Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Alina I. Marusina"'
Autor:
Arta M. Monjazeb, Megan E. Daly, Guillaume Luxardi, Emanual Maverakis, Alexander A. Merleev, Alina I. Marusina, Alexander Borowsky, Amin Mirhadi, Stephen L. Shiao, Laurel Beckett, Shuai Chen, David Eastham, Tianhong Li, Logan V. Vick, Heather M. McGee, Frances Lara, Leslie Garcia, Leigh Anne Morris, Robert J. Canter, Jonathan W. Riess, Kurt A. Schalper, William J. Murphy, Karen Kelly
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Stereotactic ablative radiotherapy (SABR) is a standard-of-care for medically-inoperable-early-stage non-small cell lung cancer (NSCLC). One third of patients progress and chemotherapy is rarely used in this population. We questioned if addi
Externí odkaz:
https://doaj.org/article/28952647439e48d680160b1ba89a37c4
Autor:
Alexander Merleev, Antonio Ji-Xu, Atrin Toussi, Lam C. Tsoi, Stephanie T. Le, Guillaume Luxardi, Xianying Xing, Rachael Wasikowski, William Liakos, Marie-Charlotte Brüggen, James T. Elder, Iannis E. Adamopoulos, Yoshihiro Izumiya, Annie R. Leal, Qinyuan Li, Nikolay Y. Kuzminykh, Amanda Kirane, Alina I. Marusina, Johann E. Gudjonsson, Emanual Maverakis
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
Proprotein convertase subtilisin/kexin type-9 (PCSK9) is a posttranslational regulator of the LDL receptor (LDLR). Recent studies have proposed a role for PCSK9 in regulating immune responses. Using RNA-Seq–based variant discovery, we identified a
Externí odkaz:
https://doaj.org/article/0af5f0392e5144bb91cb11d1e06f87ed
Autor:
Alexander A. Merleev, Stephanie T. Le, Claire Alexanian, Atrin Toussi, Yixuan Xie, Alina I. Marusina, Steven M. Watkins, Forum Patel, Allison C. Billi, Julie Wiedemann, Yoshihiro Izumiya, Ashish Kumar, Ranjitha Uppala, J. Michelle Kahlenberg, Fu-Tong Liu, Iannis E. Adamopoulos, Elizabeth A. Wang, Chelsea Ma, Michelle Y. Cheng, Halani Xiong, Amanda Kirane, Guillaume Luxardi, Bogi Andersen, Lam C. Tsoi, Carlito B. Lebrilla, Johann E. Gudjonsson, Emanual Maverakis
Publikováno v:
JCI Insight, Vol 7, Iss 16 (2022)
The epidermis is the outermost layer of skin. Here, we used targeted lipid profiling to characterize the biogeographic alterations of human epidermal lipids across 12 anatomically distinct body sites, and we used single-cell RNA-Seq to compare kerati
Externí odkaz:
https://doaj.org/article/29f7b5c3c7314462ae63385c896e06c5
Autor:
Stephanie T. Le, Alexander A. Merleev, Guillaume Luxardi, Michiko Shimoda, Iannis E. Adamopoulos, Lam C. Tsoi, Jenny Z. Wang, Claire Alexanian, Siba P. Raychaudhuri, Samuel T. Hwang, Johann Gudjonsson, Alina I. Marusina, Emanual Maverakis
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The present paradigm of psoriasis pathogenesis revolves around the IL-23/IL-17A axis. Dual-secreting Th17 T cells presumably are the predominant sources of the psoriasis phenotype-driving cytokines, IL-17A and IL-22. We thus conducted a meta-analysis
Externí odkaz:
https://doaj.org/article/ee793b68b8a74bf49f481c9601c520be
Autor:
Elizabeth A. Wang, Andrea Steel, Guillaume Luxardi, Anupam Mitra, Forum Patel, Michelle Y. Cheng, Reason Wilken, Jason Kao, Kristopher de Ga, Hawa Sultani, Alexander A. Merleev, Alina I. Marusina, Alain Brassard, Maxwell A. Fung, Thomas Konia, Michiko Shimoda, Emanual Maverakis
Publikováno v:
Frontiers in Immunology, Vol 8 (2018)
