Empagliflozin Inhibits Proximal Tubule NHE3 Activity, Preserves GFR, and Restores Euvolemia in Nondiabetic Rats with Induced Heart Failure

Autor: Juliano Z. Polidoro, Aline Cavalcantti T. Wisnivesky, Gerhard Malnic, Flávio A. Borges-Júnior, Ednei Luiz Antonio, Danúbia Silva dos Santos, Acaris Benetti, Bruno Caramelli, Adriana C. C. Girardi, Paulo José Ferreira Tucci, Renato O. Crajoinas, Leonardo Jensen

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
J Am Soc Nephrol

Background SGLT2 inhibitors reduce the risk of heart failure (HF) mortality and morbidity, regardless of the presence or absence of diabetes, but the mechanisms underlying this benefit remain unclear. Experiments with nondiabetic HF rats tested the h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beb73bcfc379b5e66b357b2330cc2c7c
https://doi.org/10.1681/asn.2020071029