Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi

Autor: Guilherme Curty Lechuga, Júlio Cesar Borges, Claudia Magalhães Calvet, Humberto Pinheiro de Araújo, Aline Araujo Zuma, Samara Braga do Nascimento, Maria Cristina Machado Motta, Alice Maria Rolim Bernardino, Mirian Claudia de Souza Pereira, Saulo Cabral Bourguignon

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 3, Pp 154-164 (2016)

Chagas disease is a neglected tropical disease caused by the flagellated protozoan Trypanosoma cruzi. The current drugs used to treat this disease have limited efficacy and produce severe side effects. Quinolines, nitrogen heterocycle compounds that

Externí odkaz: https://doaj.org/article/4a2648c0a17b48edabc8f84da8374811

Chagas Disease Chemotherapy: What Do We Know So Far?

Autor: Wanderley de Souza, Aline Araujo Zuma

Publikováno v: Current pharmaceutical design. 27(38)

Chagas disease is a Neglected Tropical Disease (NTD), and although it is endemic in Latin America, it affects around 6-7 million people worldwide. The treatment of Chagas disease is based on benznidazole and nifurtimox, which are the only available d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2ce549985d6a94a8b7e0b3c64fd142
https://pubmed.ncbi.nlm.nih.gov/33593251

Furan derivatives impair proliferation and affect ultrastructural organization of Trypanosoma cruzi and Leishmania amazonensis

Autor: Sourav Chatterjee, Vivek Kumar Gupta, Anushree Achari, Wanderley de Souza, Amanda Cristina de Sousa Leite, Aline Araujo Zuma, Jayaraman Vinayagam, Pinaki Bhattacharjee, Parasuraman Jaisankar, Sara Teixeira de Macedo-Silva, Lucas Souza de Castro

Publikováno v: Experimental parasitology. 224

Chagas disease and leishmaniasis are neglected diseases caused by parasites of the Trypanosomatidae family and together they affect millions of people in the five continents. The treatment of Chagas disease is based on benznidazole, whereas for leish

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3baebd225de93285580525ab337094b9
https://pubmed.ncbi.nlm.nih.gov/33744229

In vitro study of the trypanocidal activity of anilinophenanthrolines against Trypanosoma cruzi

Autor: Simon J. Garden, Aline Araujo Zuma, Ramon Silva, Wanderley de Souza

Publikováno v: Parasitology international. 83

Chagas disease is present in Latin America, North America, Europe, and Asia, where between 6 and 7 million people are infected. This illness is transmitted mainly by the insect vector during blood feeding and by oral transmission. Chagas disease is t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663882eeb7e77d35452a932bb2606905
https://pubmed.ncbi.nlm.nih.gov/33766741

Interactions between 4-aminoquinoline and heme: Promising mechanism against Trypanosoma cruzi

Autor: Maria Cristina M. Motta, Alice M. R. Bernardino, Julio C. Borges, Samara Braga do Nascimento, Humberto Pinheiro de Araújo, Aline Araujo Zuma, Guilherme C. Lechuga, Claudia M. Calvet, Mirian Claudia de Souza Pereira, Saulo Cabral Bourguignon

Publikováno v: International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 6, Iss 3, Pp 154-164 (2016)

Chagas disease is a neglected tropical disease caused by the flagellated protozoan Trypanosoma cruzi. The current drugs used to treat this disease have limited efficacy and produce severe side effects. Quinolines, nitrogen heterocycle compounds that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::626d172cce23705a2e630a0ff5d9e6af
https://doi.org/10.1016/j.ijpddr.2016.07.001