sciencedirect.com/science/article/pii/S2329050119300166
http://www.sciencedirect.com/science/article/pii/S2329050119300166
Autor:
Florie Borel, Weiying Li, Alisha M. Gruntman, Gabriella Oliveira, Mai K. ElMallah, Airiel M. Davis, Huaming Sun, Terence R. Flotte, Christian Mueller, Andrew M. Hoffman, Michael H. Brodsky, Brynn H Cardozo, Marina Zieger, Andrew Cox
Publikováno v:
Proceedings of the National Academy of Sciences. 115:2788-2793
Chronic obstructive pulmonary disease affects 10% of the worldwide population, and the leading genetic cause is α-1 antitrypsin (AAT) deficiency. Due to the complexity of the murine locus, which includes up to six Serpina1 paralogs, no genetic anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d28774572eadad4fe78980820ee7019
https://doi.org/10.1073/pnas.1713689115
https://doi.org/10.1073/pnas.1713689115
Autor:
Terence R. Flotte, Alisha M. Gruntman, Florie Borel, Noel G. McElvaney, Emer P. Reeves, Gwladys Gernoux, Christian Mueller, Martha Campbell-Thompson, Margaret Humphries, Farshid N. Rouhani, Bruce C. Trapnell, Roberto Calcedo, Louis M. Messina, Jeffrey D. Chulay, James M. Wilson, Anthony T. Yachnis
Publikováno v:
Molecular Therapy
Alpha-1 antitrypsin deficiency is a monogenic disorder resulting in emphysema due principally to the unopposed effects of neutrophil elastase. We previously reported achieving plasma wild-type alpha-1 antitrypsin concentrations at 2.5%–3.8% of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e132cb146fbf2706f0dd140d1be8316b
https://doi.org/10.1016/j.ymthe.2017.03.029
https://doi.org/10.1016/j.ymthe.2017.03.029