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The synthesis of novel analogues of the manumycin family of antibiotics and the antitumour antibiotic LL-C10037α

Autor: Isabelle Kapfer, Gregor Macdonald, Richard J. K. Taylor, Lewis Norman John

Publikováno v: Tetrahedron Letters. 37:2101-2104

Efficient approaches to the central amino-epoxycyclohexenone core of the manumycin family of antibiotics are described. The use of this methodology to prepare the antitumour antibiotic LL-C10037α and its epimer, both in racemic form, and a number of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d74d27ed89471ec95b40bfcf0dbb84ab
https://doi.org/10.1016/0040-4039(96)00203-1

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ChemInform Abstract: The First Total Synthesis of a Member of the Manumycin Family of Antibiotics: Alisamycin

Autor: Lewis Norman John, Isabelle Kapfer, Lilian Alcaraz, Gregor Macdonald, Richard J. K. Taylor

Publikováno v: ChemInform. 27

The development of a general synthetic route to the manumycin family of antibiotics is described and exemplified by the first total synthesis of alisamycin in racemic form.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d1b81c7d92274b30837b67f17a79f9b3
https://doi.org/10.1002/chin.199651209

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ChemInform Abstract: The Synthesis of Alisamycin, Nisamycin, LL-C10037α and Novel Epoxyquinol and Epoxyquinone Analogues of Manumycin A

Autor: Lilian Alcaraz, Xudong Wei, Isabelle Kapfer-Eyer, Richard J. K. Taylor, Gregor Macdonald, Lewis Norman John

Publikováno v: ChemInform. 29

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f43ca350e579b52e8a130365579070c3
https://doi.org/10.1002/chin.199828339

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ChemInform Abstract: Asymmetric Synthesis of the mC7N Core of the Manumycin Family: Preparation of (+)-MT 35214 and a Formal Total Synthesis of (-)-Alisamycin

Autor: Lilian Alcaraz, Gregor Macdonald, Lewis Norman John, Richard J. K. Taylor

Publikováno v: ChemInform. 29

An asymmetric approach to the mC7N epoxyquinone central unit of the manumycin antibiotics is described based on the enantioselective (89% ee) chiral phase transfer epoxidation of a substituted cyclohexenone. The chiral epoxide is employed in the firs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df390670285e54bb0661935080465dc0
https://doi.org/10.1002/chin.199843266

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On the structure of alisamycin, a new member of the manumycin class of antibiotics

Autor: Bimal Naresh Dr Ganguli, H. Kogler, H. W. Fehlhaber, Sugata Chatterjee, Jurgen Blumbach, E. K. S. Vijayakumar, Christopher M. M. Franco

Publikováno v: The Journal of antibiotics. 46(6)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bac90d9e8595c8d4f7a428aee63a608
https://pubmed.ncbi.nlm.nih.gov/8344865

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Absolute Stereochemistry of Alisamycin

Autor: Tomoyuki Fujita, Ken-ichiro Hayashi, Mitsuru Nakayama, Masahira Nakagawa

Publikováno v: Bioscience, Biotechnology, and Biochemistry. 58:1332-1333

Alisamycin is a new manumycin group antibiotic. Manumycin group antibiotics have three asymmetric carbons at C4, C5, and C6 in their structures. The absolute structure of alisamycin was determined by the exciton chirality method and CD spectrum of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8b681d971f8f2c005fadeee522e2af0f
https://doi.org/10.1271/bbb.58.1332

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