BackgroundPyoderma gangrenosum (PG) is a debilitating ulcerative skin disease that is one of the most common associated diseases seen in patients with inflammatory bowel disease and rheumatoid arthritis. Although PG is classified as a neutrophilic de
Externí odkaz:
https://doaj.org/article/fe3ea2b9197646ba9e0c3fd94e1b89c6
Autor:
Cuong Thach Nguyen, Hiroki Furuya, Dayasagar Das, Alina I. Marusina, Alexander A. Merleev, Resmi Ravindran, Zahra Jalali, Imran H. Khan, Emanual Maverakis, Iannis E. Adamopoulos
Publikováno v:
Arthritis & Rheumatology. 74:1524-1534
This study was undertaken to identify the mechanistic role of γδ T cells in the pathogenesis of experimental psoriatic arthritis (PsA).In this study, we performed interleukin-23 (IL-23) gene transfer in wild-type (WT) and T cell receptor δ-deficie
Autor:
Jonathan D. Schoenfeld, F. Stephen Hodi, Scott J. Rodig, Alexander Spektor, Srinika Ranasinghe, Jason L. Weirather, James Lindsay, Kathleen L. Pfaff, Mariano Severgnini, Alexander A. Merleev, Alina I. Marusina, Emanual Maverakis, Sacha Gnjatic, Seunghee Kim-Schulze, Adrian Mariño-Enríquez, Mansoor M. Ahmed, Helen X. Chen, Howard Streicher, May Cho, Harvey J. Mamon, Elad Sharon, James M. Cleary, Osama E. Rahma, Olatunji B. Alese, Salma K. Jabbour, Anteneh Tesfaye, Ryan D. Gentzler, Claire Manuszak, Katrina Z. Kao, Ryan C. Brennick, Emily M. Thrash, Ana Lako, Anita Giobbie-Hurder, Arta M. Monjazeb
Purpose:Prospective human data are lacking regarding safety, efficacy, and immunologic impacts of different radiation doses administered with combined PD-L1/CTLA-4 blockade.Patients and Methods:We performed a multicenter phase II study randomly assig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103e97861a6db4ad698277b2b002fe60
https://doi.org/10.1158/1078-0432.c.6531336
https://doi.org/10.1158/1078-0432.c.6531336
Autor:
Jonathan D. Schoenfeld, F. Stephen Hodi, Scott J. Rodig, Alexander Spektor, Srinika Ranasinghe, Jason L. Weirather, James Lindsay, Kathleen L. Pfaff, Mariano Severgnini, Alexander A. Merleev, Alina I. Marusina, Emanual Maverakis, Sacha Gnjatic, Seunghee Kim-Schulze, Adrian Mariño-Enríquez, Mansoor M. Ahmed, Helen X. Chen, Howard Streicher, May Cho, Harvey J. Mamon, Elad Sharon, James M. Cleary, Osama E. Rahma, Olatunji B. Alese, Salma K. Jabbour, Anteneh Tesfaye, Ryan D. Gentzler, Claire Manuszak, Katrina Z. Kao, Ryan C. Brennick, Emily M. Thrash, Ana Lako, Anita Giobbie-Hurder, Arta M. Monjazeb
Supplementary Data and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ef39a1bd1b4d365aae5a1aa7a6475ad
https://doi.org/10.1158/1078-0432.22484139.v1
https://doi.org/10.1158/1078-0432.22484139.v1
Autor:
Alina I. Marusina, Antonio Ji-Xu, Stephanie T. Le, Atrin Toussi, Lam C. Tsoi, Qinyuan Li, Guillaume Luxardi, Jordan Nava, Lauren Downing, Annie R. Leal, Nikolay Y. Kuzminykh, Olga Kruglinskaya, Marie-Charlotte Brüggen, Iannis E. Adamopoulos, Alexander A. Merleev, Johann E. Gudjonsson, Emanual Maverakis
Publikováno v:
Journal of Investigative Dermatology.
Autor:
Maxwell A Fung, Alexander A. Merleev, Jordan Nava, Atrin Toussi, Alina I. Marusina, Annie Riera Leal, Jason Kao, Michelle Y. Cheng, William Liakos, Monica Tran, E. A. Wang, Stephanie T. Le, Guillaume Luxardi, Claire Alexanian, Emanual Michael Maverakis
Publikováno v:
Clinical and Experimental Dermatology. 46:910-914
Lupus miliaris disseminatus faciei (LMDF) is a chronic inflammatory dermatosis of unknown aetiology, most often seen in young adults. Although many treatments for LMDF exist, treatment guidelines have not been developed, and response to therapy is ge