Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Alisha Holtzhausen"'
Autor:
K.M. Tanim, Alisha Holtzhausen, Aashis Thapa, Justus M. Huelse, Douglas K. Graham, H. Shelton Earp
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 14, p 7660 (2024)
In this issue honoring the contributions of Greg Lemke, the Earp and Graham lab teams discuss several threads in the discovery, action, signaling, and translational/clinical potential of MERTK, originally called c-mer, a member of the TYRO3, AXL, and
Externí odkaz:
https://doaj.org/article/b3a4342f94c2413f84b03d52eee8278d
Autor:
Nicholas C. DeVito, Michael Sturdivant, Balamayooran Thievanthiran, Christine Xiao, Michael P. Plebanek, April K.S. Salama, Georgia M. Beasley, Alisha Holtzhausen, Veronica Novotny-Diermayr, John H. Strickler, Brent A. Hanks
Publikováno v:
Cell Reports, Vol 35, Iss 5, Pp 109071- (2021)
Summary: While immune checkpoint blockade is associated with prolonged responses in multiple cancers, most patients still do not benefit from this therapeutic strategy. The Wnt-β-catenin pathway is associated with diminished T cell infiltration; how
Externí odkaz:
https://doaj.org/article/7d2f5f4e3fbf4817a9bfc19438eefb1b
Autor:
Yao Jiang, Yanqiong Zhang, Janet Y. Leung, Cheng Fan, Konstantin I. Popov, Siyuan Su, Jiayi Qian, Xiaodong Wang, Alisha Holtzhausen, Eric Ubil, Yang Xiang, Ian Davis, Nikolay V. Dokholyan, Gang Wu, Charles M. Perou, William Y. Kim, H. Shelton Earp, Pengda Liu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Hyperactivation of Akt promotes tumorigenesis. Here, the authors show that SAV1, a member of Hippo signalling, interacts with Akt to suppress Akt activity and MERTK-mediated Akt phosphorylation relieves this suppression to facilitate Akt oncogenic ac
Externí odkaz:
https://doaj.org/article/b6df3eea370a40a0932a4398891238b5
Autor:
Alessandro Porrello, Patrick L. Leslie, Emily B. Harrison, Balachandra K. Gorentla, Sravya Kattula, Subrata K. Ghosh, Salma H. Azam, Alisha Holtzhausen, Yvonne L. Chao, Michele C. Hayward, Trent A. Waugh, Sanggyu Bae, Virginia Godfrey, Scott H. Randell, Cecilia Oderup, Liza Makowski, Jared Weiss, Matthew D. Wilkerson, D. Neil Hayes, H. Shelton Earp, Albert S. Baldwin, Alisa S. Wolberg, Chad V. Pecot
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Lung squamous carcinomas (LUSC) are poorly molecularly characterized, but sub-populations show promising response to immune checkpoint inhibitors. Here, the authors identify a subset of LUSC characterized by infiltration of inflammatory monocytes, wh
Externí odkaz:
https://doaj.org/article/98a06355bdd34530b4587e1a8b9d1ffe
Autor:
Balamayooran Theivanthiran, Tarek Haykal, Linda Cao, Alisha Holtzhausen, Michael Plebanek, Nicholas C. DeVito, Brent A. Hanks
Publikováno v:
Cancers, Vol 13, Iss 19, p 4753 (2021)
The tumor-intrinsic NOD-like receptor family, pyrin-domain-containing-3 (NLRP3) inflammasome, plays an important role in regulating immunosuppressive myeloid cell populations in the tumor microenvironment (TME). While prior studies have described the
Externí odkaz:
https://doaj.org/article/ab8c82ea3b464502b84c12ff446ae703
Autor:
H. Shelton Earp, Stephen V. Frye, Douglas K. Graham, Xiaodong Wang, Qingyang Liu, Dehui Zhang, Yuewei Zhang, Jichen Zhao, Debra M. Hunter, Eric Ubil, William Harris, Alisha Holtzhausen
Supplementary Figures 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93f3ef7f6c3accd5340b3bf4b5b3217a
https://doi.org/10.1158/2326-6066.22542306
https://doi.org/10.1158/2326-6066.22542306
Autor:
H. Shelton Earp, Stephen V. Frye, Douglas K. Graham, Xiaodong Wang, Qingyang Liu, Dehui Zhang, Yuewei Zhang, Jichen Zhao, Debra M. Hunter, Eric Ubil, William Harris, Alisha Holtzhausen
legends for sup figures 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9de457e9fe37e53e01683414037c6b4
https://doi.org/10.1158/2326-6066.22542309.v1
https://doi.org/10.1158/2326-6066.22542309.v1
Autor:
H. Shelton Earp, Stephen V. Frye, Douglas K. Graham, Xiaodong Wang, Qingyang Liu, Dehui Zhang, Yuewei Zhang, Jichen Zhao, Debra M. Hunter, Eric Ubil, William Harris, Alisha Holtzhausen
Myeloid cell receptor tyrosine kinases TYRO3, AXL, and MERTK and their ligands, GAS6 and PROTEIN S, physiologically suppress innate immune responses, including in the tumor microenvironment. Here, we showed that myeloid-derived suppressor cells (MDSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a87e9e526e0bee53729374004e7ea1b
https://doi.org/10.1158/2326-6066.c.6549867.v1
https://doi.org/10.1158/2326-6066.c.6549867.v1
Autor:
Brent A. Hanks, Gerard C. Blobe, Peter J. Siska, Alisha Holtzhausen, Balamayooran Theivanthiran, Nicholas DeVito, Christine Xiao, Kathy Evans, Fei Zhao
EFfect of TGFbeta blockade on TIL PD-1 surface expression.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73e071482ecc8815758bdd2708b0fee6
https://doi.org/10.1158/2326-6066.22539848
https://doi.org/10.1158/2326-6066.22539848
Autor:
Brent A. Hanks, Gerard C. Blobe, Peter J. Siska, Alisha Holtzhausen, Balamayooran Theivanthiran, Nicholas DeVito, Christine Xiao, Kathy Evans, Fei Zhao
Although anti–PD-1 therapy has improved clinical outcomes for select patients with advanced cancer, many patients exhibit either primary or adaptive resistance to checkpoint inhibitor immunotherapy. The role of the tumor stroma in the development o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5a7deaeeb483f89de37ea96a81d601b
https://doi.org/10.1158/2326-6066.c.6549194.v1
https://doi.org/10.1158/2326-6066.c.6549194.v1