Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Alina Kulakova"'
Autor:
Suk Kyu Ko, Carolin Berner, Alina Kulakova, Markus Schneider, Iris Antes, Gerhard Winter, Pernille Harris, Günther H.J. Peters
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1439-1455 (2022)
Granulocyte-colony stimulating factor (GCSF) is a widely used therapeutic protein to treat neutropenia. GCSF has an increased propensity to aggregate if the pH is increased above 5.0. Although GCSF is very well experimentally characterized, the exact
Externí odkaz:
https://doaj.org/article/e6a3a635f7cf498b8c71c0cef29d35ef
Autor:
Alina Kulakova, Sowmya Indrakumar, Pernille Sønderby, Lorenzo Gentiluomo, Werner Streicher, Dierk Roessner, Wolfgang Frieß, Günther H.J. Peters, Pernille Harris
Publikováno v:
Journal of Structural Biology: X, Vol 4, Iss , Pp 100017- (2020)
Transferrin is an attractive candidate for drug delivery due to its ability to cross the blood brain barrier. However, in order to be able to use it for therapeutic purposes, it is important to investigate how its stability depends on different formu
Externí odkaz:
https://doaj.org/article/a92acadb0a5249629cba80c8d938c834
Autor:
Alina Kulakova, Dillen Augustijn, Inas El Bialy, Lorenzo Gentiluomo, Maria Laura Greco, Stefan Hervø-Hansen, Sowmya Indrakumar, Sujata Mahapatra, Marcello Martinez Morales, Christin Pohl, Marco Polimeni, Aisling Roche, Hristo L. Svilenov, Andreas Tosstorff, Matja Zalar, Robin Curtis, Jeremy P. Derrick, Wolfgang Frieß, Alexander P. Golovanov, Mikael Lund, Allan Nørgaard, Tarik A. Khan, Günther H. J. Peters, Alain Pluen, Dierk Roessner, Werner W. Streicher, Christopher F. van der Walle, Jim Warwicker, Shahid Uddin, Gerhard Winter, Jens Thostrup Bukrinski, Åsmund Rinnan, Pernille Harris
Publikováno v:
Molecular Pharmaceutics.
Autor:
Jan Jaehrling, Pernille Harris, Wolfgang Friess, Susumu Uchiyama, Felix Kummer, Martin Domnowski, Kanta Enomoto, Alina Kulakova, Takahiro Maruno
Publikováno v:
Journal of Pharmaceutical Sciences. 110:1979-1988
Attractive self-interaction processes in antibody formulations increase the risk of aggregation and extraordinarily elevated viscosity at high protein concentrations. These challenges affect manufacturing and application. This study aimed to understa
Conformational stability of human serum transferrin (Tf) at varying pH, salt, and excipient concentrations were investigated using molecular dynamics (MD) simulations and the results are compared with previously published small angle X-ray scattering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31c66671798d9708d9b191ee96dc533
https://doi.org/10.1101/2022.01.28.478130
https://doi.org/10.1101/2022.01.28.478130
Autor:
Werner Streicher, Sujata Mahapatra, Günther H.J. Peters, Allan Nørgaard, Pernille Harris, Christin Pohl, Alina Kulakova
Publikováno v:
Pohl, C, Mahapatra, S, Kulakova, A, Streicher, W, Peters, G H J, Nørgaard, A & Harris, P 2022, ' Combination of high throughput and structural screening to assess protein stability-A screening perspective ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 171 . https://doi.org/10.1016/j.ejpb.2021.08.018
European journal of pharmaceutics and biopharmaceutics 171, 1-10 (2022). doi:10.1016/j.ejpb.2021.08.018
Pohl, C, Mahapatra, S, Kulakova, A, Streicher, W, Peters, G H J, Nørgaard, A & Harris, P 2022, ' Combination of high throughput and structural screening to assess protein stability – A screening perspective ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 171, pp. 1-10 . https://doi.org/10.1016/j.ejpb.2021.08.018
European journal of pharmaceutics and biopharmaceutics 171, 1-10 (2022). doi:10.1016/j.ejpb.2021.08.018
Pohl, C, Mahapatra, S, Kulakova, A, Streicher, W, Peters, G H J, Nørgaard, A & Harris, P 2022, ' Combination of high throughput and structural screening to assess protein stability – A screening perspective ', European Journal of Pharmaceutics and Biopharmaceutics, vol. 171, pp. 1-10 . https://doi.org/10.1016/j.ejpb.2021.08.018
