Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Alina Isakova"'
Autor:
Victoria N. Parikh, Alexander G. Ioannidis, David Jimenez-Morales, John E. Gorzynski, Hannah N. De Jong, Xiran Liu, Jonasel Roque, Victoria P. Cepeda-Espinoza, Kazutoyo Osoegawa, Chris Hughes, Shirley C. Sutton, Nathan Youlton, Ruchi Joshi, David Amar, Yosuke Tanigawa, Douglas Russo, Justin Wong, Jessie T. Lauzon, Jacob Edelson, Daniel Mas Montserrat, Yongchan Kwon, Simone Rubinacci, Olivier Delaneau, Lorenzo Cappello, Jaehee Kim, Massa J. Shoura, Archana N. Raja, Nathaniel Watson, Nathan Hammond, Elizabeth Spiteri, Kalyan C. Mallempati, Gonzalo Montero-Martín, Jeffrey Christle, Jennifer Kim, Anna Kirillova, Kinya Seo, Yong Huang, Chunli Zhao, Sonia Moreno-Grau, Steven G. Hershman, Karen P. Dalton, Jimmy Zhen, Jack Kamm, Karan D. Bhatt, Alina Isakova, Maurizio Morri, Thanmayi Ranganath, Catherine A. Blish, Angela J. Rogers, Kari Nadeau, Samuel Yang, Andra Blomkalns, Ruth O’Hara, Norma F. Neff, Christopher DeBoever, Sándor Szalma, Matthew T. Wheeler, Christian M. Gates, Kyle Farh, Gary P. Schroth, Phil Febbo, Francis deSouza, Omar E. Cornejo, Marcelo Fernandez-Vina, Amy Kistler, Julia A. Palacios, Benjamin A. Pinsky, Carlos D. Bustamante, Manuel A. Rivas, Euan A. Ashley
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
There is a genetic component to the risk of severe COVID-19, but the genetic effects are difficult to separate from social constructs that covary with genetic ancestry. To address this, the authors identify determinants of COVID-19 severity using adm
Externí odkaz:
https://doaj.org/article/10002eca5587461185e42393a7dc16a5
Autor:
Jing Ren, Alina Isakova, Drew Friedmann, Jiawei Zeng, Sophie M Grutzner, Albert Pun, Grace Q Zhao, Sai Saroja Kolluru, Ruiyu Wang, Rui Lin, Pengcheng Li, Anan Li, Jennifer L Raymond, Qingming Luo, Minmin Luo, Stephen R Quake, Liqun Luo
Publikováno v:
eLife, Vol 8 (2019)
Serotonin neurons of the dorsal and median raphe nuclei (DR, MR) collectively innervate the entire forebrain and midbrain, modulating diverse physiology and behavior. To gain a fundamental understanding of their molecular heterogeneity, we used plate
Externí odkaz:
https://doaj.org/article/eb730726e1314fd5a7371c54603afbe4
Autor:
Carine Gubelmann, Sebastian M Waszak, Alina Isakova, Wiebke Holcombe, Korneel Hens, Antonina Iagovitina, Jean‐Daniel Feuz, Sunil K Raghav, Jovan Simicevic, Bart Deplancke
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp n/a-n/a (2013)
The comprehensive mapping of gene promoters and enhancers has significantly improved our understanding of how the mammalian regulatory genome is organized. An important challenge is to elucidate how these regulatory elements contribute to gene expres
Externí odkaz:
https://doaj.org/article/8aa1f7539d694dd6887873b40aa06f41
Autor:
Christian Schröter, Saúl Ares, Luis G Morelli, Alina Isakova, Korneel Hens, Daniele Soroldoni, Martin Gajewski, Frank Jülicher, Sebastian J Maerkl, Bart Deplancke, Andrew C Oates
Publikováno v:
PLoS Biology, Vol 10, Iss 7, p e1001364 (2012)
During vertebrate embryogenesis, the rhythmic and sequential segmentation of the body axis is regulated by an oscillating genetic network termed the segmentation clock. We describe a new dynamic model for the core pace-making circuit of the zebrafish
Externí odkaz:
https://doaj.org/article/877d839941f6424693533ce27c29264d
Autor:
Viktoria Wagner, Fabian Kern, Oliver Hahn, Nicholas Schaum, Nicole Ludwig, Tobias Fehlmann, Annika Engel, Dominic Henn, Shusruto Rishik, Alina Isakova, Michelle Tan, Rene Sit, Norma Neff, Martin Hart, Eckart Meese, Steve Quake, Tony Wyss-Coray, Andreas Keller
Molecular mechanisms of organismal and cell aging remain incompletely understood. We, therefore, generated a body-wide map of noncoding RNA (ncRNA) expression in aging (16 organs at ten timepoints from 1 to 27 months) and rejuvenated mice. We found m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2eaa31b5f6d227f676637b8013355d7
Autor:
Alina Isakova, Artem Artykov, Yekaterina Vorontsova, Dmitry Dolgikh, Mikhail Kirpichnikov, Marine Gasparian, Anne Yagolovich
Publikováno v:
Molecular biotechnology.
