Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Aline T. Marinho"'
Autor:
James R. Birtley, Mohammad Alomary, Elisa Zanini, Jane Antony, Zachary Maben, Grant C. Weaver, Claudia Von Arx, Manuela Mura, Aline T. Marinho, Haonan Lu, Eloise V. N. Morecroft, Evdoxia Karali, Naomi E. Chayen, Edward W. Tate, Mollie Jurewicz, Lawrence J. Stern, Chiara Recchi, Hani Gabra
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
OPCML is a tumour suppressor gene that is epigenetically silenced in ovarian cancer and is somatically mutated in various cancers. Here, the authors solve the X-ray crystal structure of OPCML and model clinically relevant mutations that could contrib
Externí odkaz:
https://doaj.org/article/0d39746c3dc44914b53cf2c2f0ee8062
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2019)
Objective: Apolipoprotein A1 (ApoA1) is remarkably decreased in serum and ovarian tissues of ovarian cancer patients. ApoA1 and ApoA1 mimetic peptides can sequestrate pro-inflammatory phospholipids, some of which are known to activate a variety of on
Externí odkaz:
https://doaj.org/article/1f1838e9a01b4dea950aa1be73391fd2
Autor:
Haonan Lu, Mohammad N. Alomary, Hani Gabra, Chiara Recchi, Evdoxia Karali, Edward W. Tate, Naomi E. Chayen, Manuela Mura, Zachary Maben, Grant C. Weaver, Aline T. Marinho, Mollie Jurewicz, James R. Birtley, Eloise V. N. Morecroft, Lawrence J. Stern, Jane Antony, Claudia von Arx, Elisa Zanini
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Nature Communications
Nature Communications
OPCML, a tumor suppressor gene, is frequently silenced epigenetically in ovarian and other cancers. Here we report, by analysis of databases of tumor sequences, the observation of OPCML somatic missense mutations from various tumor types and the impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cfed575691e5c93eb9b8a3de4d31e0
http://link.springer.com/article/10.1038/s41467-019-10966-8
http://link.springer.com/article/10.1038/s41467-019-10966-8
Autor:
Sofia A. Pereira, Aline T. Marinho, Clara Gonçalves-Dias, Umbelina Caixas, Catarina Charneira, M. Matilde Marques, Alexandra M. M. Antunes, Joana P. Miranda, Emília C. Monteiro
Publikováno v:
Drug Metabolism Reviews. 51:76-90
Nevirapine (NVP) is a first-generation non-nucleoside reverse transcriptase inhibitor widely used for the treatment and prophylaxis of human immunodeficiency virus infection. The drug is taken throughout the patient's life and, due to the availabilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::487d2be433a7c2b7d9273549a1a239c6
https://doi.org/10.1080/03602532.2019.1577891
https://doi.org/10.1080/03602532.2019.1577891
Autor:
Mafalda Bourbon, Aline T. Marinho, Sofia A. Pereira, Pedro F. Pinheiro, Alexandra M. M. Antunes, Karina Soto, M. Matilde Marques, Joana P. Miranda, Joana R. Batuca, Umbelina Caixas, Clara G. Dias, Emília C. Monteiro, Teresa Branco
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
The antiretroviral nevirapine (NVP) is associated to a reduction of atherosclerotic lesions and increases in high-density lipoprotein (HDL)-cholesterol. Despite being a hepatotoxic drug, which forbids its re-purposing to other therapeutic areas, not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a6a864be6475b59944e53313659715b
https://hdl.handle.net/10400.18/7907
https://hdl.handle.net/10400.18/7907
Autor:
Parmjit S. Jat, Huda Al-Doujaily, Aline T Marinho, Jonathan D. F. Wadsworth, Madeleine Reilly, Iryna Benilova, Adam Wenborn, Emmanuel Risse, Christian Schmidt, Michael Wiggins De Oliveira, Cassandra Terry, John Collinge, Malin K. Sandberg
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Prions are infectious agents composed of polymers of misfolded prion protein which cause fatal brain diseases such as Creutzfeldt–Jakob disease. These diseases involve progressive loss of neuronal cells, and it has been long assumed th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f789473de13287d64dc5f9171a81f423
https://pubmed.ncbi.nlm.nih.gov/32900920
https://pubmed.ncbi.nlm.nih.gov/32900920
Autor:
Alexandra M. M. Antunes, Sofia A. Pereira, Matilde Castro, Pedro F. Pinheiro, Cristina C. Jacob, Nuno G. Oliveira, Aline T. Marinho, M. Matilde Marques, Joana P. Miranda, Shrika G. Harjivan, Madalena Cipriano, Inês L. Martins
Publikováno v:
Archives of Toxicology. 91:1199-1211
The development of metabolically competent in vitro models is of utmost importance for predicting adverse drug reactions, thereby preventing attrition-related economical and clinical burdens. Using the antiretroviral drug nevirapine (NVP) as a model,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0eaa0d452ab4228e34cb92f8d29c846
https://doi.org/10.1007/s00204-016-1792-x
https://doi.org/10.1007/s00204-016-1792-x
Autor:
Alexandra M. M. Antunes, Aline T. Marinho, Umbelina Caixas, Joana R. Batuca, Emília C. Monteiro, Sofia A. Pereira, Clara G. Dias
Publikováno v:
Anal. Methods. 6:289-294
Paraoxonase-1 (PON1) is known as a free-radical scavenging system associated with circulating serum high-density lipoprotein (HDL). PON1 catalyzes the hydrolysis of multiple compounds such as arylesters, lactones and hydroperoxides. The arylesterase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbda1903fa38c43c693bd9549831eb6c
https://doi.org/10.1039/c3ay41527a
https://doi.org/10.1039/c3ay41527a
Autor:
Sofia A. Pereira, Alexandra M. M. Antunes, M. Matilde Marques, Joana P. Miranda, Pedro F. Pinheiro, Emília C. Monteiro, Aline T. Marinho, Ana Lemos, Clara G. Dias
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 82
Nevirapine is associated with severe hepatotoxicity, through the formation of reactive metabolites. Paraoxonase-1 (PON-1) is a promiscuous enzyme involved in the metabolism of xeno- and endobiotics and proposed as a biomarker of hepatotoxicity. The a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ccfe1f44439a66c4b2a97b26f517340
https://pubmed.ncbi.nlm.nih.gov/26620700
https://pubmed.ncbi.nlm.nih.gov/26620700
Autor:
M. Matilde Marques, Joana P. Miranda, Alexandra M. M. Antunes, Sofia A. Pereira, Aline T. Marinho, Pedro F. Pinheiro
Publikováno v:
Chemico-biological interactions. 233
The understanding of the intestine contribution to drug biotransformation improved significantly in recent years. However, the sources of inter-individual variability in intestinal drug biotransformation, namely sex-differences, are still elusive. Ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19f7d927af5d9dd8a762aef15835fc23
https://pubmed.ncbi.nlm.nih.gov/25818046
https://pubmed.ncbi.nlm.nih.gov/25818046