European journal of pharmaceutics and biopharmaceutics 171, 1 - 10 (2022). doi:10.1016/j.ejpb.2021.08.018
High throughput screening for measuring the stability of industrially relevant proteins and their variants is necessary for quality assessm
High throughput screening for measuring the stability of industrially relevant proteins and their variants is necessary for quality assessm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea860997e4adeb3ebbd6a386757edca3
Publikováno v:
Regionalnaya ekonomika. Yug Rossii. :83-93
Modern globalization processes cause the emergence of new threats to society, and necessitate the development of innovative mechanisms to overcome them in order to improve the level of security at various levels of management. The objective of this s
Autor:
Sowmya Indrakumar, Sujata Mahapatra, Alina Kulakova, Werner Streicher, Günther H.J. Peters, Pernille Harris, Pernille Sønderby Tuelung
Publikováno v:
Scientific reports 10(1), 10089 (2020). doi:10.1038/s41598-020-67002-9
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Kulakova, A, Indrakumar, S, Sønderby Tuelung, P, Mahapatra, S, Streicher, W W, Peters, G H J & Harris, P 2020, ' Albumin-neprilysin fusion protein : understanding stability using small angle X-ray scattering and molecular dynamic simulations ', Scientific Reports, vol. 10, no. 1, 10089 . https://doi.org/10.1038/s41598-020-67002-9
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Kulakova, A, Indrakumar, S, Sønderby Tuelung, P, Mahapatra, S, Streicher, W W, Peters, G H J & Harris, P 2020, ' Albumin-neprilysin fusion protein : understanding stability using small angle X-ray scattering and molecular dynamic simulations ', Scientific Reports, vol. 10, no. 1, 10089 . https://doi.org/10.1038/s41598-020-67002-9
Scientific Reports
Scientific reports 10(1), 10089 (2020). doi:10.1038/s41598-020-67002-9
Fusion technology is widely used in protein-drug development to increase activity, stability, and bioavailability of protein therapeutics. Fusion proteins, like any other typ
Fusion technology is widely used in protein-drug development to increase activity, stability, and bioavailability of protein therapeutics. Fusion proteins, like any other typ
Autor:
Marie Skepö, Julia Weikum, Alina Kulakova, Jack C. Leo, Shogo Yoshimoto, J. Preben Morth, Katsutoshi Hori, Giulio Tesei, Pernille Harris, Line Vejby Jægerum, Monika Schütz
Publikováno v:
Weikum, J, Kulakova, A, Tesei, G, Yoshimoto, S, Jægerum, L V, Schütz, M, Hori, K, Skepö, M, Harris, P, Leo, J C & Morth, J P 2020, ' The extracellular juncture domains in the intimin passenger adopt a constitutively extended conformation inducing restraints to its sphere of action ', Scientific Reports, vol. 10, 21249 . https://doi.org/10.1038/s41598-020-77706-7
Scientific Reports
Weikum, J, Vitaliyivna Kulakova, A, Tesei, G, Yoshimoto, S, Jægerum, L V, Schütz, M, Hori, K, Skepö, M, Harris, P, Leo, J C & Morth, J P 2020, ' The extracellular juncture domains in the intimin passenger adopt a constitutively extended conformation inducing restraints to its sphere of action ', Scientific Reports, vol. 10, no. 1, 21249 . https://doi.org/10.1038/s41598-020-77706-7
Scientific reports 10(1), 21249 (2020). doi:10.1038/s41598-020-77706-7
Scientific Reports
Weikum, J, Vitaliyivna Kulakova, A, Tesei, G, Yoshimoto, S, Jægerum, L V, Schütz, M, Hori, K, Skepö, M, Harris, P, Leo, J C & Morth, J P 2020, ' The extracellular juncture domains in the intimin passenger adopt a constitutively extended conformation inducing restraints to its sphere of action ', Scientific Reports, vol. 10, no. 1, 21249 . https://doi.org/10.1038/s41598-020-77706-7
Scientific reports 10(1), 21249 (2020). doi:10.1038/s41598-020-77706-7
