Výsledky vyhledávání - "Alireza Moeenrezakhanlou"

Myeloid Cell IL-10 Production in Response to Leishmania Involves Inactivation of Glycogen Synthase Kinase-3β Downstream of Phosphatidylinositol-3 Kinase

Autor: Judith M. Silverman, Jennifer Subek, Neil E. Reiner, Alireza Moeenrezakhanlou, Devki Nandan, Martin Lopez, Carolina Camargo de Oliveira

Publikováno v: The Journal of Immunology. 188:367-378

Leishmania disease expression has been linked to IL-10. In this study, we investigated the regulation of IL-10 production by macrophages infected with Leishmania donovani. Infection of either murine or human macrophages brought about selective phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0305740a1b3de0f43d2509382ace1571
https://doi.org/10.4049/jimmunol.1100076

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Mouse Pancreatic Islets Are Resistant to Indoleamine 2,3 Dioxygenase-Induced General Control Nonderepressible-2 Kinase Stress Pathway and Maintain Normal Viability and Function

Autor: Alireza Moeenrezakhanlou, Reza B. Jalili, Ray V. Rajotte, Aziz Ghahary, Farshad Forouzandeh, Hasan Uludağ, Gina R. Rayat

Publikováno v: The American Journal of Pathology. 174:196-205

Islet transplantation is a promising treatment for diabetes. However, it faces several challenges including requirement of systemic immunosuppression. Indoleamine 2,3-dioxygenase (IDO), a tryptophan degrading enzyme, is a potent immunomodulatory fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b04debf3405a4b9af4cb401f4420cc2
https://doi.org/10.2353/ajpath.2009.080539

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Myeloid cell differentiation in response to calcitriol for expressionCD11bandCD14is regulated by myeloid zinc finger-1 protein downstream of phosphatidylinositol 3-kinase

Autor: Neil E. Reiner, Alireza Moeenrezakhanlou, Lucia Lam, Lindsay Shephard

Publikováno v: Journal of Leukocyte Biology. 84:519-528

Immature cells of the mononuclear phagocyte series differentiate in response to calcitriol. This is accompanied by increased expression of both CD11b and CD14 and has been shown to be phosphatidylinositol 3-kinase (PI3K) dependent. The events downstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c4af96049d4488d1490c612186a237
https://doi.org/10.1189/jlb.1207833

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Identification of a Calcitriol-Regulated Sp-1 Site in the Promoter of Human CD14 using a Combined Western Blotting Electrophoresis Mobility Shift Assay (WEMSA)

Autor: Alireza Moeenrezakhanlou, Devki Nandan, Neil E. Reiner

Publikováno v: Biological Procedures

Calcitriol (1alpha, 25-dihydroxyvitamin D(3)) induces the expression of CD14 in mononuclear phagocytes. The mechanisms accounting for this have been unclear since the promoter of CD14 does not contain a canonical vitamin D response element (VDRE). Ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24db2a38a20942706bb741e38be64d16
http://europepmc.org/articles/PMC2275043

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1α,25-Dihydroxycholecalciferol activates binding of CREB to a CRE site in the CD14 promoter and drives promoter activity in a phosphatidylinositol-3 kinase-dependent manner

Autor: Neil E. Reiner, Lindsay Shephard, Devki Nandan, Alireza Moeenrezakhanlou

Publikováno v: Journal of Leukocyte Biology. 81:1311-1321

1,25-Dihydroxycholecalciferol, also known as 1α,25-dihydroxyvitamin D3 or calcitriol, regulates the differentiation and functional properties of mononuclear phagocytes. Many of these effects involve nongenomic signaling pathways, which are not fully

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c4c68708c7adc14a6f4395cf256ee45
https://doi.org/10.1189/jlb.1106681

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Monocyte p110alpha phosphatidylinositol 3-kinase regulates phagocytosis, the phagocyte oxidase, and cytokine production

Autor: Gerald Krystal, Neil E. Reiner, James Lee, Jamie M. Schlomann, Kevin G. Leidal, Laura M. Sly, William M. Nauseef, Alireza Moeenrezakhanlou, Sanaa Noubir

Publikováno v: Journal of leukocyte biology. 81(6)

Mononuclear phagocytes are critical modulators and effectors of innate and adaptive immune responses, and PI-3Ks have been shown to be multifunctional monocyte regulators. The PI-3K family includes eight catalytic isoforms, and only limited informati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8359aa3e9558200e4605f9a46466308e
https://pubmed.ncbi.nlm.nih.gov/17369495

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Annexin V associates with the IFN-gamma receptor and regulates IFN-gamma signaling

Autor: Devki Nandan, Martin Lopez, Neil E. Reiner, Alireza Moeenrezakhanlou, Carlos G. Leon

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 176(10)

Many of the biological activities of IFN-gamma are mediated through the IFN-gammaR3-linked Jak-Stat1alpha pathway. However, regulation of IFN-gamma signaling is not fully understood, and not all responses to IFN-gamma are Stat1alpha dependent. To ide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6329e743fd56f791382de17a623051cf
https://pubmed.ncbi.nlm.nih.gov/16670301

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