Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Aline Huguet-Lachon"'
Autor:
Diana M. Dincã, Louison Lallemant, Anchel González-Barriga, Noémie Cresto, Sandra O. Braz, Géraldine Sicot, Laure-Elise Pillet, Hélène Polvèche, Paul Magneron, Aline Huguet-Lachon, Hélène Benyamine, Cuauhtli N. Azotla-Vilchis, Luis E. Agonizantes-Juárez, Julie Tahraoui-Boris, Cécile Martinat, Oscar Hernández-Hernández, Didier Auboeuf, Nathalie Rouach, Cyril F. Bourgeois, Geneviève Gourdon, Mário Gomes-Pereira
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Myotonic dystrophy type 1 (DM1) is characterized by debilitating neurological symptoms. Dinca et al. demonstrate the pronounced impact of DM1 on the morphology and RNA metabolism of astrocytes. Their findings suggest astroglial pathology in DM1 brain
Externí odkaz:
https://doaj.org/article/b8326071658541fb95db0b3ac8971f3d
Autor:
Diana M. Dincã, Louison Lallemant, Anchel González-Barriga, Noémie Cresto, Sandra O. Braz, Géraldine Sicot, Laure-Elise Pillet, Hélène Polvèche, Paul Magneron, Aline Huguet-Lachon, Hélène Benyamine, Cuauhtli N. Azotla-Vilchis, Luis E. Agonizantes-Juárez, Julie Tahraoui-Bories, Cécile Martinat, Oscar Hernández-Hernández, Didier Auboeuf, Nathalie Rouach, Cyril F. Bourgeois, Geneviève Gourdon, Mário Gomes-Pereira
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/38ea75853dc34e0c869d60f3421b8a42
Autor:
Anchel González-Barriga, Louison Lallemant, Diana M. Dincã, Sandra O. Braz, Hélène Polvèche, Paul Magneron, Cédric Pionneau, Aline Huguet-Lachon, Jean-Baptiste Claude, Cerina Chhuon, Ida Chiara Guerrera, Cyril F. Bourgeois, Didier Auboeuf, Geneviève Gourdon, Mário Gomes-Pereira
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder caused by a non-coding CTG repeat expansion in the DMPK gene. This mutation generates a toxic CUG RNA that interferes with the RNA processing of target genes in multiple tissues. Despite deb
Externí odkaz:
https://doaj.org/article/cc14c6fdaf5242e59ed0347ca14de222
Autor:
Brigitte Potier, Louison Lallemant, Sandrine Parrot, Aline Huguet-Lachon, Geneviève Gourdon, Patrick Dutar, Mário Gomes-Pereira
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 2, p 592 (2022)
Myotonic dystrophy type 1 (DM1) is a severe neuromuscular disease mediated by a toxic gain of function of mutant RNAs. The neuropsychological manifestations affect multiple domains of cognition and behavior, but their etiology remains elusive. Transg
Externí odkaz:
https://doaj.org/article/77d80c0858374746838259b98b03f3bc
Autor:
Géraldine Sicot, Laurent Servais, Diana M. Dinca, Axelle Leroy, Cynthia Prigogine, Fadia Medja, Sandra O. Braz, Aline Huguet-Lachon, Cerina Chhuon, Annie Nicole, Noëmy Gueriba, Ruan Oliveira, Bernard Dan, Denis Furling, Maurice S. Swanson, Ida Chiara Guerrera, Guy Cheron, Geneviève Gourdon, Mário Gomes-Pereira
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2718-2729 (2017)
Brain function is compromised in myotonic dystrophy type 1 (DM1), but the underlying mechanisms are not fully understood. To gain insight into the cellular and molecular pathways primarily affected, we studied a mouse model of DM1 and brains of adult
Externí odkaz:
https://doaj.org/article/0dd62c50a731479eb8442d1708f006be
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137620 (2015)
Myotonic dystrophy type 1 (DM1) is caused by an unstable expanded CTG repeat located within the DMPK gene 3'UTR. The nature, severity and age at onset of DM1 symptoms are very variable in patients. Different forms of the disease are described, among
Externí odkaz:
https://doaj.org/article/22177c38b2294691900017f1aa86cdbe
Autor:
Sandrine Parrot, Alex Corscadden, Louison Lallemant, Hélène Benyamine, Jean-Christophe Comte, Aline Huguet-Lachon, Geneviève Gourdon, Mário Gomes-Pereira
Publikováno v:
ACS Chemical Neuroscience
ACS Chemical Neuroscience, American Chemical Society (ACS), 2022, 13 (1), pp.134-142. ⟨10.1021/acschemneuro.1c00634⟩
ACS Chemical Neuroscience, American Chemical Society (ACS), 2022, 13 (1), pp.134-142. ⟨10.1021/acschemneuro.1c00634⟩
International audience; Extracellular glutamate levels are maintained low by efficient transporters, whose dysfunction can cause neuronal hyperexcitability, excitotoxicity, and neurological disease. While many methods estimate glutamate uptake in vit