Scientific reports 10(1), 21249 (2020). doi:10.1038/s41598-020-77706-7
Enterohemorrhagic and enteropathogenic Escherichia coli are among the most important food-borne pathogens, posing a global health threat. The virulence factor intimin is esse
Enterohemorrhagic and enteropathogenic Escherichia coli are among the most important food-borne pathogens, posing a global health threat. The virulence factor intimin is esse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::023c209e29fde8baa2495ee27655d3c8
https://curis.ku.dk/portal/da/publications/the-extracellular-juncture-domains-in-the-intimin-passenger-adopt-a-constitutively-extended-conformation-inducing-restraints-to-its-sphere-of-action(e47b40d1-c894-4780-a8ae-3aaf17436d9c).html
https://curis.ku.dk/portal/da/publications/the-extracellular-juncture-domains-in-the-intimin-passenger-adopt-a-constitutively-extended-conformation-inducing-restraints-to-its-sphere-of-action(e47b40d1-c894-4780-a8ae-3aaf17436d9c).html
Autor:
Shahid Uddin, Christin Pohl, Christopher F. van der Walle, Inas El Bialy, Jeremy P. Derrick, Andreas Tosstorff, Robin Curtis, Sujata Mahapatra, Werner Streicher, Dillen Augustijn, Aisling Roche, Alina Kulakova, Wolfgang Frieß, Åsmund Rinnan, Hristo L. Svilenov, Dierk Roessner, Lorenzo Gentiluomo, Sowmya Indrakumar, Alain Pluen, Gerhard Winter, Pernille Harris, Allan Nørgaard, Günther H.J. Peters, Maria Laura Greco, Marcello Martinez Morales, Tarik A. Khan
Publikováno v:
Molecular Pharmaceutics
Gentiluomo, L, Svilenov, H L, Augustijn, D, El Bialy, I, Greco, M L, Vitaliyivna Kulakova, A, Indrakumar, S, Mahapatra, S, Morales, M M, Pohl, C, Roche, A, Tosstorff, A, Curtis, R, Derrick, J P, Nørgaard, A, Khan, T A, Peters, G H J, Pluen, A, Rinnan, Å, Streicher, W W, van der Walle, C F, Uddin, S, Winter, G, Roessner, D, Harris, P & Frieß, W 2020, ' Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization ', Molecular Pharmaceutics, vol. 17, no. 2, pp. 426-440 . https://doi.org/10.1021/acs.molpharmaceut.9b00852
Gentiluomo, L, Svilenov, H L, Augustijn, D, El Bialy, I, Greco, M L, Kulakova, A, Indrakumar, S, Mahapatra, S, Morales, M M, Pohl, C, Roche, A, Tosstorff, A, Curtis, R, Derrick, J P, Nørgaard, A, Khan, T A, Peters, G H J, Pluen, A, Rinnan, Å, Streicher, W W, van der Walle, C F, Uddin, S, Winter, G, Roessner, D, Harris, P & Friess, W 2020, ' Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization ', Molecular Pharmaceutics, vol. 17, no. 2, pp. 426-440 . https://doi.org/10.1021/acs.molpharmaceut.9b00852
Gentiluomo, L, Svilenov, H L, Augustijn, D, El Bialy, I, Greco, M L, Vitaliyivna Kulakova, A, Indrakumar, S, Mahapatra, S, Morales, M M, Pohl, C, Roche, A, Tosstorff, A, Curtis, R, Derrick, J P, Nørgaard, A, Khan, T A, Peters, G H J, Pluen, A, Rinnan, Å, Streicher, W W, van der Walle, C F, Uddin, S, Winter, G, Roessner, D, Harris, P & Frieß, W 2020, ' Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization ', Molecular Pharmaceutics, vol. 17, no. 2, pp. 426-440 . https://doi.org/10.1021/acs.molpharmaceut.9b00852
Gentiluomo, L, Svilenov, H L, Augustijn, D, El Bialy, I, Greco, M L, Kulakova, A, Indrakumar, S, Mahapatra, S, Morales, M M, Pohl, C, Roche, A, Tosstorff, A, Curtis, R, Derrick, J P, Nørgaard, A, Khan, T A, Peters, G H J, Pluen, A, Rinnan, Å, Streicher, W W, van der Walle, C F, Uddin, S, Winter, G, Roessner, D, Harris, P & Friess, W 2020, ' Advancing Therapeutic Protein Discovery and Development through Comprehensive Computational and Biophysical Characterization ', Molecular Pharmaceutics, vol. 17, no. 2, pp. 426-440 . https://doi.org/10.1021/acs.molpharmaceut.9b00852
Therapeutic protein candidates should exhibit favorable properties that render them suitable to become drugs. Nevertheless, there are no well-established guidelines for the efficient selection of proteinaceous molecules with desired features during e