Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Alisa E. Shaw"'
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113914- (2024)
Summary: Stroke, trauma, and neurodegenerative disorders cause loss of neurites (axons and dendrites) in addition to neuronal death. Neurite loss may result directly from a primary insult, secondary to parental neuron death, or secondary to a post-in
Externí odkaz:
https://doaj.org/article/c4cbfc71e8b7472ab749b65524aba512
Autor:
Thomas B. Kuhn, Laurie S. Minamide, Lubna H. Tahtamouni, Sydney A. Alderfer, Keifer P. Walsh, Alisa E. Shaw, Omar Yanouri, Henry J. Haigler, Michael R. Ruff, James R. Bamburg
Publikováno v:
Biomedicines, Vol 12, Iss 1, p 93 (2024)
Synapse loss is the principal cause of cognitive decline in Alzheimer’s disease (AD) and related disorders (ADRD). Synapse development depends on the intricate dynamics of the neuronal cytoskeleton. Cofilin, the major protein regulating actin dynam
Externí odkaz:
https://doaj.org/article/f60832bd48fa40ffa411a9cbf6956596
Autor:
Lisa K Smith, Isaac W Babcock, Laurie S Minamide, Alisa E Shaw, James R Bamburg, Thomas B Kuhn
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248309 (2021)
Nearly 50% of individuals with long-term HIV infection are affected by the onset of progressive HIV-associated neurocognitive disorders (HAND). HIV infiltrates the central nervous system (CNS) early during primary infection where it establishes persi
Externí odkaz:
https://doaj.org/article/88f91f1e570f45eca98d7877e15cf852
Autor:
Seok Joon Won, Angela M Minnella, Long Wu, Claire H Eun, Eric Rome, Paco S Herson, Alisa E Shaw, James R Bamburg, Raymond A Swanson
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0198709 (2018)
Functional impairment after brain ischemia results in part from loss of neuronal spines and dendrites, independent of neuronal death. Cofilin-actin rods are covalently linked aggregates of cofilin-1 and actin that form in neuronal processes (neurites
Externí odkaz:
https://doaj.org/article/6e01d2d297074ff19f65214cf4fde775
Publikováno v:
Methods in enzymology. 673
R-loop proteins present a stable and robust blockade to the progression of a DNA replication fork during S-phase. The consequences of this block can include mutagenesis and other irreversible chromosomal catastrophes, causing genomic instability and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::87ac1be6fdc57793509916243d6fa557
https://pubmed.ncbi.nlm.nih.gov/35965008
https://pubmed.ncbi.nlm.nih.gov/35965008
Publikováno v:
Helicase Enzymes Part B ISBN: 9780323997737
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fcc8b402830059f7dfebb975cf78abb4
https://doi.org/10.1016/bs.mie.2022.03.012
https://doi.org/10.1016/bs.mie.2022.03.012
Autor:
Keifer P Walsh, Laurie S Minamide, Sarah J Kane, Alisa E Shaw, David R Brown, Bruce Pulford, Mark D Zabel, J David Lambeth, Thomas B Kuhn, James R Bamburg
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e95995 (2014)
Neurites of neurons under acute or chronic stress form bundles of filaments (rods) containing 1∶1 cofilin∶actin, which impair transport and synaptic function. Rods contain disulfide cross-linked cofilin and are induced by treatments resulting in
Externí odkaz:
https://doaj.org/article/a3df7ff5157a402b8837a2ab94fa9b44
Autor:
Jianjie Mi, Alisa E Shaw, Chi W Pak, Keifer P Walsh, Laurie S Minamide, Barbara W Bernstein, Thomas B Kuhn, James R Bamburg
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83609 (2013)
Filament bundles (rods) of cofilin and actin (1:1) form in neurites of stressed neurons where they inhibit synaptic function. Live-cell imaging of rod formation is hampered by the fact that overexpression of a chimera of wild type cofilin with a fluo
Externí odkaz:
https://doaj.org/article/6b6af92becf44f2bb4468f3c52a3554d
Publikováno v:
J Neurosci
Neuroligins (NLGNs) are a class of postsynaptic cell adhesion molecules that interact with presynaptic neurexins (NRXNs) and regulate synapse function. NLGN4 is a member of the NLGN family and consists of a unique amino acid sequence in humans that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421727280b5151e15e4f4090f900baa2
https://pubmed.ncbi.nlm.nih.gov/33268543
https://pubmed.ncbi.nlm.nih.gov/33268543
Autor:
James R. Bamburg, Alisa E. Shaw
Publikováno v:
Pharmacology & Therapeutics. 175:17-27
Cofilin is a ubiquitous protein which cooperates with many other actin-binding proteins in regulating actin dynamics. Cofilin has essential functions in nervous system development including neuritogenesis, neurite elongation, growth cone pathfinding,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5039d94c0bc7034aa3093807575e725a
https://doi.org/10.1016/j.pharmthera.2017.02.031
https://doi.org/10.1016/j.pharmthera.2017.02.031