Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alireza, Paikari"'
Autor:
Taeko Inoue, Janice A. Zawaski, Vivien Sheehan, Celeste Kanne, Alireza Paikari, Caterina C. Kaffes, Poonam Sarkar, Omaima M. Sabek, M. Waleed Gaber
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 5 (2018)
Background: Acute radiation syndrome (ARS) affects morbidity and mortality dependent on the amount of body exposed. We propose the use of echocardiography (EC) to differentiate between survivors and non-survivors by measuring changes in cardiac funct
Externí odkaz:
https://doaj.org/article/dbf063ec84504dd0a5141d7f4ee3f6fc
Autor:
Gang Bao, Vivien A. Sheehan, Matthew H. Porteus, Alireza Paikari, So Hyun Park, Waracharee Srifa, Yankai Zhang, Alicia K Chang, Timothy H. Davis, Ciaran M. Lee, Joab Camarena, Daniel P. Dever
Publikováno v:
Nucleic Acids Research
Sickle cell disease (SCD) is a monogenic disorder that affects millions worldwide. Allogeneic hematopoietic stem cell transplantation is the only available cure. Here, we demonstrate the use of CRISPR/Cas9 and a short single-stranded oligonucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76f1bd8a03d5ae500c3537167d80c57
https://doi.org/10.1093/nar/gkz475
https://doi.org/10.1093/nar/gkz475
Autor:
Alireza Paikari, Carly C. Ginter Summarell, Jacy R. Crosby, Pavel Sumazin, Yankai Zhang, Eric Boerwinkle, Vivien A. Sheehan, Mitchell J. Weiss
Publikováno v:
Blood. 132:321-333
Induction of red blood cell (RBC) fetal hemoglobin (HbF; α2γ2) ameliorates the pathophysiology of sickle cell disease (SCD) by reducing the concentration of sickle hemoglobin (HbS; α2β(S)2) to inhibit its polymerization. Hydroxyurea (HU), the onl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::292a45c8d366fc7b0dae12adad3d70f3
https://doi.org/10.1182/blood-2017-11-814335
https://doi.org/10.1182/blood-2017-11-814335
Autor:
Alireza Paikari, Vivien A. Sheehan
Publikováno v:
British Journal of Haematology. 180:189-200
Fetal haemoglobin (HbF, α2γ2) induction has long been an area of investigation, as it is known to ameliorate the clinical complications of sickle cell disease (SCD). Progress in identifying novel HbF-inducing strategies has been stymied by limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f35b0989d7186f3d0cec823c8b93e23a
https://doi.org/10.1111/bjh.15021
https://doi.org/10.1111/bjh.15021
Autor:
Christopher C. Benz, Christina Yau, Marc A. Dall'Era, Cassandra D. Belair, Robert Blelloch, Alireza Paikari, Archana Shenoy, Jeff Simko, Felix Moltzahn
Publikováno v:
EMBO reports, vol 16, iss 9
In human prostate cancer, the microRNA biogenesis machinery increases with prostate cancer progression. Here, we show that deletion of the Dgcr8 gene, a critical component of this complex, inhibits tumor progression in a Pten ‐knockout mouse model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e0bc1039f4ed32e3f18277485655e9
https://doi.org/10.15252/embr.201439925
https://doi.org/10.15252/embr.201439925
Publikováno v:
Development (Cambridge, England). 144(20)
The vertebrate-specific ESCC microRNA family arises from two genetic loci in mammals: miR-290/miR-371 and miR-302. The miR-302 locus is found broadly among vertebrates, whereas the miR-290/miR-371 locus is unique to eutheria, suggesting a role in pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b52180b202ec2e34906f668994f83ec
https://pubmed.ncbi.nlm.nih.gov/28935707
https://pubmed.ncbi.nlm.nih.gov/28935707
Publikováno v:
Development.
A family of vertebrate-specific microRNAs called the ESCC microRNAs arises from two genetic loci in mammals, the miR-290/miR-371 and miR-302 loci. While the miR-302 locus is found broadly among vertebrates, the miR-290/miR-371 locus is unique to euth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::92b2ced823a15094abdbaa44eac39697
https://doi.org/10.1242/dev.151654
https://doi.org/10.1242/dev.151654
Publikováno v:
Blood. 134:2265-2265
Background: Glucose transporter 1 (GLUT1) is a ubiquitously expressed protein highly expressed on the surface of erythrocytes. As a member of insulin signaling pathway, GLUT1 is responsible for basal and growth factor-stimulated glucose uptake. The i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c19add2422beb534a36db7bace02a63
https://doi.org/10.1182/blood-2019-131058
https://doi.org/10.1182/blood-2019-131058
Publikováno v:
Blood. 134:971-971
Background: Hydroxyurea (HU) is highly clinically beneficial in patients with sickle cell disease (SCD). While HU reduces leukocytosis and inflammation, in general, patients with high levels of fetal hemoglobin (HbF) induction experience the greatest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::75836a884c052e9a955803ddaafd128a
https://doi.org/10.1182/blood-2019-131214
https://doi.org/10.1182/blood-2019-131214
Autor:
Evadnie Rampersaud, Pavel Sumazin, Tian Mi, Jane S. Hankins, Jeremie H. Estepp, Vivien A. Sheehan, Guolian Kang, Yankai Zhang, Alireza Paikari, Gang Wu, Mitchell J. Weiss
Publikováno v:
Blood. 132:722-722
Background: Fetal hemoglobin (HbF, α2g2) induction is known to reduce the clinical complications of sickle cell anemia (SCA). Progress in identifying novel HbF inducing strategies has been slowed by an incomplete understanding of gamma-globin regula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ff94ab8e962b41d66e9ec2bd448f752
https://doi.org/10.1182/blood-2018-99-115383
https://doi.org/10.1182/blood-2018-99-115383