Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Alisa E Koch"'
Autor:
Christian S. Thudium, Anne C. Bay-Jensen, Suntara Cahya, Ernst R. Dow, Morten A. Karsdal, Alisa E. Koch, Wenling Zhang, Robert J. Benschop
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-11 (2020)
Abstract Background Tissue released blood-based biomarkers can provide insight into drug mode of action and response. To understand the changes in extracellular matrix turnover, we analyzed biomarkers associated with joint tissue turnover from a phas
Externí odkaz:
https://doaj.org/article/1254e9ec6262489fa11a3d93d2b55517
Mammalian Glycosylation Patterns Protect Citrullinated Chemokine MCP-1/CCL2 from Partial Degradation
Autor:
Olexandr Korchynskyi, Ken Yoshida, Nataliia Korchynska, Justyna Czarnik-Kwaśniak, Paul P. Tak, Ger J. M. Pruijn, Takeo Isozaki, Jeffrey H. Ruth, Phillip L. Campbell, M. Asif Amin, Alisa E. Koch
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 1862 (2023)
Monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemotactic agent for monocytes, primarily produced by macrophages and endothelial cells. Significantly elevated levels of MCP-1/CCL2 were found in synovial fluids of patients with rheumatoi
Externí odkaz:
https://doaj.org/article/f3c195db6ed64a3498c98fc2e1f8e94a
Autor:
Martin J. O’Brien, Qiang Shu, W.Alexander Stinson, Pei-Suen Tsou, Jeffrey H. Ruth, Takeo Isozaki, Phillip L. Campbell, Ray A. Ohara, Alisa E. Koch, David A. Fox, M. Asif Amin
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-8 (2018)
Abstract Background Galectin-9 (Gal-9) is a mammalian lectin secreted by endothelial cells that is highly expressed in rheumatoid arthritis synovial tissues and synovial fluid. Roles have been proposed for galectins in the regulation of inflammation
Externí odkaz:
https://doaj.org/article/4f63b3bffec345f58497e6ec184a9263
Autor:
Nirit Mor-Vaknin, Anjan Saha, Maureen Legendre, Carmelo Carmona-Rivera, M Asif Amin, Bradley J. Rabquer, Marta J. Gonzales-Hernandez, Julie Jorns, Smriti Mohan, Srilakshmi Yalavarthi, Dave A. Pai, Kristine Angevine, Shelley J. Almburg, Jason S. Knight, Barbara S. Adams, Alisa E. Koch, David A. Fox, David R. Engelke, Mariana J. Kaplan, David M. Markovitz
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK-t
Externí odkaz:
https://doaj.org/article/2c912d0db4e646ad89d036163808223e
Autor:
Thomas Dörner, Yoshiya Tanaka, Ernst R Dow, Alisa E Koch, Maria Silk, Jorge A Ross Terres, Jonathan T Sims, Zhe Sun, Inmaculada de la Torre, Michelle Petri
Publikováno v:
Annals of the Rheumatic Diseases. 81:1267-1272
ObjectivesTo elucidate the mechanism of action of baricitinib, a Janus kinase (JAK) 1/2 inhibitor, and describe immunological pathways related to disease activity in adults with systemic lupus erythematosus (SLE) receiving standard background therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10af3a850e251d3a16de93b7496ec2d4
https://doi.org/10.1136/annrheumdis-2022-222335
https://doi.org/10.1136/annrheumdis-2022-222335
Autor:
Christian S. Stohler, Phillip L. Campbell, Robert Dantzer, Alan R. Prossin, Jon Kar Zubieta, Alisa E. Koch, Geoffroy Laumet
Publikováno v:
Molecular Psychiatry. 27:831-839
Behavioral conditioning and expectation can have profound impact on animal and human physiology. Placebo, administered under positive expectation in clinical trials, can have potent effects on disease pathology, obscuring active medications. Emerging
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfbfc8bc739bb1e45b140b0dfce20640
https://doi.org/10.1038/s41380-021-01365-x
https://doi.org/10.1038/s41380-021-01365-x
Autor:
Casey Kar-Chan Choong, Mark Belger, Alisa E. Koch, Kristin J. Meyers, Vincent C. Marconi, Hamed Abedtash, Douglas Faries, Venkatesh Krishnan
Publikováno v:
Advances in therapy. 39(10)
To compare the mortality of hospitalized patients with COVID-19 between those that required supplemental oxygen and received dexamethasone with a comparable set of patients who did not receive dexamethasone.We utilized the Premier Health Database to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3166f78d105ead9d19a70eec7a2cfdfd
https://pubmed.ncbi.nlm.nih.gov/35962234
https://pubmed.ncbi.nlm.nih.gov/35962234
Publikováno v:
Mediators of Inflammation, Vol 2014 (2014)
Externí odkaz:
https://doaj.org/article/12b1cf9887524c178ade08003ff2004f
Autor:
Ernst R. Dow, Wenling Zhang, Suntara Cahya, Morten A. Karsdal, Anne-Christine Bay-Jensen, Robert J. Benschop, Christian S. Thudium, Alisa E. Koch
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-11 (2020)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background Tissue released blood-based biomarkers can provide insight into drug mode of action and response. To understand the changes in extracellular matrix turnover, we analyzed biomarkers associated with joint tissue turnover from a phase 3, rand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7891b3d1af9bb0961169868f474d418a
https://doi.org/10.1186/s13075-020-02340-7
https://doi.org/10.1186/s13075-020-02340-7
Autor:
Alisa E. Koch, Bradley J. Rabquer, Brendan A. Veeneman, Sameek Roychowdhury, Ram Shankar Mani, Saravana M. Dhanasekaran, Maxwell Tran, Xiangyi Li, Shanker Kalyana-Sundaram, Nallasivam Palanisamy, Hesham A. Sadek, Mohammad A. Amin, Lei Wang, Wataru Kimura, Arul M. Chinnaiyan, Adam Aslam, Susmita G. Ramanand, Payal Kapur, Xuhong Cao, Aparna Ghosh
Publikováno v:
Cell Reports. 17:2620-2631
Approximately 50% of prostate cancers are associated with gene fusions of the androgen-regulated gene TMPRSS2 to the oncogenic erythroblast transformation-specific (ETS) transcription factor ERG. The three-dimensional proximity of TMPRSS2 and ERG gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b2e1b65f7ee413622fe1bff1d11f45b
https://doi.org/10.1016/j.celrep.2016.11.019
https://doi.org/10.1016/j.celrep.2016.11.019