Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alisa S.W. Shum"'
Publikováno v:
Methods in Molecular Biology ISBN: 9781493995844
The effect of all-trans retinoic acid (RA) on embryogenesis is tissue specific and highly concentration dependent. Using a liquid chromatography/mass spectrometry-based method to quantify trace amounts of RA in embryonic tissue requires expensive spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::258c3ab61d33f7ad81ddf5563b88f8a2
https://doi.org/10.1007/978-1-4939-9585-1_13
https://doi.org/10.1007/978-1-4939-9585-1_13
Autor:
Alisa S.W. Shum, Leo M Y Lee, Rachel C.Y. Kwok, Maran B.W. Leung, Peter McCaffery, Yun Chung Leung, Andrew J. Copp, Chi Chiu Wang
Publikováno v:
Diabetes. 66(4)
Pregestational diabetes is highly associated with an increased risk of birth defects. However, factors that can increase or reduce the expressivity and penetrance of malformations in pregnancies in women with diabetes remain poorly identified. All-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c827eb4677984335ad3dce703d646458
https://pubmed.ncbi.nlm.nih.gov/28087565
https://pubmed.ncbi.nlm.nih.gov/28087565
Autor:
Heung Ling Choi, Peter McCaffery, Yun Chung Leung, Adrian S. Woolf, Leo M Y Lee, Chi Chiu Wang, Chun Yin Leung, Walfred W. C. Tang, Alisa S.W. Shum
Retinoic acid, an active metabolite of vitamin A, plays essential signaling roles in mammalian embryogenesis. Nevertheless, it has long been recognized that overexposure to vitamin A or retinoic acid causes widespread teratogenesis in rodents as well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f63390ae1e7764d7cdfe6f0b942376
https://europepmc.org/articles/PMC3427051/
https://europepmc.org/articles/PMC3427051/
Publikováno v:
Europe PubMed Central
The method of whole embryo culture permits a variety of experimental manipulations to be performed on the mammalian embryo. When used in conjunction with mouse mutants, this technique can provide information on the pathogenetic mechanisms underlying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1fab1818f92266715c192fb40d8db8c
https://pubmed.ncbi.nlm.nih.gov/20732267
https://pubmed.ncbi.nlm.nih.gov/20732267
Publikováno v:
Europe PubMed Central
Delayed closure of the posterior neuropore (PNP) occurs to a variable extent in homozygous mutant curly tail (ct) mouse embryos, and results in the development of spinal neural tube defects (NTD) in 60 % of embryos. Previous studies have suggested th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61bee2b537afb253b00a6ac987327baa
https://doi.org/10.1242/dev.113.2.671
https://doi.org/10.1242/dev.113.2.671
Publikováno v:
Progress in Neurobiology. 35:363-403
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d86e58a6f131fd5ad1759b9c5b55381
https://doi.org/10.1016/0301-0082(90)90037-h
https://doi.org/10.1016/0301-0082(90)90037-h
Autor:
Tze Kin Lau, Kai On Chu, Wai Ying Li, Wai Sing Chong, Chi Pui Pang, Michael S. Rogers, Chi Chiu Wang, Alisa S.W. Shum
Publikováno v:
Free radical biologymedicine. 43(4)
Tea is the most common beverage after water. Concerns have been raised about the safety of tea during pregnancy, especially for embryo development. We aimed at studying the effects of active tea components on developing embryos by in vitro rat embryo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd883961e89f7cbf8e2a9b326bfb5476
https://pubmed.ncbi.nlm.nih.gov/17640562
https://pubmed.ncbi.nlm.nih.gov/17640562
Autor:
Ryan K. C. Yuen, Yu K. Tong, Tse N. Leung, Joanna H.M. Tong, Christy Ferlatte, Lisa Y.S. Chan, Ka F. To, Rossa W.K. Chiu, Y.M. Dennis Lo, Alisa S.W. Shum, Ivy H.N. Wong, John K.C. Chan, Wing Shan Lee, Kwok W. Lo, Cesar S.C. Wong, Tze K. Lau, Jessie Wai-Fong Yuen, Stephen S.C. Chim, Jingly F. Weier
Publikováno v:
The American journal of pathology. 170(3)
The pseudomalignant nature of the placenta prompted us to search for tumor suppressor gene hypermethylation, a phenomenon widely reported in cancer, in the human placenta. Nine tumor suppressor genes were studied. Hypermethylation of the Ras associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840e3afbb1e5573b96fc051bf7051218
https://pubmed.ncbi.nlm.nih.gov/17322379
https://pubmed.ncbi.nlm.nih.gov/17322379
Autor:
Maran B.W. Leung, Herman K W Tse, John A. Gosling, Adrian S. Woolf, Alisa S.W. Shum, Chi Pui Pang, Nicholas D. Hastie, Aswin L. Menke
Renal malformations are common human birth defects that sometimes occur in the context of the caudal regression syndrome. Here, we found that exposure of pregnant mice to all-trans retinoic acid, at a time when the metanephros has yet to form, causes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::452a2e3de26ce2588a42a3ffbed248a8
https://europepmc.org/articles/PMC1606386/
https://europepmc.org/articles/PMC1606386/
Autor:
Alisa S.W. Shum, Toshihiko Shiroishi, Tsuyoshi Koide, Sau-man Yeung, Billy W.H. Chan, Mary R. Loeken, Kwok-siu Chan, Andrew J. Copp, Maran B.W. Leung
Publikováno v:
Diabetes. 51(9)
Maternal diabetes increases the risk of congenital malformations in the offspring of affected pregnancies. This increase arises from the teratogenic effect of the maternal diabetic milieu on the developing embryo, although the mechanism of this actio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fa1068ced7fe0fff31beafbcade9ab
https://pubmed.ncbi.nlm.nih.gov/12196475
https://pubmed.ncbi.nlm.nih.gov/12196475