Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Alioune Ndoye"'
Autor:
Patrick Erbacher, Alioune Ndoye, Jean-Louis Merlin, Alexandre Fifre, Jean-Paul Behr, François Guillemin, Anders Høgset, Gilles Dolivet, Agnès Leroux, Kristian Berg
Publikováno v:
Mol. Ther.
Mol. Ther., 2006, 13, pp.1156-1162
Mol. Ther., 2006, 13, pp.1156-1162
Photochemical internalization (PCI) technology has been used for PEI-mediated p53 gene transfer in mice bearing head and neck squamous cell carcinoma (HNSCC) xenografts. Using luciferase as a reporter gene, PCI led to a 20-fold increase in transgene
Autor:
Jean-Paul Behr, Alioune Ndoye, François Guillemin, Gilles Dolivet, Jean-Louis Merlin, Patrick Erbacher, Sanae Bouali, Agnès Leroux, Kristian Berg
Publikováno v:
International journal of oncology. 25(6)
p53 is frequently mutated in head-and-neck squamous cell carcinoma. Wild-type p53 gene transfer induces apoptosis in vitro and tumor regression in vivo and clinical investigations of p53 gene therapy have been reported, mostly using viral vectors. No
Autor:
Patrick Erbacher, François Guillemin, Kristian Berg, Jean-Paul Behr, Gilles Dolivet, Agnès Leroux, Jean-Louis Merlin, Alioune Ndoye
Publikováno v:
The journal of gene medicine. 6(8)
Background p53 is frequently mutated in many cancers including human head and neck squamous cell carcinoma and pancreatic cancer. In tumor models, wild-type (wt) p53 gene transfer induces apoptosis and tumor regression in vivo, justifying the extensi
Publikováno v:
Drug News & Perspectives. 15:445
The delivery of a functional gene into a tissue can allow the correction of gene defaults or mutations such as those observed in severe hereditary pathologies or in cancer tissues and could lead to gene therapy. To achieve gene transfer, viral vector