Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Aline Dantas de Araujo"'
Publikováno v:
Molecular Cancer, Vol 20, Iss 1, Pp 1-18 (2021)
Abstract c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression in mice with only mild and fully reversible side effects, su
Externí odkaz:
https://doaj.org/article/b5e15fa34e2d4140938f5ec859024aa4
Publikováno v:
ChemBioChem. 22:1784-1789
The conventional S-alkylation of cysteine relies upon using activated electrophiles. Here we demonstrate high-yielding and selective S-alkylation and S-lipidation of cysteines in unprotected synthetic peptides and proteins by using weak electrophiles
Autor:
Aline Dantas de Araujo, Patricia López-García, Kerstin Blank, David P. Fairlie, Ana E Bergues-Pupo, Isabell Tunn
Publikováno v:
Angewandte Chemie. 133:234-239
Autor:
David P. Fairlie, Timothy A. Hill, Chongyang Wu, Paul V. Bernhardt, Aline Dantas de Araujo, Huy N. Hoang, Ligong Liu
Publikováno v:
Angewandte Chemie International Edition. 58:18873-18877
The introduction of an amide bond linking side chains of the first and fifth amino acids forms a cyclic pentapeptide that optimally stabilizes the smallest known α-helix in water. The origin of the stabilization is unclear. The observed dependence o
Autor:
Volker Herzig, Aline Dantas de Araujo, Kathryn P. Greenwood, Yanni K.-Y. Chin, Monique J. Windley, Youmie Chong, Markus Muttenthaler, Mehdi Mobli, Neil Audsley, Graham M. Nicholson, Paul F. Alewood, Glenn F. King
Publikováno v:
Biomedicines, Vol 6, Iss 3, p 90 (2018)
Spider venoms are a rich source of insecticidal peptide toxins. Their development as bioinsecticides has, however, been hampered due to concerns about potential lack of stability and oral bioactivity. We therefore systematically evaluated several syn
Externí odkaz:
https://doaj.org/article/376fa61b97e843a3b1e8372ffc8952b0
Publikováno v:
Molecular Cancer
Molecular Cancer, Vol 20, Iss 1, Pp 1-18 (2021)
Molecular Cancer, Vol 20, Iss 1, Pp 1-18 (2021)
c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression in mice with only mild and fully reversible side effects, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7dbcffc6608c1f0d06ec17f80b3676
https://www.repository.cam.ac.uk/handle/1810/343897
https://www.repository.cam.ac.uk/handle/1810/343897
Publikováno v:
Organic Letters. 20:1453-1456
The use of selenocysteines and various cross-linkers to induce helicity in a bioactive peptide is described. The higher reactivity of selenocysteine, relative to cysteine, facilitates rapid cross-linking within unprotected linear peptides under mild
Publikováno v:
ChemBioChem. 22:1686-1686
Autor:
Paula M. Loria, Aline Dantas de Araujo, David Price, Adam J. Cotterell, David A. Griffith, Spiros Liras, Timothy A. Hill, David P. Fairlie, Weijun Xu, David R. Derksen, Robert V. Stanton, Fabien Plisson, Huy N. Hoang, Justin M. Mitchell, David J. Edmonds
Publikováno v:
European Journal of Medicinal Chemistry. 127:703-714
Glucagon-like peptide (GLP-1) is an endogenous hormone that induces insulin secretion from pancreatic islets and modified forms are used to treat diabetes mellitus type 2. Understanding how GLP-1 interacts with its receptor (GLP-1R) can potentially l
Publikováno v:
ACS Medicinal Chemistry Letters. 8:22-26
Protein-protein interactions mediate most physiological and disease processes. Helix-constrained peptides potently mimic or inhibit these interactions by making multiple contacts over large surface areas. However, despite high affinities, they typica