Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alina Schidlitzki"'
Autor:
Philip Hampel, Marie Johne, Björn Gailus, Alexandra Vogel, Alina Schidlitzki, Birthe Gericke, Kathrin Töllner, Wiebke Theilmann, Christopher Käufer, Kerstin Römermann, Kai Kaila, Wolfgang Löscher
Publikováno v:
Neurobiology of Disease, Vol 152, Iss , Pp 105297- (2021)
Increased neuronal expression of the Na-K-2Cl cotransporter NKCC1 has been implicated in the generation of seizures and epilepsy. However, conclusions from studies on the NKCC1-specific inhibitor, bumetanide, are equivocal, which is a consequence of
Externí odkaz:
https://doaj.org/article/2a709dc4887c4da59a0cb341c6f812df
Autor:
Lisa Welzel, David H. Bergin, Alina Schidlitzki, Friederike Twele, Marie Johne, Pavel Klein, Wolfgang Löscher
Publikováno v:
Neurobiology of Disease, Vol 149, Iss , Pp 105227- (2021)
Epileptogenesis, the gradual process that leads to epilepsy after brain injury or genetic mutations, is a complex network phenomenon, involving a variety of morphological, biochemical and functional brain alterations. Although risk factors for develo
Externí odkaz:
https://doaj.org/article/ebf73ea039fa4ed9bcb04004def2080c
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Cumulative evidence collected in recent decades suggests that lysosomal dysfunction contributes to neurodegenerative diseases, especially if amyloid proteins are involved. Among these, alpha-synuclein (aSyn) that progressively accumulates and aggrega
Externí odkaz:
https://doaj.org/article/7e43dc0e4925496c812d2e5c718fb29b
Autor:
Alina Schidlitzki, Pablo Bascuñana, Prashant K. Srivastava, Lisa Welzel, Friederike Twele, Kathrin Töllner, Christopher Käufer, Birthe Gericke, Rahel Feleke, Martin Meier, Andras Polyak, Tobias L. Ross, Ingo Gerhauser, Jens P. Bankstahl, Michael R. Johnson, Marion Bankstahl, Wolfgang Löscher
Publikováno v:
Neurobiology of Disease, Vol 134, Iss , Pp - (2020)
Epilepsy is a complex network phenomenon that, as yet, cannot be prevented or cured. We recently proposed network-based approaches to prevent epileptogenesis. For proof of concept we combined two drugs (levetiracetam and topiramate) for which in sili
Externí odkaz:
https://doaj.org/article/87f6ca923e384f6d9e939b1b144f625c
Autor:
Alina Schidlitzki, Milos Stanojlovic, Céline Fournier, Christopher Käufer, Malte Feja, Birthe Gericke, Marco Garzotti, Richard W.D. Welford, Michel Alexander Steiner, Elodie Angot, Franziska Richter
Publikováno v:
Movement Disorders.
Autor:
Lisa Welzel, Pavel Klein, Wolfgang Löscher, Alina Schidlitzki, Kathrin Töllner, Friederike Twele
Publikováno v:
Epilepsy Research. 151:48-66
Network-based approaches in drug discovery comprise both development of novel drugs interacting with multiple targets and repositioning of drugs with known targets to form novel drug combinations that interact with cellular or molecular networks whos
Autor:
David H. Bergin, Marie Johne, Pavel Klein, Friederike Twele, Alina Schidlitzki, Wolfgang Löscher, Lisa Welzel
Publikováno v:
Neurobiology of Disease, Vol 149, Iss, Pp 105227-(2021)
Epileptogenesis, the gradual process that leads to epilepsy after brain injury or genetic mutations, is a complex network phenomenon, involving a variety of morphological, biochemical and functional brain alterations. Although risk factors for develo
Autor:
Dean J. Aguiar, Wiebke Theilmann, Birthe Gericke, Syed Muhammad Muneeb Anjum, Steven C. Leiser, Dekun Song, Timon Harries, Matthias P. Wymann, Daniela Brunner, Petra Hillmann, Alina Schidlitzki, Steven L. Roberds, Doriano Fabbro, Saskia Borsdorf, Wolfgang Löscher
Publikováno v:
Neuropharmacology. 180
Mechanistic target of rapamycin (mTOR) regulates cell proliferation, growth and survival, and is activated in cancer and neurological disorders, including epilepsy. The rapamycin derivative ("rapalog") everolimus, which allosterically inhibits the mT
Autor:
András Polyák, Christopher Käufer, Marion Bankstahl, Jens P. Bankstahl, Martin Meier, Pablo Bascuñana, Tobias L. Ross, Ingo Gerhauser, Kathrin Töllner, Marvin Johnson, Lisa Welzel, Friederike Twele, Wolfgang Löscher, Alina Schidlitzki, Birthe Gericke, Prashant K. Srivastava, Rahel Feleke
Publikováno v:
Neurobiology of Disease, Vol 134, Iss, Pp-(2020)
Epilepsy is a complex network phenomenon that, as yet, cannot be prevented or cured. We recently proposed network-based approaches to prevent epileptogenesis. For proof of concept we combined two drugs (levetiracetam and topiramate) for which in sili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d96176afa80236ce8cc583503f7fde1c
http://hdl.handle.net/10044/1/76196
http://hdl.handle.net/10044/1/76196
Publikováno v:
Epilepsia Open
Objective There is an ongoing debate about definition of seizures in experimental models of acquired epilepsy and how important adequate sham controls are in this respect. For instance, several mouse and rat strains exhibit high-voltage rhythmic spik