Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Alisa B Lee-Sherick"'
Autor:
Alexandra Sufit, Alisa B Lee-Sherick, Deborah DeRyckere, Manali Rupji, Bhakti Dwivedi, Marileila Varella-Garcia, Angela M Pierce, Jeanne Kowalski, Xiaodong Wang, Stephen V Frye, H Shelton Earp, Amy K Keating, Douglas K Graham
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0165107 (2016)
MER receptor tyrosine kinase (MERTK) is expressed in a variety of malignancies, including glioblastoma multiforme (GBM). Our previous work demonstrated that inhibition of MERTK using RNA interference induced cell death and chemosensitivity in GBM cel
Externí odkaz:
https://doaj.org/article/cc1e6a7a41364cb99820e9c9e5a6c231
Autor:
Joselyn Cruz Cruz, Kristen C. Allison, Lauren S. Page, Alexis J. Jenkins, Xiaodong Wang, H. Shelton Earp, Stephen V. Frye, Douglas K. Graham, Michael R. Verneris, Alisa B. Lee-Sherick
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundPrevious studies show that the spleen and bone marrow can serve as leukemia microenvironments in which macrophages play a significant role in immune evasion and chemoresistance. We hypothesized that the macrophage driven tolerogenic process
Externí odkaz:
https://doaj.org/article/6c936b3c3cbd434da91afc7829838a3a
Autor:
Leonora Rose Slatnick, Kristen Miller, Halden F. Scott, Michele Loi, Adam J. Esbenshade, Anna Franklin, Alisa B. Lee-Sherick
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
IntroductionDetermining which febrile pediatric hematology/oncology (PHO) patients will decompensate from severe infection is a significant challenge. Serum lactate is a well-established marker of illness severity in general adult and pediatric popul
Externí odkaz:
https://doaj.org/article/c2c31393487248edbbc6ed89dbe13a76
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
For many pediatric sarcoma patients, multi-modal therapy including chemotherapy, radiation, and surgery is sufficient to cure their disease. However, event-free and overall survival rates for patients with more advanced disease are grim, necessitatin
Externí odkaz:
https://doaj.org/article/35d9101979f94b0bbad413b66aa50acc
Autor:
Alisa B. Lee-Sherick, Kristen M. Jacobsen, Curtis J. Henry, Madeline G. Huey, Rebecca E. Parker, Lauren S. Page, Amanda A. Hill, Xiaodong Wang, Stephen V. Frye, H. Shelton Earp, Craig T. Jordan, Deborah DeRyckere, Douglas K. Graham
Publikováno v:
JCI Insight, Vol 5, Iss 23 (2020)
Externí odkaz:
https://doaj.org/article/1697272d99124244a315c31b3901c007
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Weihe Zhang, Stephanie A. Montgomery, Fatma Eryildiz, Gregory G. Kirkpatrick, Lauren S. Page, Kristen M. Jacobsen, Jeffrey W. Tyner, Amanda A. Hill, Madeline G. Huey, Alisa B. Lee-Sherick, Deborah DeRyckere
Purpose: MERTK tyrosine kinase is ectopically expressed in 30% to 50% of acute lymphoblastic leukemias (ALL) and more than 80% of acute myeloid leukemias (AML) and is a potential therapeutic target. Here, we evaluated the utility of UNC2025, a MERTK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0bc96c5049392bd0f57dc4946300afd
https://doi.org/10.1158/1078-0432.c.6525684.v1
https://doi.org/10.1158/1078-0432.c.6525684.v1
Autor:
Douglas K. Graham, H. Shelton Earp, Stephen V. Frye, Xiaodong Wang, Weihe Zhang, Stephanie A. Montgomery, Fatma Eryildiz, Gregory G. Kirkpatrick, Lauren S. Page, Kristen M. Jacobsen, Jeffrey W. Tyner, Amanda A. Hill, Madeline G. Huey, Alisa B. Lee-Sherick, Deborah DeRyckere
Supplemental Table 1: Antibody Suppliers and Catalog Numbers Supplemental Table 2: Cell Cycle Profiles in Acute Leukemia Cell Lines Treated with UNC2025. Mean values, standard errors, and p values compared to vehicle treatment from 3 independent expe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f07c4d6207a164807bf499cc0db92cf
https://doi.org/10.1158/1078-0432.22464357
https://doi.org/10.1158/1078-0432.22464357
Autor:
Douglas K. Graham, Lauren S. Page, Rebecca E. Parker, Madeline G. Huey, Curtis J. Henry, Deborah DeRyckere, H. Shelton Earp, Kristen M. Jacobsen, Stephen V. Frye, Alisa B. Lee-Sherick, Amanda A. Hill, Craig T. Jordan, Xiaodong Wang
Publikováno v:
JCI Insight
JCI Insight, Vol 5, Iss 23 (2020)
JCI Insight, Vol 5, Iss 23 (2020)
MERTK is ectopically expressed and promotes survival in acute lymphoblastic leukemia (ALL) cells and is thus a potential therapeutic target. Here we demonstrate both direct therapeutic effects of MERTK inhibition on leukemia cells and induction of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bab329a4bbad0adf4c6cc7fa0fa370fd
https://pubmed.ncbi.nlm.nih.gov/30385715
https://pubmed.ncbi.nlm.nih.gov/30385715
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Frontiers in Oncology
Frontiers in Oncology
For many pediatric sarcoma patients, multi-modal therapy including chemotherapy, radiation, and surgery is sufficient to cure their disease. However, event-free and overall survival rates for patients with more advanced disease are grim, necessitatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ce8ec6177349d4043878db0f06fdd0
https://www.frontiersin.org/articles/10.3389/fonc.2020.581107/full
https://www.frontiersin.org/articles/10.3389/fonc.2020.581107/full
Autor:
Deborah DeRyckere, Katina M. Wilson, Brian R. Branchford, J. Di Paola, Gilbert Acevedo, Pavel Davizon-Castillo, Douglas K. Graham, Katherine A. Minson, Keith B. Neeves, Alisa B. Lee-Sherick, Christine Brzezinski, L. Law, Steven R. Lentz, Weihe Zhang, Xiaodong Wang, Timothy J. Stalker, H. Shelton Earp, Lawrence F. Brass, Stephen V. Frye, Christopher J. Ng, Susan Sather
Publikováno v:
Journal of Thrombosis and Haemostasis. 16:352-363
Essentials Signaling by Gas6 through Tyro3/Axl/Mer receptors is essential for stable platelet aggregation. UNC2025 is a small molecule inhibitor of the Mer tyrosine kinase. UNC2025 decreases platelet activation in vitro and thrombus formation in vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e745ea8a38cf239901e8f4d9bf33229e
https://doi.org/10.1111/jth.13875
https://doi.org/10.1111/jth.13875