Autoinduction is a simple approach for heterologous protein expression that helps to achieve the high-level production of recombinant proteins in soluble form. In this work, we investigated if the application of an autoinduction strategy could help t
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We report a systematic unbiased analysis of small RNA molecule expression in 11 different tissues of the model organism mouse. We discovered uncharacterized noncoding RNA molecules and identified that ∼30% of total noncoding small RNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdf8911d86eeae159cdae5ffbf8d088
Autor:
Inmaculada Moreno, Alina Isakova, Wenying Pan, Stephen R. Quake, Marco Mignardi, Pilar Alamá, Felipe Vilella, Carlos Simón, Wanxin Wang
Publikováno v:
Nature Medicine. 26:1644-1653
In a human menstrual cycle the endometrium undergoes remodeling, shedding and regeneration, all of which are driven by substantial gene expression changes in the underlying cellular hierarchy. Despite its importance in human fertility and regenerativ
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Each individual cell transcribes nearly 85% of the genome. However, when it comes to the analysis of cellular RNA, most studies are still only looking at the 3% that correspond to protein-coding transcripts. The role and abundance of the
Autor:
Victoria N. Parikh, Alexander G. Ioannidis, David Jimenez-Morales, John E. Gorzynski, Hannah N. De Jong, Xiran Liu, Jonasel Roque, Victoria P. Cepeda-Espinoza, Kazutoyo Osoegawa, Chris Hughes, Shirley C. Sutton, Nathan Youlton, Ruchi Joshi, David Amar, Yosuke Tanigawa, Douglas Russo, Justin Wong, Jessie T. Lauzon, Jacob Edelson, Daniel Mas Montserrat, Yongchan Kwon, Simone Rubinacci, Olivier Delaneau, Lorenzo Cappello, Jaehee Kim, Massa J. Shoura, Archana N. Raja, Nathaniel Watson, Nathan Hammond, Elizabeth Spiteri, Kalyan C. Mallempati, Gonzalo Montero-Martín, Jeffrey Christle, Jennifer Kim, Anna Kirillova, Kinya Seo, Yong Huang, Chunli Zhao, Sonia Moreno-Grau, Steven G. Hershman, Karen P. Dalton, Jimmy Zhen, Jack Kamm, Karan D. Bhatt, Alina Isakova, Maurizio Morri, Thanmayi Ranganath, Catherine A. Blish, Angela J. Rogers, Kari Nadeau, Samuel Yang, Andra Blomkalns, Ruth O’Hara, Norma F. Neff, Christopher DeBoever, Sándor Szalma, Matthew T. Wheeler, Christian M. Gates, Kyle Farh, Gary P. Schroth, Phil Febbo, Francis deSouza, Omar E. Cornejo, Marcelo Fernandez-Vina, Amy Kistler, Julia A. Palacios, Benjamin A. Pinsky, Carlos D. Bustamante, Manuel A. Rivas, Euan A. Ashley
Publikováno v:
Nature communications, vol 13, iss 1
The SARS-CoV-2 pandemic has differentially impacted populations across race and ethnicity. A multi-omic approach represents a powerful tool to examine risk across multi-ancestry genomes. We leverage a pandemic tracking strategy in which we sequence v