Genomic study of nonsyndromic hearing loss in unaffected individuals: Frequency of pathogenic and likely pathogenic variants in a Brazilian cohort of 2,097 genomes

Autor: Caio Robledo D’ Angioli Costa Quaio, Antonio Victor Campos Coelho, Livia Maria Silva Moura, Rafael Lucas Muniz Guedes, Kelin Chen, Jose Ricardo Magliocco Ceroni, Renata Moldenhauer Minillo, Marcel Pinheiro Caraciolo, Rodrigo de Souza Reis, Bruna Mascaro Cordeiro de Azevedo, Maria Soares Nobrega, Anne Caroline Barbosa Teixeira, Matheus Martinelli Lima, Thamara Rayssa da Mota, Marina Cadena da Matta, Gabriela Borges Cherulli Colichio, Aline Lulho Roncalho, Ana Flavia Martinho Ferreira, Gabriela Pereira Campilongo, Eduardo Perrone, Luiza do Amaral Virmond, Carolina Araujo Moreno, Joana Rosa Marques Prota, Marina de França, Murilo Castro Cervato, Tatiana Ferreira de Almeida, Joao Bosco de Oliveira Filho

Publikováno v: Frontiers in Genetics, Vol 13 (2022)

Hearing loss (HL) is a common sensory deficit in humans and represents an important clinical and social burden. We studied whole-genome sequencing data of a cohort of 2,097 individuals from the Brazilian Rare Genomes Project who were unaffected by he

Externí odkaz: https://doaj.org/article/a725ec5d20214dbdb3f344e4e8fcf56f

Nitric oxide signalling and antidepressant action revisited

Autor: Gregers Wegener, Samia R. L. Joca, Ariandra G. Sartim, Cassiano F.A. Diniz, Aline Lulho Roncalho

Publikováno v: Joca, S, Sartim, A, Roncalho, A, Diniz, C & Wegener, G 2019, ' Nitric oxide signalling and antidepressant action revisited ', Cell and Tissue Research, vol. 377, no. 1, pp. 45-58 . https://doi.org/10.1007/s00441-018-02987-4
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Cell and Tissue Research

Studies about the pathogenesis of mood disorders have consistently shownthat multiple factors, including genetic and environmental, play a crucial roleon their development and neurobiology. Multiple pathological theories havebeen proposed, of which s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afe16e88a7cab374f9bfc128399ac3c9
https://doi.org/10.1007/s00441-018-02987-4

P2X7 Receptor Signaling in Stress and Depression

Autor: Aline Lulho Roncalho, Henning Ulrich, Gregers Wegener, Deidiane Elisa Ribeiro, Talita Glaser, Sâmia R.L. Joca

Publikováno v: International Journal of Molecular Sciences, Vol 20, Iss 11, p 2778 (2019)
Ribeiro, D E, Roncalho, A L, Glaser, T, Ulrich, H, Wegener, G & Joca, S 2019, ' P2X7 Receptor Signaling in Stress and Depression ', International Journal of Molecular Sciences, vol. 20, no. 11 . https://doi.org/10.3390/ijms20112778
International Journal of Molecular Sciences
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Stress exposure is considered to be the main environmental cause associated with the development of depression. Due to the limitations of currently available antidepressants, a search for new pharmacological targets for treatment of depression is req

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94651b45538677fd446a327567506afa
https://www.mdpi.com/1422-0067/20/11/2778